Abstract：
:Glutamate has been implicated in signal transmission between inner hair cells and afferent fibers of the organ of Corti. The inner hair cells are enriched in glutamate and the postsynaptic membranes express AMPA glutamate receptors. However, it is not known whether inner hair cells contain a mechanism for glutamate replenishment. Such a mechanism must be in place to sustain glutamate neurotransmission. Here we provide RT-PCR and immunofluorescence data indicating that system A transporter 1 (SLC38A1), which is associated with neuronal glutamine transport and synthesis of the neurotransmitters GABA and glutamate in CNS, is expressed in inner hair cells. It was previously shown that inner hair cells contain glutaminase that converts glutamine to glutamate. Thus, our finding that inner hair cells express a glutamine transporter and the key glutamine metabolizing enzyme glutaminase, provides a mechanism for glutamate replenishment and bolsters the idea that glutamate serves as a transmitter in the peripheral synapse of the auditory system.
journal_name
Hear Resjournal_title
Hearing researchauthors
Oguchi T,Suzuki N,Hashimoto S,Chaudhry GA,Chaudhry FA,Usami S,Ottersen OPdoi
10.1016/j.heares.2012.07.005subject
Has Abstractpub_date
2012-10-01 00:00:00pages
59-63issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(12)00181-5journal_volume
292pub_type
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