Volume fraction and ultrastructure of age pigment in the saccular epithelium of old mice.

Abstract:

:Age pigment in the sensory and supporting cells was a prominent characteristic distinguishing old saccules from young. However, the pigment was not distributed uniformly throughout the sensory epithelium but displayed cell-specific patterns of accumulation. The highest cytoplasmic volume density was in the old supporting cells followed by type I hair cells and then type II hair cells. The most common form of pigmented inclusion seen in old type I hair cells was a cluster of granules resembling melanin. This form was never seen in type II hair cells or supporting cells where a form containing a lipid-like droplet was prevalent. The differences in the amount of age pigment and the forms accumulated probably reflects metabolic differences between the three cell types.

journal_name

Hear Res

journal_title

Hearing research

authors

Hubel SB,Park JC

doi

10.1016/0378-5955(89)90038-5

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

171-7

issue

2

eissn

0378-5955

issn

1878-5891

pii

0378-5955(89)90038-5

journal_volume

37

pub_type

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