The cell potential of isolated inner hair cells in vitro.

abstract：:A common problem among the elderly is a difficulty in discriminating speech sounds. One factor that may contribute to this is a deterioration in the ability to process dynamic aspects of speech such as formant transitions. For the aging auditory system, this deterioration in temporal processing speed may be manifest a...

journal_title：Hearing research

authors： Mendelson JR,Ricketts C

更新日期：2001-08-01 00:00:00

abstract：:1. The sound pressure level required to produce a detectable gross action potential (N1) in the guinea pig was measured for a range of frequencies. The resulting electrocochleogram was compared with the click level require to produce a detectable N1. 2. Over most of the auditory range (1-30 kHz) the required click lev...

journal_title：Hearing research

authors： Johnstone JR

更新日期：1981-07-01 00:00:00

abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...

journal_title：Hearing research

authors： Shi GZ,Gong LX,Xu XH,Nie WY,Lin Q,Qi YS

更新日期：2004-11-01 00:00:00

abstract：:The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...

journal_title：Hearing research

authors： Rutkowski RG,Miasnikov AA,Weinberger NM

更新日期：2003-07-01 00:00:00

abstract：:Noise, hearing loss, and electronic signal distortion, which are common problems in military environments, can impair speech intelligibility and thereby jeopardize mission success. The current study investigated the impact that impaired communication has on operational performance in a command and control environment ...

journal_title：Hearing research

authors： Keller MD,Ziriax JM,Barns W,Sheffield B,Brungart D,Thomas T,Jaeger B,Yankaskas K

更新日期：2017-06-01 00:00:00

abstract：:Most previous reports of ototoxicity following exposure to several volatile organic solvents have restricted testing to the low- and mid-frequencies (2-20 kHz) of the hearing range in the rat (0.25-80 kHz). We report here that inhalation exposure to styrene, mixed xylene, toluene, and 1,1,2-trichloroethylene resulted ...

journal_title：Hearing research

authors： Crofton KM,Lassiter TL,Rebert CS

更新日期：1994-10-01 00:00:00

abstract：:Single-unit recordings from neurons in the torus semicircularis of Rana ridibunda were analyzed to determine the degree to which these neurons can detect acoustic stimuli superimposed on continuous, broad-band noise. In the first series of trials the stimuli were tone pulses 25 ms long, 5 dB above threshold, and at th...

journal_title：Hearing research

authors： Joermann G

更新日期：1988-09-15 00:00:00

abstract：:Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants ...

journal_title：Hearing research

authors： Jiam NT,Caldwell M,Deroche ML,Chatterjee M,Limb CJ

更新日期：2017-09-01 00:00:00

abstract：UNLABELLED:While the positive benefits of pediatric cochlear implantation on language perception skills are now proven, the heterogeneity of outcomes remains high. The understanding of this heterogeneity and possible strategies to minimize it is of utmost importance. Our scope here is to test the effects of an auditory...

journal_title：Hearing research

authors： Roman S,Rochette F,Triglia JM,Schön D,Bigand E

更新日期：2016-07-01 00:00:00

abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...

journal_title：Hearing research

authors： Gross J,Rheinländer C,Fuchs J,Mazurek B,Machulik A,Andreeva N,Kietzmann T

更新日期：2003-09-01 00:00:00

abstract：:The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...

journal_title：Hearing research

authors： Nenov AP,Norris C,Bobbin RP

更新日期：1996-11-01 00:00:00

abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

journal_title：Hearing research

authors： Ruan RS,Leong SK,Yeoh KH

更新日期：1997-12-01 00:00:00

abstract：:The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

journal_title：Hearing research

authors： Gleich O,Langemann U

更新日期：2011-03-01 00:00:00

abstract：:Electrical stimulation of the cochlea with a multiple-electrode array is best accomplished using pulsatile instead of continuous stimulation. The optimum shapes of electrical pulses for this purpose are still uncertain due to a lack of knowledge about their stimulation efficiency and requirements of the encoding strat...

journal_title：Hearing research

authors： Wiler JA,Clopton BM,Mikhail MA

更新日期：1989-06-01 00:00:00

abstract：:The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial...

journal_title：Hearing research

authors： Marco RA,Hoffman LF,Wackym PA,Micevych PE,Popper P

更新日期：1996-08-01 00:00:00

abstract：:New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...

journal_title：Hearing research

authors： Kelley MW,Ochiai CK,Corwin JT

更新日期：1992-04-01 00:00:00

abstract：:Decrement detection is a commonly used psychophysical technique in which a subject is required to detect partially filled gaps in an ongoing sound. The paradigm provides information regarding both temporal resolution and intensity discrimination. The purpose of this project was to determine if an evoked-potential para...

journal_title：Hearing research

authors： Boettcher FA,Emery M

更新日期：2006-02-01 00:00:00

abstract：:Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessi...

journal_title：Hearing research

authors： Claußen M,Schulze J,Nothwang HG

更新日期：2020-06-01 00:00:00

abstract：:An analysis of the central projections of the ventral nucleus of the trapezoid body (VNTB) in the rat, a region of the superior olivary complex known for its neuronal heterogeneity, was made using two anterograde axonal tracers, [3H]leucine and biotinylated dextran amine (BDA). A mixture of these tracers was injected ...

journal_title：Hearing research

authors： Warr WB,Beck JE

更新日期：1996-04-01 00:00:00

abstract：:Action potentials recorded extracellularly from neurons within the caudal cochlear nuclei of developing cats exhibited distinctive temporal characteristics (i.e., rhythmic responses) in response to long-duration acoustic stimuli including both tone and noise bursts. Unlike the homogeneous response characteristics of a...

journal_title：Hearing research

authors： Walsh EJ,McGee J

更新日期：1988-11-01 00:00:00

abstract：:There are three main cues to sound location: the interaural differences in time (ITD) and level (ILD) as well as the monaural spectral shape cues. These cues are generated by the spatial- and frequency-dependent filtering of propagating sound waves by the head and external ears. Although the chinchilla has been used f...

journal_title：Hearing research

authors： Koka K,Jones HG,Thornton JL,Lupo JE,Tollin DJ

更新日期：2011-02-01 00:00:00

abstract：:Many natural sounds such as speech contain concurrent amplitude and frequency modulation (AM and FM), with the FM components often in the form of directional frequency sweeps or glides. Most studies of modulation coding, however, have employed one modulation type in stationary carriers, and in cases where mixed-modula...

journal_title：Hearing research

authors： Hsieh IH,Saberi K

更新日期：2010-04-01 00:00:00

abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...

journal_title：Hearing research

authors： Cacace AT

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To objectively measure speech intelligibility of individual subjects from the EEG, based on cortical tracking of different representations of speech: low-level acoustical, higher-level discrete, or a combination. To compare each model's prediction of the speech reception threshold (SRT) for each individual wi...

journal_title：Hearing research

authors： Lesenfants D,Vanthornhout J,Verschueren E,Decruy L,Francart T

更新日期：2019-09-01 00:00:00

abstract：:Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...

journal_title：Hearing research

authors： Sato K,Shiraishi S,Nakagawa H,Kuriyama H,Altschuler RA

更新日期：2000-09-01 00:00:00

abstract：:Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...

journal_title：Hearing research

authors： Dulon D,Zajic G,Schacht J

更新日期：1991-03-01 00:00:00

abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...

journal_title：Hearing research

authors： Tabuchi K,Ito Z,Tsuji S,Wada T,Takahashi K,Hara A,Kusakari J

更新日期：2000-06-01 00:00:00

abstract：:The effects of glycerol, urea and mannitol on the structure of the murine endolymphatic sac were investigated at various time intervals after their administration. Within 15 min after administration of glycerol and urea the lumen of the endolymphatic sac was partially collapsed and the density of its contents was incr...

journal_title：Hearing research

authors： Erwall C

更新日期：1988-11-01 00:00:00

abstract：:Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. W...

journal_title：Hearing research

authors： Jiang H,Wang X,Zhang J,Kachelmeier A,Lopez IA,Shi X

更新日期：2019-01-01 00:00:00

abstract：:Most investigators place reflective beads on the basilar membrane to measure its vibration with optical methods. It is therefore important to find out if the beads faithfully follow the motion of the structures on which they are placed. Vibration of the beads on the basilar membrane and basilar membrane adjacent to th...

journal_title：Hearing research

authors： Khanna SM,Ulfendahl M,Steele CR

更新日期：1998-02-01 00:00:00