Abstract:
:Electrical stimulation of the cochlea with a multiple-electrode array is best accomplished using pulsatile instead of continuous stimulation. The optimum shapes of electrical pulses for this purpose are still uncertain due to a lack of knowledge about their stimulation efficiency and requirements of the encoding strategy. We presented an extensive set of charge-balanced, rectangular pulse shapes to the guinea pig cochlea. Durations per phase for these constant-current pulses ranged from 20 microseconds to 900 microseconds with initially positive and initially negative polarities. Spike counts from single units in the anteroventral cochlear nucleus differed significantly for different pulse shapes, as did their initial latencies. Implications for stimulation efficiency and encoding strategies are discussed.
journal_name
Hear Resjournal_title
Hearing researchauthors
Wiler JA,Clopton BM,Mikhail MAdoi
10.1016/0378-5955(89)90045-2subject
Has Abstractpub_date
1989-06-01 00:00:00pages
251-61issue
3eissn
0378-5955issn
1878-5891pii
0378-5955(89)90045-2journal_volume
39pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::The saccule and the utricle of the vestibular system detect linear acceleration and gravity. Sensory transduction in these organs depends on myriads of calcium carbonate crystals of high specific gravity, called otoconia, embedded in a filament matrix that overlies the sensory epithelium. The coexistence of hard cryst...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00007-6
更新日期:1999-05-01 00:00:00
abstract::The distribution of actin, alpha-actinin, fimbrin, tropomyosin and tubulin in the apical region of inner and outer hair cells was studied by immunofluorescent localization of antibodies to these proteins. The macromolecular distribution of actin and alpha-actinin was studied using post-embedding immunoelectron microsc...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90029-2
更新日期:1985-01-01 00:00:00
abstract::In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90127-9
更新日期:1992-03-01 00:00:00
abstract::This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00365-3
更新日期:2001-12-01 00:00:00
abstract::There is convincing evidence that cochlear microphonics (CM) arise primarily from outer hair cells and have a frequency distribution that is much broader than that measured in inner hair cells by Russel and Sellick [6,7]. The broad tuning results from the fact that CM generated at each location decays exponentially al...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(80)90092-1
更新日期:1980-06-01 00:00:00
abstract::We recorded auditory evoked magnetic fields from 8 patients with unilateral, idiopathic, sudden, sensorineural hearing loss and from 8 healthy controls, using a 122-channel whole-scalp neuromagnetometer. The stimuli were 50-ms l-kHz tone bursts, delivered to the healthy ear at interstimulus intervals (ISIs) of 1, 2, 4...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00086-j
更新日期:1995-07-01 00:00:00
abstract::Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00047-2
更新日期:2000-06-01 00:00:00
abstract::Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.09.007
更新日期:2007-05-01 00:00:00
abstract::An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.02.011
更新日期:2006-05-01 00:00:00
abstract::The human auditory system is comprised of specialized but interacting anatomic and functional pathways encoding object, spatial, and temporal information. We review how learning-induced plasticity manifests along these pathways and to what extent there are common mechanisms subserving such plasticity. A first series o...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2010.03.086
更新日期:2011-01-01 00:00:00
abstract::The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00133-6
更新日期:1998-10-01 00:00:00
abstract::Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction i...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.10.006
更新日期:2010-01-01 00:00:00
abstract::Severe damage to the organ of Corti leads to degeneration of the spiral ganglion cells (SGCs) which form the auditory nerve. This degeneration starts at the level of synaptic connection of the peripheral processes (PPs) of SGCs with the cochlear hair cells. It is generally thought that from this point SGC degeneration...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.107928
更新日期:2020-05-01 00:00:00
abstract::Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00339-8
更新日期:2002-07-01 00:00:00
abstract::Speech is central to human life. As such, any delay or impairment in receptive speech processing can have a profoundly negative impact on the social and professional life of a person. Thus, being able to assess the integrity of speech processing in different populations is an important goal. Current standardized asses...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2017.02.015
更新日期:2017-05-01 00:00:00
abstract::We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00694-9
更新日期:2002-12-01 00:00:00
abstract::The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00182-5
更新日期:2003-07-01 00:00:00
abstract::Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00137-8
更新日期:1997-11-01 00:00:00
abstract::Normal-hearing listeners can perceptually segregate concurrent sound sources, but listeners with significant hearing loss or who wear a cochlear implant (CI) lag behind in this ability. Perceptual grouping mechanisms are essential to segregate concurrent sound sources and affect comodulation masking release (CMR). Thu...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.11.023
更新日期:2013-02-01 00:00:00
abstract::Nitric oxide (NO) hyperpolarizes vascular smooth muscle cells and dilates blood vessels of various beds, but little is known on cochlear vasculatures. Using in vitro preparations of the spiral modiolar artery (SMA), intracellular electrical recording and labeling techniques, we found that the NO donor DPTA-NONOate (10...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00497-5
更新日期:2002-09-01 00:00:00
abstract::During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. I...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00078-2
更新日期:2000-07-01 00:00:00
abstract::The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)00159-n
更新日期:1995-01-01 00:00:00
abstract::Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system and enhanced recovery in animal models of neurodegenerative diseases. In addition, FKBP-12 is t...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00319-7
更新日期:2001-09-01 00:00:00
abstract::Carbohydrate distribution in the fresh utricular macula of the guinea pig was analysed using lectins such as Concanavalin A (ConA), Dolichos biflorus agglutinin (DBA), peanut agglutinin (PNA), soybean agglutinin (SBA), Ulex europeus agglutinin (UEA-1) and wheat germ agglutinin (WGA) by means of confocal laser scanning...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00075-f
更新日期:1995-07-01 00:00:00
abstract::Gaumond et al. [(1982) J. Neurophysiol. 48, 856-873] showed in the cat that a multiplicative-intensity model can generally account quite well for reduction of the probability of an auditory-nerve spike by another spike preceding it by 4 to 25 ms, and that for smaller separations there is also an increased latency of t...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90093-g
更新日期:1993-09-01 00:00:00
abstract::One can construct narrow bands of noise that contain delays of either the envelope, the phase, or the carrier separately or in combination. Delayed and undelayed noises will have identical spectra if, and only if, both the envelope and the phase undergo delays of the same magnitude. To study lateralization of these si...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90163-8
更新日期:1987-01-01 00:00:00
abstract::We have analyzed a model for the motion of hair bundles of hair cells at high frequencies. In the model, hair-cell organs are represented as a system of rigid mechanical structures surrounded by fluid. A rigid body, that represents a hair bundle, is hinged to a vibrating plate that represents the sensory epithelium. T...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90197-w
更新日期:1990-09-01 00:00:00
abstract::A simplified network model of the organ of Corti is analyzed with the assumption of parametric excitation via resistance changes in the hair cells' apical membrane. Pertinent network variables (intracellular resting and receptor potentials, cellular input resistance, extracellular potentials) depend on the ratios of b...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90120-x
更新日期:1983-10-01 00:00:00
abstract::We are studying the interconnections between the anteroventral cochlear nucleus (AVCN) and the dorsal cochlear nucleus (DCN). Biotinylated dextran was injected into the DCN, where the best frequency of responses was also recorded. Ventrotubercular neurons in AVCN were labeled, along with cochlear nerve fibers and the ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00224-x
更新日期:1999-04-01 00:00:00
abstract::The focus of this study was to gauge the influence of intervening interference on an intensity standard held within auditory working memory through measurement of the just noticeable difference (JND) for intensity. Additionally, the use of interaural phase differences and interaural level differences as spatial cues w...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.04.004
更新日期:2008-06-01 00:00:00