Abstract：
:Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system and enhanced recovery in animal models of neurodegenerative diseases. In addition, FKBP-12 is tightly bound to the calcium release channel ryanodine receptor and physiologically interacts with the inositol 1,4,5-trisphosphate receptor. In nearly all cell types, release of intracellular Ca(2+) and subsequent second messenger signaling involves activation of these ion channels. We determined the distribution of FKBP-12 within the mammalian cochlea and dorsal cochlear nucleus (DCN) in order to gain insight into Ca(2+) regulation within the cochlea and to possibly identify potential cellular targets for neuroimmunophilin ligands that may prove useful in protection and recovery following ototoxic insult. FKBP-12 protein and mRNA were found to be abundant throughout rat and guinea pig cochlea and DCN.
journal_name
Hear Resjournal_title
Hearing researchauthors
Zajic G,Henley C,Louis JC,Nicolson M,Magal Edoi
10.1016/s0378-5955(01)00319-7keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
125-31issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595501003197journal_volume
159pub_type
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