Abstract：
:The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or lamellar material, or both, in the light epithelial cells. Similar material was also present in the lumen of the endolymphatic sac, suggesting a common source and increased secretory activity. Mannitol caused similar changes, though less pronounced. The possibility that the alterations in the fine structure of the endolymphatic sac may be associated with a reduction in the hydrostatic fluid pressure in the rest of the labyrinth is discussed.
journal_name
Hear Resjournal_title
Hearing researchauthors
Erwall C,Jansson B,Friberg U,Rask-Andersen Hdoi
10.1016/0378-5955(88)90045-7subject
Has Abstractpub_date
1988-09-01 00:00:00pages
109-18issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(88)90045-7journal_volume
35pub_type
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