当前位置： SCI文献检索 > HEARING RESEARCH期刊下所有文献 > Plastic changes along auditory pathway during salicylate-induced ototoxicity: Hyperactivity and CF shifts.

Plastic changes along auditory pathway during salicylate-induced ototoxicity: Hyperactivity and CF shifts.

Abstract：

:High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, the diminished neural output of the cochlea is accompanied by a dramatic increase in sound-evoked activity in the auditory cortex (AC) and several other parts of the central nervous system. Exactly where the increase in neural activity begins and builds up along the central auditory pathway are not fully understood. To address this issue, we measured sound-evoked neural activity in the cochlea, cochlear nucleus (CN), inferior colliculus (IC), and AC before and after administering a high dose of sodium salicylate (SS, 300 mg/kg). The SS-treatment abolished low-level sound-evoked responses along the auditory pathway resulting in a 20-30 dB threshold shift. While the neural output of the cochlea was substantially reduced at high intensities, the neural responses in the CN were only slightly reduced; those in the IC were nearly normal or slightly enhanced while those in the AC considerably enhanced, indicative of a progress increase in central gain. The SS-induced increase in central response in the IC and AC was frequency-dependent with the greatest increase occurring in the mid-frequency range the putative pitch of SS-induced tinnitus. This frequency-dependent hyperactivity appeared to result from shifts in the frequency receptive fields (FRF) such that the response areas of many FRF shifted/expanded toward the mid-frequencies. Our results suggest that the SS-induced threshold shift originates in the cochlea. In contrast, enhanced central gain is not localized to one region, but progressively builds up at successively higher stage of the auditory pathway either through a loss of inhibition and/or increased excitation.

journal_name

Hear Res

journal_title

Hearing research

authors

Jiang C,Luo B,Manohar S,Chen GD,Salvi R

doi

10.1016/j.heares.2016.10.021

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

28-40

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(16)30220-9

journal_volume

347

pub_type

杂志文章

在线工具

Plastic changes along auditory pathway during salicylate-induced ototoxicity: Hyperactivity and CF shifts.