Abstract:
:Several studies have shown that treatment with various neurotrophins protects spiral ganglion cells (SGCs) from degeneration in hair-cell deprived cochleas. In most of these studies the neurotrophins are delivered by means of intracochlear delivery methods. Recently, other application methods that might be more suited in cochlear implant patients have been developed. We have examined if round window membrane application of gelfoam infiltrated with a neurotrophin resulted in SGC survival in deafened guinea pigs. Two weeks after deafening, gelfoam cubes infiltrated with 6 μg of brain-derived neurotrophic factor (BDNF) were deposited onto the round window membrane of the right cochleas. Electric pulses were delivered through an electrode positioned within the round window niche to electrically evoke auditory brainstem responses (eABRs). Two or four weeks after deposition of the gelfoam all cochleas were histologically examined. We found that local BDNF treatment enhances the survival of SGCs in the basal cochlear turn after two and four weeks. The treatment had no effect on SGC size or shape. In animals treated with BDNF, eABR amplitudes were smaller than in normal-hearing control animals and similar to those in deafened controls. We conclude that BDNF delivered by means of local gelfoam application provides a protective effect, which is limited compared to intracochlear delivery methods.
journal_name
Hear Resjournal_title
Hearing researchauthors
Havenith S,Versnel H,Agterberg MJ,de Groot JC,Sedee RJ,Grolman W,Klis SFdoi
10.1016/j.heares.2010.10.003subject
Has Abstractpub_date
2011-02-01 00:00:00pages
168-77issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(10)00393-Xjournal_volume
272pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Previous claims that auditory stream segregation occurs in cochlear implant listeners are based on limited evidence. In experiment 1, eight listeners heard tones presented in a 30-s repeating ABA-sequence, with frequencies matching the centre frequencies of the implant's 22 electrodes. Tone A always stimulated electro...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.11.010
更新日期:2007-03-01 00:00:00
abstract::We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00040-6
更新日期:2003-04-01 00:00:00
abstract::This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2011.05.001
更新日期:2011-11-01 00:00:00
abstract::Georg von Békésy was one of the first comparative auditory researchers. He not only studied basilar membrane (BM) movements in a range of mammals of widely different sizes, he also worked on the chicken basilar papilla and the frog middle ear. We show that, in mammals, at least, his data do not differ from those that ...
journal_title:Hearing research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.heares.2012.04.013
更新日期:2012-11-01 00:00:00
abstract::Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.06.004
更新日期:2019-09-15 00:00:00
abstract::Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the cellular distribution of this membrane transporter remains unknown. Here reverse transcription and the polymerase chain reaction (RT-PCR) were employed to screen adu...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00089-6
更新日期:1998-09-01 00:00:00
abstract::Hearing aids are a relatively non-invasive means of reducing the negative effects of hearing loss on an individual who does not require a cochlear implant. Music amplified through hearing aids has some interesting characteristics but high fidelity is not typically one of them. This poses a serious problem for the inve...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2013.07.003
更新日期:2014-02-01 00:00:00
abstract::Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.06.002
更新日期:2011-10-01 00:00:00
abstract::This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90012-c
更新日期:1992-02-01 00:00:00
abstract::The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization; (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2007.01.013
更新日期:2007-07-01 00:00:00
abstract::Spectral analysis of electrical noise recorded from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and changes in the spectral characteristics...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.02.006
更新日期:2004-06-01 00:00:00
abstract::Recent evidence suggests that the monkey's short-term memory in audition depends on a passively retained sensory trace as opposed to a trace reactivated from long-term memory for use in working memory. Reliance on a passive sensory trace could render memory particularly susceptible to confusion between sounds that are...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.01.011
更新日期:2013-04-01 00:00:00
abstract::Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00159-7
更新日期:1997-12-01 00:00:00
abstract::Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(86)90015-8
更新日期:1986-01-01 00:00:00
abstract::The peripheral auditory sense organ, the cochlea, receives innervation from lateral and medial olivocochlear neurons in the brainstem. These neurons are able to modulate cochlear neural output. Anatomical studies have shown that one of the neurotransmitters which is present in varicosities surrounding the olivocochlea...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.009
更新日期:2005-06-01 00:00:00
abstract::58 chicks or chick embryos were continuously exposed during 12 h on either embryonic day 18 or 20 or on post-hatching days 1, 10, 20 or 30 to 1.5 kHz pure tone at an intensity of 125 dB SPL. After a 20- or 30-day survival time, audiograms were recorded and then the basilar papillae were prepared for scanning electron ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90141-8
更新日期:1985-01-01 00:00:00
abstract::Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant use...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2010.06.015
更新日期:2010-10-01 00:00:00
abstract::We recorded auditory evoked magnetic fields from 8 patients with unilateral, idiopathic, sudden, sensorineural hearing loss and from 8 healthy controls, using a 122-channel whole-scalp neuromagnetometer. The stimuli were 50-ms l-kHz tone bursts, delivered to the healthy ear at interstimulus intervals (ISIs) of 1, 2, 4...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00086-j
更新日期:1995-07-01 00:00:00
abstract::To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00204-4
更新日期:1999-02-01 00:00:00
abstract::Making small head movements facilitates spatial hearing by resolving front-back confusions, otherwise common in free field sound source localization. The changes in interaural time difference (ITD) in response to head rotation provide a robust front-back cue, but whether interaural level difference (ILD) can be used a...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.03.020
更新日期:2019-06-01 00:00:00
abstract::The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specime...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.05.001
更新日期:2012-08-01 00:00:00
abstract::Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.11.010
更新日期:2012-01-01 00:00:00
abstract::In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00094-0
更新日期:2000-10-01 00:00:00
abstract::The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pul...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.01.010
更新日期:2012-03-01 00:00:00
abstract::Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00092-7
更新日期:2000-08-01 00:00:00
abstract::Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.107949
更新日期:2020-05-01 00:00:00
abstract::Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP wav...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2007.11.012
更新日期:2008-04-01 00:00:00
abstract::Males and females differ in their subcortical evoked responses to sound. For many evoked response measures, the sex difference is driven by a faster developmental decline of auditory processing in males. Using the frequency-following response (FFR), an evoked potential that reflects predominately midbrain processing o...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.108075
更新日期:2020-12-01 00:00:00
abstract::The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.12.025
更新日期:2016-10-01 00:00:00
abstract::Distortion-product emissions at 2f1-f2 were measured in developing, pigmented rats to determine the characteristics of the functional onset and maturation of these emitted responses. Distortion-product testing was conducted on postnatal days 12, 14, 18, 21, 24, 28, and 51. The geometric-mean frequencies of the primari...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90223-c
更新日期:1990-01-01 00:00:00