Abstract：
:In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensity, location patterns and time course of fluorescent labelling in each examined stage in the otolithic organs was studied. The presence and distribution of calbindin (CB)-D28K, one of the calcium-binding proteins constantly found in the mammalian and chicken cochlea and also in otolithic membrane of some adult mammals, was studied. Results in embryonal stages, postnatal and adult animals allow us to postulate that otoliths are mainly produced during the embryonal phase, but they may also be produced throughout the whole life span. Results also indicate that otoconia are dynamic structures which undergo turnover. The correspondence between the patterns of CB-D28K immunoreactivity and tetracycline fluorescence may indicate that CB-D28K participates in the formation of otoconia.
journal_name
Hear Resjournal_title
Hearing researchauthors
Balsamo G,Avallone B,Del Genio F,Trapani S,Marmo Fdoi
10.1016/s0378-5955(00)00094-0keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1-8issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(00)00094-0journal_volume
148pub_type
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