Abstract：
:The electrically evoked compound action potential (CAP) of the auditory nerve exhibits two peaks, termed N0, at 350 microseconds latency, and N1, at 550 microseconds latency. At low stimulus intensities the CAP consists solely of the long latency N1 peak. As the stimulus strength is increased the higher threshold N0 appears. At high stimulus intensities N1 disappears and only the N0 component of the CAP remains. It is postulated that N1 represents action potentials propagated from the dendritic processes of the auditory neurons and that N0 represents action potentials initiated on the axons of these cells. The N1 peak exhibits anomalous refractory behavior which can be identified in the electrically evoked auditory brainstem response (EABR). That behavior may be useful diagnostically in assessing the extent of dendrite degeneration in cochlear implant candidates and users.
journal_name
Hear Resjournal_title
Hearing researchauthors
Stypulkowski PH,van den Honert Cdoi
10.1016/0378-5955(84)90051-0subject
Has Abstractpub_date
1984-06-01 00:00:00pages
205-23issue
3eissn
0378-5955issn
1878-5891pii
0378-5955(84)90051-0journal_volume
14pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.01.013
更新日期：2009-03-01 00:00:00
abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90116-5
更新日期：1992-05-01 00:00:00
abstract：:Recent studies have shown that the vestibular and auditory systems of some species of birds have the capacity to generate sensory hair cells postnatally. We used a traditional technique, 3H-thymidine autoradiography, and a newer method, bromodeoxyuridine immunocytochemistry, to determine whether ongoing proliferation ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90149-h
更新日期：1992-01-01 00:00:00
abstract：:Localization of calmodulin, a calcium binding protein, was identified in adult gerbil cochleas using paraffin section immunohistochemistry and immunogold electron microscopy with monoclonal antibody against bovine calmodulin. Immunoreactive calmodulin was abundant in inner hair cells (IHCs), outer hair cells (OHCs) an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00220-3
更新日期：2001-01-01 00:00:00
abstract：:Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00063-5
更新日期：1999-07-01 00:00:00
abstract：:Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.017
更新日期：2017-05-01 00:00:00
abstract：:This article presents a comparison of Liouville-Green (LG) calculations and exact solutions of 2- and 3-dimensional cochlea models. The agreement is in general quite good. For certain choices of the model parameters, however, the 2- and 3-dimensional LG solutions show appreciable errors in the region just beyond the l...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90071-5
更新日期：1982-10-01 00:00:00
abstract：:Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell. The...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90052-o
更新日期：1992-06-01 00:00:00
abstract：:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00252-0
更新日期：2001-05-01 00:00:00
abstract：:Recently, many lines of evidence have supported the possibilities that vasopressin (VP) is closely linked to the formation of endolymphatic hydrops in Meniere's disease. In the present study, it was examined whether or not the chronic administration of VP might induce endolymphatic hydrops. For this purpose, histologi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00180-x
更新日期：2000-02-01 00:00:00
abstract：:Pairs of single units were recorded simultaneously from the same microelectrode in the medial geniculate body (MGB) of nitrous oxide anaesthetized cats. Crosscorrelation histograms of each spike train pairs were computed and distributed in five main classes, interpreted in terms of functional interaction between neigh...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90093-1
更新日期：1987-01-01 00:00:00
abstract：:We are studying the interconnections between the anteroventral cochlear nucleus (AVCN) and the dorsal cochlear nucleus (DCN). Biotinylated dextran was injected into the DCN, where the best frequency of responses was also recorded. Ventrotubercular neurons in AVCN were labeled, along with cochlear nerve fibers and the ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00224-x
更新日期：1999-04-01 00:00:00
abstract：:Electrically evoked compound action potentials (ECAPs) have been used to examine temporal response patterns of the auditory nerve in cochlear implant (CI) recipients. ECAP responses to individual pulses in a pulse train vary across stimulation rates for individual CI users. For very slow rates, auditory neurons have a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.06.004
更新日期：2017-08-01 00:00:00
abstract：:Primary afferent activity was recorded from the cochlear ganglion in chicken embryos (Gallus domesticus) at 19 days of incubation (E19). The ganglion was accessed via the recessus scala tympani and impaled with glass micropipettes. Frequency tuning curves were obtained using a computerized threshold tracking procedure...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)00172-m
更新日期：1995-02-01 00:00:00
abstract：:Peripheral auditory adaptation has been studied extensively in animal models, and multiple exponential components have been identified. This study explores the feasibility of estimating these component processes for human listeners with a peripheral model of adaptation. The processes were estimated from off-frequency ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00428-2
更新日期：2002-02-01 00:00:00
abstract：:The latency of the N1 component of tone burst evoked compound action potentials was examined in chinchilla following acute pure-tone trauma. At and below the trauma frequency (4 kHz) the N1 latency at threshold generally increased, while above the trauma frequency it decreased; tonotopically paralleling pitch shifts o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90047-3
更新日期：1983-07-01 00:00:00
abstract：:Listening to speech in noise can be effortful but when motivated people seem to be more persevering. Previous research showed effects of monetary reward on autonomic responses like cardiovascular reactivity and pupil dilation while participants processed auditory information. The current study examined the effects of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.07.011
更新日期：2018-09-01 00:00:00
abstract：:Middle-ear to basilar membrane (BM) velocity transfer functions are reported for seven locations in the hook region of a single cat cochlea. These transfer functions were recorded at high sound pressure levels in a linearized, or passive cochlea, and resemble those reported previously by Wilson and Evans (1983). They ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90084-z
更新日期：1992-11-01 00:00:00
abstract：:Biochemical and pharmacological evidence support a role for nitric oxide (NO) and glutathione (GSH) in the cochlea. GSH combines with NO in tissue to form nitrosoglutathione (GSNO) that can act as a storage form for GSH and NO. Therefore, we tested GSNO on sound-evoked responses of the cochlea (cochlear microphonic, C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00065-8
更新日期：1997-08-01 00:00:00
abstract：:The ultrastructure of the spiral ligament was compared in aged and young gerbils to assess the involvement of connective tissues in the lateral wall and particularly the fibrocytes in development of presbyacusis. Pathologic features in fibrocytes of senescent gerbils spanned a wide range reflecting different stages of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00581-6
更新日期：2002-10-01 00:00:00
abstract：:Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.06.002
更新日期：2011-10-01 00:00:00
abstract：:Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP wav...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.11.012
更新日期：2008-04-01 00:00:00
abstract：:Despite advances in technology, the ability to perceive music remains limited for many cochlear implant users. This paper reviews the technological, biological, and acoustical constraints that make music an especially challenging stimulus for cochlear implant users, while highlighting recent research efforts to overco...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2013.04.009
更新日期：2014-02-01 00:00:00
abstract：:Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90219-y
更新日期：1991-05-01 00:00:00
abstract：:Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00332-0
更新日期：2004-01-01 00:00:00
abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.09.010
更新日期：2019-01-01 00:00:00
abstract：:Males and females differ in their subcortical evoked responses to sound. For many evoked response measures, the sex difference is driven by a faster developmental decline of auditory processing in males. Using the frequency-following response (FFR), an evoked potential that reflects predominately midbrain processing o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108075
更新日期：2020-12-01 00:00:00
abstract：:We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.05.003
更新日期：2011-01-01 00:00:00
abstract：:Frequency and impulse responses were determined for isolated guinea pig outer hair cells by electrically stimulating the cells between two wire electrodes with white noise. Cells were attached to the bottom of a small culture dish at one end while the other end was freely moving. Results have the character of a damped...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(96)00082-2
更新日期：1996-09-01 00:00:00
abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00133-6
更新日期：1998-10-01 00:00:00
