Abstract:
:Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled alpha-bungarotoxin (alpha-bgtx), a close to irreversibly acting blocker of the nicotinic acetylcholine receptor (nAChR) of skeletal muscle and of electrocytes of Torpedo and Electrophorus. An irreversible and saturable binding (80 nM) of the radiolabelled compound to OHCs was observed. The number of alpha-bgtx sensitive binding sites present on each OHC was calculated to be about 2 X 10(-17) mol/OHC, which would amount to about 10(7) binding sites/cell. Preincubation with the reversibly acting cholinergic ligands, carbamylcholine (1 mM), nicotine (0.1 mM) and d-tubocurarine (1-100 microM) was found to inhibit alpha-bgtx binding to a varying degree. Atropine (0.05 mM), a muscarinic antagonist, had no influence on the binding of alpha-bgtx to OHCs. [3H]-QNB, a specific marker and antagonist for muscarinic AChR, and [125I]-kappa-toxin, known to react with neuronal and ganglionic nAChR, showed no specific binding to OHCs. The data indicate that a peripheral type nAChR is present on OHCs mediating ACh-induced modulation of the biomechanics of the cochlea by influencing OHC motility.
journal_name
Hear Resjournal_title
Hearing researchauthors
Plinkert PK,Zenner HP,Heilbronn Edoi
10.1016/0378-5955(91)90219-ysubject
Has Abstractpub_date
1991-05-01 00:00:00pages
123-30issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(91)90219-Yjournal_volume
53pub_type
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