Abstract:
:Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell. The effects of a variable-frequency suppressor on a constant-frequency probe, placed near characteristic frequency, were also investigated since this paradigm is commonly used in single unit experiments. Resulting magnitude changes were measured in the fundamental component of the ac receptor potential and/or in the total dc produced in the region of temporal overlap between the two stimulus inputs. This latter component is especially important when considering how changes in IHC responses relate to decreases in discharge rate in single auditory nerve fibers. Since the ac receptor potential is filtered by the hair cell's basolateral membrane, the dc component probably controls transmitter release at the characteristic frequency of these second-turn IHCs. Based on results from these and previous experiments, a proposal is advanced to explain the evolution of two-tone suppression in the peripheral auditory system. The paper also discusses the use of excitatory versus non-excitatory suppressors and includes a description of two-tone suppression areas at the mechanical, IHC and single unit levels. The explanation of low-side suppression areas is of special interest since hitherto they have been difficult to model (Kim, 1985).
journal_name
Hear Resjournal_title
Hearing researchauthors
Cheatham MA,Dallos Pdoi
10.1016/0378-5955(92)90052-okeywords:
subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1-12issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(92)90052-Ojournal_volume
60pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00191-6
更新日期:2003-08-01 00:00:00
abstract::Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00159-7
更新日期:1997-12-01 00:00:00
abstract::Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.03.007
更新日期:2009-07-01 00:00:00
abstract::Some important relationships between two auditory nonlinearities, unmasking and combination tone (CT) production, are described. An example of unmasking is provided by using a forward-masking paradigm where a baseline is first obtained by determining the threshold of a 2000 Hz signal preceded by a 2000 Hz masker. When...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(80)90070-2
更新日期:1980-06-01 00:00:00
abstract::Kanamycin ototoxicity, combined with behavioral audiometry to evaluate threshold shifts, was used to destroy outer hair cells (OHCs) in the basal cochlea of the chincilla while leaving the inner hair cell (IHC) population largely intact. After survival times of four weeks to one year, transmission electron microscopy ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(80)90027-1
更新日期:1980-12-01 00:00:00
abstract::We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90237-2
更新日期:1994-03-01 00:00:00
abstract::Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00047-2
更新日期:2000-06-01 00:00:00
abstract::The ultrastructure of the sensory epithelia in the auditory regions of the ear, the sacculus and lagena, were investigated in the blue gourami, Trichogaster trichopterus, using transmission and scanning electron microscopy. The sensory epithelium consists of sensory hair cells surrounded by supporting cells, both of w...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(81)90049-6
更新日期:1981-11-01 00:00:00
abstract::Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exp...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90128-5
更新日期:1985-01-01 00:00:00
abstract::Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.11.010
更新日期:2012-01-01 00:00:00
abstract::Auditory brainstem responses (ABR) to clicks and noise bursts of various frequency bands and intensities were recorded in two bottlenosed dolphins, Tursiops truncatus. The purpose was to assess contributions of various parts of the cochlear partition to ABR and travelling wave velocity in the cochlea. At band-pass fil...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00234-3
更新日期:2001-01-01 00:00:00
abstract::The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00182-5
更新日期:2003-07-01 00:00:00
abstract::Gamma-aminobutyric acid (GABA)-like immunoreactivity in the chick basilar papilla and lagenar macula was studied by using anti-serum against GABA coupled with glutaraldehyde to bovine serum albumin. GABA-like immunoreactivity was localized selectively in the cytoplasm of both tall and short hair cells in the basilar p...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90178-x
更新日期:1987-01-01 00:00:00
abstract::Although the neural mechanisms underlying pitch perception are not yet fully understood, there is general agreement that place and temporal representations of pitch are both used by the auditory system. This paper describes a neural network model of pitch perception that integrates both codes of pitch and explores the...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.11.005
更新日期:2017-02-01 00:00:00
abstract::A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00005-1
更新日期:1997-04-01 00:00:00
abstract::Older adults are often reported in the literature to have greater difficulty than younger adults understanding speech in noise [Helfer and Wilber (1988). J. Acoust. Soc. Am, 859-893]. The poorer performance of older adults has been attributed to a general deterioration of cognitive processing, deterioration of cochlea...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.09.001
更新日期:2014-11-01 00:00:00
abstract::Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2017.01.006
更新日期:2017-09-01 00:00:00
abstract::Light microscopy and immunohistochemical analyses of a freshly prepared human cochlea, removed at meningioma skull base surgery, were performed with particular emphasis on synaptophysin (SY) reactivity. Synaptophysin, a 38-kDa glycoprotein, is one of the most abundant integral membrane proteins of small presynaptic ve...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00228-4
更新日期:2003-11-01 00:00:00
abstract::Subjective tinnitus may be defined as the perceptual correlate of altered spontaneous neural activity occurring in the absence of an externally evoking auditory stimulus. Tinnitus can be caused or exacerbated by one or more of five forms of stress. We propose and provide evidence supporting a model that explains, but ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(00)00235-5
更新日期:2001-02-01 00:00:00
abstract::The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90138-4
更新日期:1994-09-01 00:00:00
abstract::Several lines of evidence implicate a neurotransmitter/modulator role for ATP in the cochlea. Most of the work supporting such a notion has been accomplished using in vitro preparations of sensory hair cells or other cochlear tissues. Little is known regarding the functional consequences of ATP receptor activation in ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90091-4
更新日期:1994-06-01 00:00:00
abstract::In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.11.006
更新日期:2006-02-01 00:00:00
abstract::The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00142-6
更新日期:1996-11-01 00:00:00
abstract::Test of amplitude modulation detection threshold against modulation frequency (Mf) is one of the major measures in behavior studies for exploring temporal acuity of the auditory system. In this experiment, we recorded cortical responses from implanted electrodes in guinea pigs to generate temporal modulation transfer ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.10.004
更新日期:2009-01-01 00:00:00
abstract::Cochlear implant (CI) users typically have excellent speech recognition in quiet but struggle with understanding speech in noise. It is thought that broad current spread from stimulating electrodes causes adjacent electrodes to activate overlapping populations of neurons which results in interactions across adjacent c...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.02.004
更新日期:2013-05-01 00:00:00
abstract::A mathematical model of the evolution of statoconia in statocysts of freshwater snails based on the analysis of experimental data [Wiederhold et al., 1990; Pedrozo et al., 1996; Gao et al., 1997; Gao and Wiederhold, 1997; Wiederhold et al., 1999] is proposed. The growth of statoconia is considered as the process of so...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00185-4
更新日期:2001-04-01 00:00:00
abstract::Spike potentials were recorded from single, afferent fibres in the pigeon auditory nerve. Pure-tone stimuli were presented in quiet and in combination with wide band noise. Presented alone, tones produced tuned response areas; noise generally drove spike rate to well above the spontaneous rate measured in quiet. When ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90081-6
更新日期:1989-05-01 00:00:00
abstract::Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.05.013
更新日期:2005-11-01 00:00:00
abstract::There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on T...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.10.010
更新日期:2006-02-01 00:00:00
abstract::Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90023-x
更新日期:1994-08-01 00:00:00