Simultaneous suppression of tone burst-evoked otoacoustic emissions--effect of level and presentation paradigm.


:There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on TEOAE suppression are consistent with generation within largely independent channels, but with a degree of interaction between nearby channels. However, both these studies reported significant suppression only at high stimulus levels, at which the "nonlinear" presentation paradigm was used. The present study clarifies the separate influences of stimulus level and presentation paradigm on this type of suppression. TEOAEs were recorded using stimulus tone bursts at 1, 2 and 3 kHz and a complex stimulus consisting of a digital addition of the three tone bursts, over a range of stimulus levels and both "linear" and "nonlinear" presentation paradigms. Responses to the individual tone bursts were combined offline and compared with responses to the complex stimuli. Results clearly demonstrate that TEOAE suppression under these conditions is dependent upon stimulus level, and not upon presentation paradigm. It is further argued that the data support the "local" rather than "widespread" model of TEOAE generation, subject to nonlinear interactions between nearby generation channels.


Hear Res


Hearing research


Killan EC,Kapadia S





Has Abstract


2006-02-01 00:00:00














  • Mapping quantitative trait loci for hearing loss in Black Swiss mice.

    abstract::In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Drayton M,Noben-Trauth K

    更新日期:2006-02-01 00:00:00

  • Preferential and non-preferential transmission of formant information by an analogue cochlear implant using noise: the role of the nerve threshold.

    abstract::Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Morse RP,Evans EF

    更新日期:1999-07-01 00:00:00

  • Transverse and lateral mobility in outer hair cell lateral wall membranes.

    abstract::Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Oghalai JS,Tran TD,Raphael RM,Nakagawa T,Brownell WE

    更新日期:1999-09-01 00:00:00

  • Measurement of frequency selectivity of single neurons in the central auditory pathway.

    abstract::A large sample of threshold tuning curves of single units from various levels of the auditory pathway was used in order to examine the relationship between best frequency and a measure of sharpness of tuning. This measure is simply the tuning curve bandwidth at 20 dB above threshold on a square-root scale of frequency...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Calford MB,Webster WR,Semple MM

    更新日期:1983-09-01 00:00:00

  • Compression estimates using behavioral and otoacoustic emission measures.

    abstract::Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers -- one equal in frequency to the signal and another an octave below the signal. The ratio of the...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Williams EJ,Bacon SP

    更新日期:2005-03-01 00:00:00

  • Whole scalp resting state EEG of oscillatory brain activity shows no parametric relationship with psychoacoustic and psychosocial assessment of tinnitus: A repeated measures study.

    abstract::Tinnitus is a perception of sound that can occur in the absence of an external stimulus. A brief review of electroencephalography (EEG) and magnetoencephalography (MEG) literature demonstrates that there is no clear relationship between tinnitus presence and frequency band power in whole scalp or source oscillatory ac...

    journal_title:Hearing research

    pub_type: 杂志文章,随机对照试验


    authors: Pierzycki RH,McNamara AJ,Hoare DJ,Hall DA

    更新日期:2016-01-01 00:00:00

  • Localization and interaural time difference (ITD) thresholds for cochlear implant recipients with preserved acoustic hearing in the implanted ear.

    abstract::The purpose of this study was to investigate horizontal plane localization and interaural time difference (ITD) thresholds for 14 adult cochlear implant recipients with hearing preservation in the implanted ear. Localization to broadband noise was assessed in an anechoic chamber with a 33-loudspeaker array extending f...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gifford RH,Grantham DW,Sheffield SW,Davis TJ,Dwyer R,Dorman MF

    更新日期:2014-06-01 00:00:00

  • Rethinking sound detection by fishes.

    abstract::In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Popper AN,Fay RR

    更新日期:2011-03-01 00:00:00

  • Stiffness of sensory-cell hair bundles in the isolated guinea pig cochlea.

    abstract::Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Strelioff D,Flock A

    更新日期:1984-07-01 00:00:00

  • A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV).

    abstract::Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

    更新日期:2004-01-01 00:00:00

  • Circadian and menstrual rhythms in frequency variations of spontaneous otoacoustic emissions from human ears.

    abstract::This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bell A

    更新日期:1992-02-01 00:00:00

  • Auditory capabilities of birds in relation to the structural diversity of the basilar papilla.

    abstract::The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gleich O,Langemann U

    更新日期:2011-03-01 00:00:00

  • A nicotinic acetylcholine receptor-like alpha-bungarotoxin-binding site on outer hair cells.

    abstract::Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Plinkert PK,Zenner HP,Heilbronn E

    更新日期:1991-05-01 00:00:00

  • Superposition models of the discharge patterns of units in the lower auditory system.

    abstract::Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Linebarger DA,Johnson DH

    更新日期:1986-01-01 00:00:00

  • Infrared neural stimulation: beam path in the guinea pig cochlea.

    abstract::It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Moreno LE,Rajguru SM,Matic AI,Yerram N,Robinson AM,Hwang M,Stock S,Richter CP

    更新日期:2011-12-01 00:00:00

  • Cochlear microphonics and otoacoustic emissions in chronically de-efferented chinchilla.

    abstract::The effects of eliminating the olivocochlear bundle (OCB) on cochlear electromechanical properties were examined by measuring cochlear microphonics (CM) and distortion product otoacoustic emissions (DPOAEs) in chronically de-efferented chinchillas. The OCB fibers to the right ears were successfully sectioned in six ou...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Zheng XY,McFadden SL,Henderson D,Ding DL,Burkard R

    更新日期:2000-05-01 00:00:00

  • Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.

    abstract::Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ETARs) in glomerular pathogenesis. Here w...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Meehan DT,Delimont D,Dufek B,Zallocchi M,Phillips G,Gratton MA,Cosgrove D

    更新日期:2016-11-01 00:00:00

  • Peripheral auditory adaptation and fatigue: a model oriented review.

    abstract::A model is introduced for auditory adaptation based on the stochastic models that are widely documented for birth and death processes and used as a vehicle to review single unit and compound action potential studies as well as various models for adaptation and forward masking. It appears that such a model inherently i...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Eggermont JJ

    更新日期:1985-04-01 00:00:00

  • Round window stimulation with the floating mass transducer at constant pretension.

    abstract:OBJECTIVE:Mechanical stimulation of the round window (RW) of the cochlea is successfully done with the Vibrant Soundbridge (Med-El), but clinical outcomes show a substantial degree of variability. One source of variability is variation in the static force applied by the stimulator to the round window (Maier et al., 201...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Salcher R,Schwab B,Lenarz T,Maier H

    更新日期:2014-08-01 00:00:00

  • Forward and reverse transduction at the limit of sensitivity studied by correlating electrical and mechanical fluctuations in frog saccular hair cells.

    abstract::The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Denk W,Webb WW

    更新日期:1992-06-01 00:00:00

  • Subcellular changes in the endolymphatic sac after administration of hyperosmolar substances.

    abstract::The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Erwall C,Jansson B,Friberg U,Rask-Andersen H

    更新日期:1988-09-01 00:00:00

  • Identification of mRNA transcripts and immunohistochemical localization of Na/H exchanger isoforms in gerbil inner ear.

    abstract::Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the cellular distribution of this membrane transporter remains unknown. Here reverse transcription and the polymerase chain reaction (RT-PCR) were employed to screen adu...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bond BR,Ng LL,Schulte BA

    更新日期:1998-09-01 00:00:00

  • Detection efficiency of auditory steady state evoked by modulated noise.

    abstract:AIM:This study aimed to investigate the efficiency of Magnitude Squared Coherence (MSC) and Spectral F test (SFT) for the detection of auditory steady state responses (ASSR) obtained by amplitude-modulated noises. MATERIAL AND METHODS:Twenty individuals (12 women) without any history of neurological or audiological di...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Santos TS,Silva JJ,Lins OG,Melges DB,Tierra-Criollo CJ

    更新日期:2016-09-01 00:00:00

  • Suppressibility of the 2f1-f2 stimulated acoustic emissions in gerbil and man.

    abstract::The suppression tuning properties of the oto-acoustic distortion product emission, 2f1-f2 have been measured in the ear canal of gerbil and man. The results show the acoustic response to be suppressible in a similar, frequency-dependent manner in both species. Frequencies near to those of the stimulating tones are mos...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Brown AM,Kemp DT

    更新日期:1984-01-01 00:00:00

  • The relationship between auditory brainstem response and behavioral thresholds in normal hearing infants and adults.

    abstract::The nature of age-related improvements in auditory sensitivity was explored by comparing behavioral and auditory brainstem response (ABR) thresholds in 3- and 6-month-old infants and in adults. Thresholds were estimated for tone pips at 1, 4, and 8 kHz, presented at a rate of 13.3/s. The time course of development of ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Werner LA,Folsom RC,Mancl LR

    更新日期:1993-06-01 00:00:00

  • Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis.

    abstract::Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Takeuchi S,Ando M,Sato T,Kakigi A

    更新日期:2001-05-01 00:00:00

  • Speech reception with different bilateral directional processing schemes: Influence of binaural hearing, audiometric asymmetry, and acoustic scenario.

    abstract::Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds f...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Neher T,Wagener KC,Latzel M

    更新日期:2017-09-01 00:00:00

  • Auditory evoked potentials in aged gerbils: responses elicited by noises separated by a silent gap.

    abstract::The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Boettcher FA,Mills JH,Swerdloff JL,Holley BL

    更新日期:1996-12-01 00:00:00

  • Death pathways in noise-damaged outer hair cells.

    abstract::Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bohne BA,Harding GW,Lee SC

    更新日期:2007-01-01 00:00:00

  • Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.

    abstract::Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiolog...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Clinard CG,Tremblay KL,Krishnan AR

    更新日期:2010-06-01 00:00:00