Abstract：
:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effects of SS on current-evoked firing of pyramidal neurons and fast-spiking interneurons in layer II/III of auditory cortex slices in young rats (P12-P19). The two neuronal types were identified according to their characteristic patterns of current-evoked firing as recorded with whole-cell patch-clamp techniques and by their morphological features. Following perfusion of the brain slice with 1.4mM SS, the threshold current needed to evoke an action potential remained unchanged for pyramidal neurons (68.96+/-10.68 pA vs 70.39+/-12.14 pA, n=7, P>0.05), but significantly increased for fast-spiking interneurons (56.9+/-13.69 pA vs 74.04+/-15.73 pA, n=7, P<0.05). The drug perfusion caused no significant change in current-evoked firing rates in pyramidal neurons (-2.43+/-7.07%, n=14, P>0.05); however, it drastically and reversibly depressed those in fast-spiking interneurons by up to -49.88+/-10.39% (n=14, P<0.05). Our results suggest that functionally impairing fast-spiking interneurons, which are GABAergic and inhibitory, is probably one of the pathways through which SS raises excitability in the central auditory system and consequently produces tinnitus.
journal_name
Hear Resjournal_title
Hearing researchauthors
Su YY,Luo B,Wang HT,Chen Ldoi
10.1016/j.heares.2009.03.007subject
Has Abstractpub_date
2009-07-01 00:00:00pages
60-6issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(09)00063-Xjournal_volume
253pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.002
更新日期：2009-11-01 00:00:00
abstract：:The Frequency-Following Response (FFR) is a neurophonic auditory evoked potential that reflects the efficient encoding of speech sounds and is disrupted in a range of speech and language disorders. This raises the possibility to use it as a potential biomarker for literacy impairment. However, reference values for com...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:Projections from the posterior thalamus and medial geniculate body were labeled retrogradely with wheat germ agglutinin conjugated to horseradish peroxidase injected into the rat, cat, and squirrel monkey inferior colliculus. Neurons were found ipsilaterally in the (1) medial division of the medial geniculate body, (2...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00489-6
更新日期：2002-06-01 00:00:00
abstract：:An analysis of the central projections of the ventral nucleus of the trapezoid body (VNTB) in the rat, a region of the superior olivary complex known for its neuronal heterogeneity, was made using two anterograde axonal tracers, [3H]leucine and biotinylated dextran amine (BDA). A mixture of these tracers was injected ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00198-0
更新日期：1996-04-01 00:00:00
abstract：:The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00102-6
更新日期：1998-09-01 00:00:00
abstract：:To assess the effects of extracochlear electrical stimulation on cochlear structure, guinea pigs were implanted and stimulated with single middle ear electrodes either at round window or promontory sites, and their cochleae examined by transmission electron microscopy. Implanted but unstimulated, or unimplanted contro...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90214-0
更新日期：1987-11-01 00:00:00
abstract：:Sharp spatial selectivity is critical to auditory performance, particularly in pitch-related tasks. Most contemporary cochlear implants have employed monopolar stimulation that produces broad electric fields, which presumably contribute to poor pitch and pitch-related performance by implant users. Bipolar or tripolar ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.005
更新日期：2012-01-01 00:00:00
abstract：:Several studies have reported an increased incidence of auditory dysfunction among HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and caspases 3/7-activation studies to investigate the potential ototoxicity of fourteen HIV antiretroviral agents: Abacavir, AZT, Delavirdine, Didenosi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.01.005
更新日期：2014-04-01 00:00:00
abstract：:Otoconia are biomineral particles of microscopic size essential for perception of gravity and maintenance of balance. Millions of older Americans are affected in their mobility, quality of life and in their health by progressive demineralization of otoconia. Currently, no effective means to prevent or counteract this ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.05.019
更新日期：2010-09-01 00:00:00
abstract：:Transtympanic administration of gentamicin is a widely accepted and effective approach for treating patients with intractable vertigo. Previous studies have demonstrated the uptake, distribution and effects of gentamicin in peripheral vestibular and cochlear structures after transtympanic injection. However, little is...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.10.003
更新日期：2012-01-01 00:00:00
abstract：:The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90062-r
更新日期：1992-06-01 00:00:00
abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90127-9
更新日期：1992-03-01 00:00:00
abstract：:Immunocytochemical methods were used to examine cryosections of the embryonic and neonatal chicken cochlea in order to study the histological distribution of the Na+,K+-ATPase molecule during maturation. In complementary studies the Na+,K+-ATPase capacity of microdissected freeze-dried substructures of the cochlea was...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90212-7
更新日期：1987-11-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.021
更新日期：2017-04-01 00:00:00
abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.10.019
更新日期：2016-01-01 00:00:00
abstract：:This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90012-c
更新日期：1992-02-01 00:00:00
abstract：:The mastoid air cell system has traditionally been considered to have a passive role in gas exchange and pressure regulation of the middle ear possibly with some acoustic function. However, more evidence has focused on the mucosa of the mastoid, which may play a more active role in regulation of middle ear pressure. I...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.03.002
更新日期：2013-07-01 00:00:00
abstract：:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00005-1
更新日期：1997-04-01 00:00:00
abstract：:Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90219-y
更新日期：1991-05-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:In order to determine the place-frequency map of the rat cochlea, iontophoretic HRP-injections were made into the cochlear nucleus at electrophysiologically characterized positions. Distribution of retrograde HRP transport in cochlear spiral ganglion cells was analysed by means of a three dimensional reconstruction of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90041-7
更新日期：1991-02-01 00:00:00
abstract：:The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce auto-immune hearing loss. To determine if CTL2/SLC44A2 also has roles in inner ear development and to distinguish between isoform-specific roles, we assessed age-re...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.004
更新日期：2011-12-01 00:00:00
abstract：:Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.08.011
更新日期：2005-04-01 00:00:00
abstract：:Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90060-m
更新日期：1991-06-01 00:00:00
abstract：:Eighth nerve endings and neuronal types in the nucleus magnocellularis were analyzed in the red-eared turtle (Chrysemys scripta elegans). One group of turtles had horseradish peroxidase (HRP) injected into the surgically exposed inner ear. Following injection the animals survived for 3-5 days and then their 8th nerve ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90156-6
更新日期：1988-06-01 00:00:00
abstract：:The ability of auditory-nerve (AN) fibers to encode modulation frequencies, as characterized by temporal modulation transfer functions (TMTFs), generally shows a low-pass shape with a cut-off frequency that increases with fiber characteristic frequency (CF). Because AN-fiber bandwidth increases with CF, this result ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.02.004
更新日期：2012-04-01 00:00:00
abstract：:Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2020.107927
更新日期：2020-09-01 00:00:00
abstract：:In this study, which aims to investigate for the first time auditoty sensitivity in congenital central hypothyroidism (CH), we concluded that: (1) permanent sensorineural hearing loss may be observed not only in congenital primary disorders of thyroid function, as reported hitherto; (2) it may also be found in patient...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00515-4
更新日期：2002-10-01 00:00:00
abstract：:There is increasing evidence to suggest that free radical generation is central to a variety of pathological processes, including drug toxicity. Studies demonstrating the ability of gentamicin to facilitate the generation of radical species suggest that this process plays an important role in aminoglycoside-induced ot...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00171-8
更新日期：1998-01-01 00:00:00
