Oncomodulin is abundant in the organ of Corti.

Abstract:

:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in the parvalbumin family and possible identity with the mammalian beta-parvalbumin oncomodulin. As shown herein, the latter conclusion is supported by strong cross-reactivity between CBP-15 and isoform-specific antibodies to oncomodulin. Moreover, we have succeeded in amplifying the guinea pig CBP-15 coding sequence from organ of Corti cDNA using degenerate oligonucleotide primers based on the rat oncomodulin sequence. The deduced amino acid sequence of guinea pig CBP-15 displays 90%, 92%, and 98% identity with mouse, rat, and human oncomodulin isoforms. Demonstration of the presence of oncomodulin in the organ of Corti is the first documentation of this substance in a postnatal mammalian tissue.

journal_name

Hear Res

journal_title

Hearing research

authors

Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann R

doi

10.1016/s0378-5955(97)00005-1

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

105-11

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(97)00005-1

journal_volume

106

pub_type

杂志文章
  • The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.

    abstract::The endocochlear potential (EP) provides part of the electrochemical drive for sound-driven currents through cochlear hair cells. Intense noise exposure (110 dB SPL, 2 h) differentially affects the EP in three inbred mouse strains (C57BL/6 [B6], CBA/J [CBA], BALB/cJ [BALB]) (Ohlemiller and Gagnon, 2007, Hearing Resear...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.01.015

    authors: Ohlemiller KK,Kaur T,Warchol ME,Withnell RH

    更新日期:2018-04-01 00:00:00

  • High frequency transient-evoked otoacoustic emission measurements using chirp and click stimuli.

    abstract::Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.09.010

    authors: Keefe DH,Feeney MP,Hunter LL,Fitzpatrick DF,Blankenship CM,Garinis AC,Putterman DB,Wróblewski M

    更新日期:2019-01-01 00:00:00

  • Combination tones and unmasking.

    abstract::Some important relationships between two auditory nonlinearities, unmasking and combination tone (CT) production, are described. An example of unmasking is provided by using a forward-masking paradigm where a baseline is first obtained by determining the threshold of a 2000 Hz signal preceded by a 2000 Hz masker. When...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(80)90070-2

    authors: Tyler RS

    更新日期:1980-06-01 00:00:00

  • Neurotrophins and their role in the cochlea.

    abstract::Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in particular the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been described to be involved in the develo...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2012.03.002

    authors: Ramekers D,Versnel H,Grolman W,Klis SF

    更新日期:2012-06-01 00:00:00

  • The phase angle of addition in temporal masking for diotic and dichotic listening conditions.

    abstract::The phase angle, alpha, between a tonal signal and a tonal masker was varied from 0 degrees to 135 degrees in simultaneous masking, forward masking, and pulsation-threshold paradigms. In all conditions the frequency of the signal and masker was 500 Hz. For forward masking both diotic (MOSO) and dichotic (MOS pi) liste...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(82)90039-9

    authors: Yost WA,Grantham DW,Lutfi RA,Stern RM

    更新日期:1982-08-01 00:00:00

  • Potential role of angiotensin II in noise-induced increases in inner ear blood flow.

    abstract::Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90128-5

    authors: Wright JW,Dengerink HA,Miller JM,Goodwin PC

    更新日期:1985-01-01 00:00:00

  • Model calculations of steady state responses to binaural stimuli in the dorsal nucleus of the lateral lemniscus.

    abstract::Several studies have been performed in which both the time-dependent and steady state output of cells in the dorsal nucleus of the lateral lemniscus (DNLL) have been measured in response to binaural sound stimulation. In this paper, a mathematical and computational model for the steady state output of DNLL cells is fo...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00096-9

    authors: Reed MC,Blum JJ

    更新日期:1999-10-01 00:00:00

  • Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier.

    abstract::Several studies have shown that treatment with various neurotrophins protects spiral ganglion cells (SGCs) from degeneration in hair-cell deprived cochleas. In most of these studies the neurotrophins are delivered by means of intracochlear delivery methods. Recently, other application methods that might be more suited...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.10.003

    authors: Havenith S,Versnel H,Agterberg MJ,de Groot JC,Sedee RJ,Grolman W,Klis SF

    更新日期:2011-02-01 00:00:00

  • Improvement in sensorineural auditory threshold of the guinea-pig fetus following delivery.

    abstract::The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90289-5

    authors: Sohmer H,Goitein K,Freeman S

    更新日期:1994-02-01 00:00:00

  • Head shadow enhancement with low-frequency beamforming improves sound localization and speech perception for simulated bimodal listeners.

    abstract::Many hearing-impaired listeners struggle to localize sounds due to poor availability of binaural cues. Listeners with a cochlear implant and a contralateral hearing aid - so-called bimodal listeners - are amongst the worst performers, as both interaural time and level differences are poorly transmitted. We present a n...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.03.007

    authors: Dieudonné B,Francart T

    更新日期:2018-06-01 00:00:00

  • Plasticity of somatosensory inputs to the cochlear nucleus--implications for tinnitus.

    abstract::This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2011.05.001

    authors: Shore SE

    更新日期:2011-11-01 00:00:00

  • The order of testing effect in otoacoustic emissions and its consequences for sex and ear differences in neonates.

    abstract::The amplitude values of transient-evoked otoacoustic emissions, recorded from a large sample of neonates, were used to examine the asymmetry between ears tested and the differences due to the sex of the subject. Whilst the sex difference, with females having larger responses than males, has been a consistent finding i...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00234-x

    authors: Thornton AR,Marotta N,Kennedy CR

    更新日期:2003-10-01 00:00:00

  • Turtle utricle dynamic behavior using a combined anatomically accurate model and experimentally measured hair bundle stiffness.

    abstract::Anatomically correct turtle utricle geometry was incorporated into two finite element models. The geometrically accurate model included appropriately shaped macular surface and otoconial layer, compact gel and column filament (or shear) layer thicknesses and thickness distributions. The first model included a shear la...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2014.10.010

    authors: Davis JL,Grant JW

    更新日期:2014-12-01 00:00:00

  • The relative role of beats and combination tones in determining the shapes of masking patterns: II. Hearing-impaired listeners.

    abstract::Masking patterns were measured for hearing-impaired subjects with varying degrees of hearing loss. In one set of conditions, three subjects were tested using narrowband noise ('noise') and sinusoidal ('tone') maskers and narrowband noise signals. The maskers had centre frequencies of 0.25, 0.5, 1.0 and 4.0 kHz and lev...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00291-5

    authors: Alcántara JI,Moore BC

    更新日期:2002-03-01 00:00:00

  • An optimized, clinically relevant mouse model of cisplatin-induced ototoxicity.

    abstract::Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2019.02.006

    authors: Fernandez K,Wafa T,Fitzgerald TS,Cunningham LL

    更新日期:2019-04-01 00:00:00

  • The effect of presentation level on spectrotemporal modulation detection.

    abstract::The understanding of speech in noise relies (at least partially) on spectrotemporal modulation sensitivity. This sensitivity can be measured by spectral ripple tests, which can be administered at different presentation levels. However, it is not known how presentation level affects spectrotemporal modulation threshold...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.10.017

    authors: Magits S,Moncada-Torres A,Van Deun L,Wouters J,van Wieringen A,Francart T

    更新日期:2019-01-01 00:00:00

  • The gap-prepulse inhibition deficit of the cortical N1-P2 complex in patients with tinnitus: The effect of gap duration.

    abstract::The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing l...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.03.003

    authors: Ku Y,Ahn JW,Kwon C,Kim DY,Suh MW,Park MK,Lee JH,Oh SH,Kim HC

    更新日期:2017-05-01 00:00:00

  • Quantitative distributions of aspartate aminotransferase and glutaminase activities in the rat cochlea.

    abstract::The intra-cochlear distributions of aspartate aminotransferase and glutaminase, prominent enzymes of aspartate and glutamate metabolism, have been studied by quantitative microchemical techniques. Also measured was choline acetyltransferase, the enzyme synthesizing acetylcholine, and a marker for the olivocochlear bun...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(86)90058-4

    authors: Wiet GJ,Godfrey DA,Ross CD,Dunn JD

    更新日期:1986-01-01 00:00:00

  • Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population.

    abstract:BACKGROUND:Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell c...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.02.007

    authors: Wang B,Ding E,Shen H,Wang J,Sun K,Chen S,Han L,Zhang H,Zhu B,Xu M

    更新日期:2017-04-01 00:00:00

  • Masculinization of the mammalian cochlea.

    abstract::Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2009.01.002

    authors: McFadden D

    更新日期:2009-06-01 00:00:00

  • Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea.

    abstract::Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2006.09.007

    authors: Takeda-Nakazawa H,Harada N,Shen J,Kubo N,Zenner HP,Yamashita T

    更新日期:2007-05-01 00:00:00

  • Measurement of the binaural temporal window using a lateralisation task.

    abstract::Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024micros were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symm...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2008.12.001

    authors: Kolarik AJ,Culling JF

    更新日期:2009-02-01 00:00:00

  • Expression pattern of aquaporin water channels in the inner ear of the rat. The molecular basis for a water regulation system in the endolymphatic sac.

    abstract::Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great functional significance, we investigated the expression patterns of a...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00036-2

    authors: Beitz E,Kumagami H,Krippeit-Drews P,Ruppersberg JP,Schultz JE

    更新日期:1999-06-01 00:00:00

  • Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI.

    abstract::Functional magnetic resonance imaging is a noninvasive and nonradioactive method for the detection of focal brain activity. In the present study the auditory cortex was investigated in nine normal subjects who were binaurally stimulated using pulsed sine tones of 500 Hz and 4000 Hz. The BOLD (blood oxygenation level d...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00139-7

    authors: Bilecen D,Scheffler K,Schmid N,Tschopp K,Seelig J

    更新日期:1998-12-01 00:00:00

  • Acoustically induced hearing loss: intracellular studies in the guinea pig cochlea.

    abstract::Intracellular recordings were made from both inner and outer hair cells (IHC, OHC) in the basal coil of the guinea pig cochlea before, during and after the animal was exposed to loud, pure tones. Following multiple loud tones both types of sensory cells demonstrate a culmulative decrease in their voltage responses to ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90040-8

    authors: Cody AR,Russell IJ

    更新日期:1988-09-01 00:00:00

  • Endocochlear potential in focal lesions of the guinea pig cochlea.

    abstract::To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00204-4

    authors: Wu R,Hoshino T,Nagura M

    更新日期:1999-02-01 00:00:00

  • Otoacoustic emission in myasthenia gravis patients and the role of efferent activation.

    abstract::We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for th...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00154-3

    authors: Tóth L,Rácz T,Diószeghy P,Répássy G,Lampé I

    更新日期:1998-12-01 00:00:00

  • Biochemical evidence for the presence of serotonin transporters in the rat cochlea.

    abstract::Cochlear serotonergic innervation is constituted by efferent fibers projecting both to the area below the inner and the outer hair cells. Previous detection of serotonin (5-HT) metabolites and 5-HT receptor mRNAs suggests the existence of serotonergic synaptic activity in the cochlea. The present study explores this p...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00140-0

    authors: Vicente-Torres MA,Dávila D,Bartolomé MV,Carricondo F,Gil-Loyzaga P

    更新日期:2003-08-01 00:00:00

  • Histological and physiological effects of the central auditory prosthesis: surface versus penetrating electrodes.

    abstract::To rehabilitate profoundly deaf patients who are not suitable for cochlear implants, central auditory prostheses have been implanted. To compare two possible electrode configurations - penetrating and surface ones - electrical stimulation of the cochlear nucleus with both types of arrays was tested on guinea pigs and ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(97)00170-6

    authors: Liu X,McPhee G,Seldon HL,Clark GM

    更新日期:1997-12-01 00:00:00

  • A method for calibration of bone driver transducers to measure the mastoid impedance.

    abstract::When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.02.013

    authors: Weece R,Allen J

    更新日期:2010-05-01 00:00:00