Abstract:
:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in the parvalbumin family and possible identity with the mammalian beta-parvalbumin oncomodulin. As shown herein, the latter conclusion is supported by strong cross-reactivity between CBP-15 and isoform-specific antibodies to oncomodulin. Moreover, we have succeeded in amplifying the guinea pig CBP-15 coding sequence from organ of Corti cDNA using degenerate oligonucleotide primers based on the rat oncomodulin sequence. The deduced amino acid sequence of guinea pig CBP-15 displays 90%, 92%, and 98% identity with mouse, rat, and human oncomodulin isoforms. Demonstration of the presence of oncomodulin in the organ of Corti is the first documentation of this substance in a postnatal mammalian tissue.
journal_name
Hear Resjournal_title
Hearing researchauthors
Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann Rdoi
10.1016/s0378-5955(97)00005-1subject
Has Abstractpub_date
1997-04-01 00:00:00pages
105-11issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(97)00005-1journal_volume
106pub_type
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