Abstract:
:Transtympanic administration of gentamicin is a widely accepted and effective approach for treating patients with intractable vertigo. Previous studies have demonstrated the uptake, distribution and effects of gentamicin in peripheral vestibular and cochlear structures after transtympanic injection. However, little is known about whether transtympanically administered gentamicin is trafficked into more central auditory and vestibular structures and its effect on these structures. In this study, we used immunofluorescence to determine the distribution of gentamicin within the auditory and vestibular brainstem. We observed gentamicin immunolabeling bilaterally in the vestibular efferent neurons, and in the superior olivary complex, and ipsilaterally in the cochlear nucleus 24h after transtympanic administration of gentamicin, and that the drug could still be detected in these locations 30 days after injection. In contrast, no gentamicin labeling was detected in the vestibular nuclear complex. In the vestibular efferent neurons and superior olivary complex, gentamicin labeling was detected in the cytoplasm and cell processes, while in the cochlear nucleus gentamicin is mainly localized outside and adjacent to the cell bodies of neurons. Nerve fibers in cochlear nucleus, root of eighth nerve, as well as descending pathways from the superior olivary complex, are also immunolabeled with gentamicin continuously. Based on these data, we hypothesize that retrograde axonal transport of gentamicin is responsible for the distribution of gentamicin in these efferent nuclei including vestibular efferent neurons and superior olivary complex and anterograde axonal transport into the ipsilateral cochlear nucleus.
journal_name
Hear Resjournal_title
Hearing researchauthors
Zhang YB,Zhang R,Zhang WF,Steyger PS,Dai CFdoi
10.1016/j.heares.2011.10.003subject
Has Abstractpub_date
2012-01-01 00:00:00pages
169-79issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(11)00250-4journal_volume
283pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Auditory brainstem implants (ABIs) can restore useful hearing to persons with deafness who cannot benefit from cochlear implants. However, the quality of hearing restored by ABIs rarely is comparable to that provided by cochlear implants in persons for whom those are appropriate. In an animal model, we evaluated eleme...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.03.009
更新日期:2018-06-01 00:00:00
abstract::Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode arra...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2010.03.006
更新日期:2010-06-14 00:00:00
abstract::We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00154-3
更新日期:1998-12-01 00:00:00
abstract::The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00150-7
更新日期:2000-10-01 00:00:00
abstract::Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00208-2
更新日期:2001-01-01 00:00:00
abstract::This report describes a study that took advantage of the unique reactivity of the patas monkey (Erythrocebus patas) to dihydrostreptomycin-sulfate (DHSM) to investigate the effects of selective outer hair cell (OHC) lesions on psychophysical tuning curves (PTC). Four patas monkeys were trained using operant reinforcem...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90161-4
更新日期:1987-01-01 00:00:00
abstract::The nascent tectorial membrane (TM) is identifiable as early as stage 33 (7th day) as thin, wispy material. By stage 37 (11th day), the dense mesh of the immature TM and fibrous webs (subtectorial threads) that attach the TM to the basilar papilla are distinct but scanty. The TM condenses slightly in its upper face. T...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90108-x
更新日期:1985-04-01 00:00:00
abstract::This paper describes the development of a protocol that can be used to detect collagen II in the healthy adult basilar membrane (BM) at the electron microscopic level. This protocol required aggressive epitope exposure techniques to break the crosslinks that bind the collagen molecules tightly into fibrils and to remo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00313-1
更新日期:2002-04-01 00:00:00
abstract::High doses of salicylate induce reversible tinnitus in experimental animals and humans, and is a common tinnitus model. Salicylate probably acts centrally and induces hyperactivity in specific auditory brainstem areas like the dorsal cochlear nucleus (DCN). However, little is known about the effect of high doses of sa...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.10.008
更新日期:2016-02-01 00:00:00
abstract::Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.12.009
更新日期:2012-02-01 00:00:00
abstract::Efferent auditory feedback on cochlear hair cells is well studied regarding olivocochlear brainstem mechanisms. Less is known about how the descending corticofugal system may shape efferent feedback and modulate cochlear mechanics. Distortion-product otoacoustic emissions (DPOAEs) are a suitable tool to assess outer h...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.11.008
更新日期:2016-02-01 00:00:00
abstract::Several electrophysiological and psychophysical studies have shown that the spatial excitation pattern produced by bipolar stimulation of a cochlear implant (CI) can have a dual-peak shape. The perceptual effects of this dual-peak shape were investigated using noise-vocoded CI simulations in which synthesis filters we...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.11.001
更新日期:2015-01-01 00:00:00
abstract::The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.05.005
更新日期:2013-11-01 00:00:00
abstract::The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90116-5
更新日期:1992-05-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2006.06.004
更新日期:2007-04-01 00:00:00
abstract::Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.01.008
更新日期:2016-05-01 00:00:00
abstract::Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the co...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.01.007
更新日期:2018-04-01 00:00:00
abstract::Noise trauma, aging, and ototoxicity preferentially damage the outer hair cells of the inner ear, leading to increased hearing thresholds and poorer frequency resolution. Whereas outer hair cells make synaptic connections with less than 10% of afferent auditory nerve fibers (type-II), inner hair cells make connections...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.03.012
更新日期:2013-08-01 00:00:00
abstract::This study investigated the relation between the intelligibility of conversational and clear speech produced by older and younger adults and (a) the acoustic profile of their speech (b) communication effectiveness. Speech samples from 30 talkers from the elderLUCID corpus were used: 10 young adults (YA), 10 older adul...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.06.009
更新日期:2018-11-01 00:00:00
abstract::We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(82)90052-1
更新日期:1982-02-01 00:00:00
abstract::The analysis of the auditory scene begins from the moment we hear sounds, making it possible for the infant to distinguish the mother's voice from other sounds in the environment. The purpose of the study was to determine, in two experiments, whether the frequency separation threshold, at which the perception of a mix...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.12.013
更新日期:2007-03-01 00:00:00
abstract::Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(91)90219-y
更新日期:1991-05-01 00:00:00
abstract::A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90140-v
更新日期:1993-04-01 00:00:00
abstract::Pairs of single units were recorded simultaneously from the same microelectrode in the medial geniculate body (MGB) of nitrous oxide anaesthetized cats. Crosscorrelation histograms of each spike train pairs were computed and distributed in five main classes, interpreted in terms of functional interaction between neigh...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90093-1
更新日期:1987-01-01 00:00:00
abstract::The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.01.024
更新日期:2019-06-01 00:00:00
abstract::Gamma-aminobutyric acid (GABA)-like immunoreactivity in the chick basilar papilla and lagenar macula was studied by using anti-serum against GABA coupled with glutaraldehyde to bovine serum albumin. GABA-like immunoreactivity was localized selectively in the cytoplasm of both tall and short hair cells in the basilar p...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90178-x
更新日期:1987-01-01 00:00:00
abstract::A number of studies have shown that the ear can be protected from sound over-exposure, either by activating the cochlear efferent system, or by sound 'conditioning' in which the role of the efferent system is less certain. To study more definitively the molecular basis of deliberately induced cochlear protection from ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00265-9
更新日期:2001-06-01 00:00:00
abstract::Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarizati...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.03.009
更新日期:2005-07-01 00:00:00
abstract::A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the wh...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.08.008
更新日期:2008-11-01 00:00:00
abstract::Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00332-0
更新日期:2004-01-01 00:00:00