Abstract：
:Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode array insertion. In this experiment, a second turn cochleostomy and implantation was performed on guinea pigs, to examine protection in the basal turn without the confounding effect of local trauma, as well as to test the efficacy of hearing protection in the second cochlear turn. The implantation resulted in an increase in hearing thresholds across all frequencies examined (2-32 kHz). Local delivery of dexamethasone to the round window prior to implantation protected hearing across frequencies from 2 to 32 kHz. Auditory thresholds improved over the first week after surgery, and then remained stable for the month of the experiment. The protection of hearing in the basal turn increased with longer periods of drug application prior to implantation. The level of hearing protection in the second turn was similar irrespective of the time that the drug was applied, but was greater when a higher steroid concentration was used. It was concluded that steroids protect hearing in the basal turn of the cochlea even when there was no local trauma. The level of hearing protection in the second turn exceeded that expected from models of steroid diffusion through the cochlea, suggesting that inner ear surgery alters the distribution of dexamethasone within the cochlea.
journal_name
Hear Resjournal_title
Hearing researchauthors
Eastwood H,Chang A,Kel G,Sly D,Richardson R,O'Leary SJdoi
10.1016/j.heares.2010.03.006subject
Has Abstractpub_date
2010-06-14 00:00:00pages
25-9issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(10)00071-7journal_volume
265pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarizati...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.03.009
更新日期：2005-07-01 00:00:00
abstract：:Certain characteristics of the extracellular cochlear microphonic (CM) recorded by intracochlear electrodes change in a bimodal manner as a function of prior acoustic exposure, intensity of stimulation, or stimulus frequency. In the present study, it is shown that biasing the basilar membrane position toward scala tym...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90036-2
更新日期：1980-03-01 00:00:00
abstract：:The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.04.010
更新日期：2014-07-01 00:00:00
abstract：:Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00260-4
更新日期：2001-03-01 00:00:00
abstract：:Despite the common use of guinea pigs in investigations of the neural mechanisms of binaural and spatial hearing, their behavioral capabilities in spatial hearing tasks have surprisingly not been thoroughly investigated. To begin to fill this void, we tested the spatial hearing of adult male guinea pigs in several exp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.04.011
更新日期：2018-08-01 00:00:00
abstract：:Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.05.013
更新日期：2005-11-01 00:00:00
abstract：:An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.02.011
更新日期：2006-05-01 00:00:00
abstract：:Acoustic signals are extensively used for guiding various behaviors in frogs such as vocalization and phonotaxis. While numerous studies have investigated the anatomy and physiology of the auditory system, our knowledge of intrinsic properties and connectivity of individual auditory neurons remains poor. Moreover, the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00081-1
更新日期：1998-08-01 00:00:00
abstract：:Glutamate has been implicated in signal transmission between inner hair cells and afferent fibers of the organ of Corti. The inner hair cells are enriched in glutamate and the postsynaptic membranes express AMPA glutamate receptors. However, it is not known whether inner hair cells contain a mechanism for glutamate re...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.07.005
更新日期：2012-10-01 00:00:00
abstract：:When hearing thresholds are measured with high-frequency resolution there is a pseudo-periodic variation in thresholds across frequency of up to 15-20dB. This variation is called threshold fine structure (previously referred to as threshold microstructure). Consequently, estimates of auditory status based on threshold...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.011
更新日期：2012-01-01 00:00:00
abstract：:Auditory brainstem implants (ABIs) can restore useful hearing to persons with deafness who cannot benefit from cochlear implants. However, the quality of hearing restored by ABIs rarely is comparable to that provided by cochlear implants in persons for whom those are appropriate. In an animal model, we evaluated eleme...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：:In previous studies describing the effects of electrically stimulating the olivocochlear bundle, it seems possible that both medial and lateral (MOC and LOC) efferents may have been stimulated. To selectively stimulate MOC efferents, we used an electrode placed at the origin of the MOC efferents in the brainstem (MOC ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90023-8
更新日期：1988-05-01 00:00:00
abstract：:The Frequency-Following Response (FFR) is a neurophonic auditory evoked potential that reflects the efficient encoding of speech sounds and is disrupted in a range of speech and language disorders. This raises the possibility to use it as a potential biomarker for literacy impairment. However, reference values for com...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00204-4
更新日期：1999-02-01 00:00:00
abstract：:Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as those with impaired audiograms. This study investigates the applicability of subco...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.07.001
更新日期：2019-09-01 00:00:00
abstract：:The course, distribution and termination of single efferent fibers to the cochlea has been described in only a few animals and relatively few fibers have been studied with knowledge of their ipsilateral or contralateral origin. In order to examine the efferent fibers in the mouse, the anterograde tracer Phaseolus vulg...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90096-r
更新日期：1991-09-01 00:00:00
abstract：:Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90015-8
更新日期：1986-01-01 00:00:00
abstract：:The understanding of speech in noise relies (at least partially) on spectrotemporal modulation sensitivity. This sensitivity can be measured by spectral ripple tests, which can be administered at different presentation levels. However, it is not known how presentation level affects spectrotemporal modulation threshold...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.10.017
更新日期：2019-01-01 00:00:00
abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:DFNB4 is non-syndromic, autosomal recessive type of hearing loss with an enlarged vestibular aqueduct (EVA) caused by mutations in SLC26A4/pendrin. Although the characteristics of hearing loss are well known in DFNB4, vestibular function remains inconclusive. We evaluated the vestibular function of 31 patients with bi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.02.009
更新日期：2016-05-01 00:00:00
abstract：:To investigate the audio-vocal feedback responses of (F0) to hearing amplification in severe-to-profound prelingual hearing loss (SPHL) using power spectral analysis of F0 contour of sustained vowels. Sustained phonations of vowel/a/of seventeen participants with SPHL were acquired with and without hearing-aid amplifi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.04.010
更新日期：2013-08-01 00:00:00
abstract：:Acoustic distortion has been measured from the ear canals of guinea pigs treated with the aminoglycoside antibiotic gentamicin. The correlation between pre- and post-treatment levels of distortion can be related to the extent of outer hair cell (OHC) pathology induced by gentamicin. All animals that were treated and s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90140-8
更新日期：1989-11-01 00:00:00
abstract：:Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(95)00154-7
更新日期：1995-10-01 00:00:00
abstract：:The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells. We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tiss...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.07.021
更新日期：2015-12-01 00:00:00
abstract：:An investigation of the effects of the level and bandwidth of the masking noise and of the effect of test-tone duration on binaural masking-level differences (BMLDs) has been carried out using the standard Békésy audiometric techniques. The BMLDs increase in magnitude with increasing masker level, reach a shallow maxi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90015-7
更新日期：1984-05-01 00:00:00
abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00038-1
更新日期：2000-06-01 00:00:00
abstract：:The ultrastructure of the sensory epithelia in the auditory regions of the ear, the sacculus and lagena, were investigated in the blue gourami, Trichogaster trichopterus, using transmission and scanning electron microscopy. The sensory epithelium consists of sensory hair cells surrounded by supporting cells, both of w...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(81)90049-6
更新日期：1981-11-01 00:00:00
abstract：:High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2012.11.016
更新日期：2013-01-01 00:00:00
abstract：:Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00132-8
更新日期：1995-09-01 00:00:00
abstract：:Until recently the responses of the mechanosensitive hair cells of the cochlea have been inferred from their morphology, morphological relationships with other structures in the cochlea, and by indirect electrophysiological measurements. With the advent of techniques for making intracellular recordings from hair cells...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90096-1
更新日期：1986-01-01 00:00:00
