Abstract:
:Acoustic distortion has been measured from the ear canals of guinea pigs treated with the aminoglycoside antibiotic gentamicin. The correlation between pre- and post-treatment levels of distortion can be related to the extent of outer hair cell (OHC) pathology induced by gentamicin. All animals that were treated and show functional changes also show changes in OHC morphology. Changes in distortion properties are evident before clear changes in surface hair cell morphology are seen. In the early stages of intoxication, thin sections of the organ of Corti are necessary to reveal the underlying structural changes accompanying functional impairment. Where OHCs have been affected by gentamicin treatment, the greatest change in 2f1-f2 level is for distortion generated by widely spaced stimuli. With closely spaced stimuli, 2f1-f2 may be unchanged in level, but higher order distortion components are depressed. Functional evidence of mild OHC disruption is only revealed by stimulus levels at or below 60 dB SPL. With higher sound levels, apparently normal levels of distortion can be generated by ears in which there is clear evidence of OHC pathology. In a single, untreated animal with an extensive basal turn lesion, some 2f1-f2 distortion was generated when the stimulus frequency region lacked OHCs.
journal_name
Hear Resjournal_title
Hearing researchauthors
Brown AM,McDowell B,Forge Adoi
10.1016/0378-5955(89)90140-8subject
Has Abstractpub_date
1989-11-01 00:00:00pages
143-56issue
2-3eissn
0378-5955issn
1878-5891pii
0378-5955(89)90140-8journal_volume
42pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90098-1
更新日期:1994-06-01 00:00:00
abstract::Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90187-t
更新日期:1990-04-01 00:00:00
abstract::Gerbils are frequently used in auditory research; however, only limited information on the exact frequency representation in the cochlea is available. Therefore the place-frequency map of the gerbil was determined by iontophoretic application of horseradish peroxidase in physiologically characterized single auditory n...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00230-8
更新日期:1996-05-01 00:00:00
abstract::For the purpose of creating a finite element model of the middle ear, the ossicles can be modelled as rigid bodies or as linear elastic materials. The general elasticity parameters used are usually measured on larger bones like the femur. In order to obtain a highly realistic model, the actual elastic modulus (Young's...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.10.001
更新日期:2010-05-01 00:00:00
abstract::When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2010.02.013
更新日期:2010-05-01 00:00:00
abstract::The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.04.010
更新日期:2014-07-01 00:00:00
abstract::Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(00)00127-1
更新日期:2000-09-01 00:00:00
abstract::Sound-induced displacement responses in the plane of the organ of Corti were studied in the apical turn in the isolated temporal-bone preparation of the guinea-pig cochlea. Swept sinusoidal sound stimuli (100-500 Hz) were delivered closed-field to the external auditory meatus. The surface of the organ of Corti was con...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00002-l
更新日期:1995-03-01 00:00:00
abstract::The role of glycine and GABA as inhibitory neurotransmitters in the adult vertebrate nervous system has been well characterized in a variety of model systems, including the auditory, which is particularly well suited for analyzing inhibitory neurotransmission. However, a full understanding of glycinergic and GABAergic...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2011.05.012
更新日期:2011-09-01 00:00:00
abstract::Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00339-8
更新日期:2002-07-01 00:00:00
abstract::Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.11.007
更新日期:2012-01-01 00:00:00
abstract::Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00132-8
更新日期:1995-09-01 00:00:00
abstract::Harmonic complex tones are a particularly important class of sounds found in both speech and music. Although these sounds contain multiple frequency components, they are usually perceived as a coherent whole, with a pitch corresponding to the fundamental frequency (F0). However, when two or more harmonic sounds occur ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2009.09.012
更新日期:2010-07-01 00:00:00
abstract::A three-dimensional computer simulation of the experiment (Benser M. E., Issa N.P., Hudspeth A.J., 1993. Hear. Res. 68, 243-252), devoted to the mechanical stimulation of the surface of saccular membrane of bullfrog with the otoconial mass removed was carried out by finite-element method. Comparison of the calculated ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00034-4
更新日期:2000-05-01 00:00:00
abstract::Carboplatin preferentially destroys inner hair cells (IHCs) in the chinchilla inner ear, while retaining a near-normal outer hair cell (OHC) population. The present study investigated the functional consequences of IHC loss on the compound action potential (CAP), inferior colliculus potential (ICP) and auditory cortex...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00171-9
更新日期:2000-01-01 00:00:00
abstract::An investigation of the effects of the level and bandwidth of the masking noise and of the effect of test-tone duration on binaural masking-level differences (BMLDs) has been carried out using the standard Békésy audiometric techniques. The BMLDs increase in magnitude with increasing masker level, reach a shallow maxi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(84)90015-7
更新日期:1984-05-01 00:00:00
abstract::There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00151-1
更新日期:1995-10-01 00:00:00
abstract::Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.09.010
更新日期:2019-01-01 00:00:00
abstract::Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00076-7
更新日期:1996-09-15 00:00:00
abstract::It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.06.006
更新日期:2011-12-01 00:00:00
abstract::Glass microelectrodes were introduced into the stria vascularis (SV) to measure the DC potential profile of the SV in vivo from its apical as well as basal side. The K+ concentration gradient in the lateral cochlear wall was measured by means of double barrel K+-selective microelectrodes. A positive potential 10.4 +/-...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90077-3
更新日期:1987-01-01 00:00:00
abstract::This review is concerned with the operation of circuits in the central auditory system, how they transform response features and what functional significance may be attributed to those transformations. We focus on the role that GABAergic inhibition plays in processing interaural intensity disparities (IIDs), the princ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(02)00362-3
更新日期:2002-06-01 00:00:00
abstract::Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00252-0
更新日期:2001-05-01 00:00:00
abstract::The effect of interaural time differences (ITDs) on stream segregation for successive tone bursts was investigated. Obligatory stream segregation was inferred from the threshold for detecting a rhythmic irregularity in an otherwise isochronous sequence of interleaved "A" and "B" tones (task 1). Subjective stream segre...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.06.006
更新日期:2012-09-01 00:00:00
abstract::Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acoustic maskers and vice versa. Masking effects in acoustic hearing are generally att...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.107873
更新日期:2020-02-01 00:00:00
abstract::Tinnitus is a perception of sound that can occur in the absence of an external stimulus. A brief review of electroencephalography (EEG) and magnetoencephalography (MEG) literature demonstrates that there is no clear relationship between tinnitus presence and frequency band power in whole scalp or source oscillatory ac...
journal_title:Hearing research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.heares.2015.11.003
更新日期:2016-01-01 00:00:00
abstract::Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00802-x
更新日期:2003-03-01 00:00:00
abstract::The nature of age-related improvements in auditory sensitivity was explored by comparing behavioral and auditory brainstem response (ABR) thresholds in 3- and 6-month-old infants and in adults. Thresholds were estimated for tone pips at 1, 4, and 8 kHz, presented at a rate of 13.3/s. The time course of development of ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90071-8
更新日期:1993-06-01 00:00:00
abstract::The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce auto-immune hearing loss. To determine if CTL2/SLC44A2 also has roles in inner ear development and to distinguish between isoform-specific roles, we assessed age-re...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.09.004
更新日期:2011-12-01 00:00:00
abstract::The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory st...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2016.05.018
更新日期:2017-01-01 00:00:00