Abstract：
:An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to hold charge after cessation of a pulse. When a spiral ganglion cell with a cell body was simulated, the value of tau(sum) was elevated at the peripheral node adjacent to the cell body. For refraction pulses, the refraction time constant, tau(ref), indicates the duration of the relative refractory period of the membrane. In spiral ganglion cell simulations, tau(ref) was decreased at the peripheral node adjacent to the cell body and slightly elevated at other peripheral nodes. The extent of the cell body influence on tau(sum) and tau(ref) was high localized. Excitation times for the nodes adjacent to the cell body were either simultaneous or near simultaneous resulting in similar response latencies. Results indicate that values of tau(sum) and tau(ref) may be useful for distinguishing central and peripheral excitation sites while latency measures alone are not a good indication of site of excitation.
journal_name
Hear Resjournal_title
Hearing researchauthors
Cartee LAdoi
10.1016/j.heares.2006.02.011subject
Has Abstractpub_date
2006-05-01 00:00:00pages
22-30issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(06)00067-0journal_volume
215pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:Noise trauma, aging, and ototoxicity preferentially damage the outer hair cells of the inner ear, leading to increased hearing thresholds and poorer frequency resolution. Whereas outer hair cells make synaptic connections with less than 10% of afferent auditory nerve fibers (type-II), inner hair cells make connections...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.03.012
更新日期：2013-08-01 00:00:00
abstract：:Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.010
更新日期：2012-01-01 00:00:00
abstract：:Aldosterone-Type I and dexamethasone-Type II/IB receptor complexes were identified in cytosol prepared from both cochlear and vestibular tissue samples. The specific binding capacity of Type I receptors in the cochlear tissues was approximately equal to that in the vestibular tissues. Likewise, the binding capacity of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90013-0
更新日期：1989-09-01 00:00:00
abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.03.007
更新日期：2009-07-01 00:00:00
abstract：:Measurements were made of inner hair cell receptor potentials and basilar membrane motion in the 17-21 kHz region of the guinea pig cochlea. The latter were made using the Mossbauer technique. Isoamplitude curves at 0.9 mV d.c. receptor potential were compared with isovelocity curves at 0.04 mm/s and the corresponding...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90019-9
更新日期：1983-04-01 00:00:00
abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00095-l
更新日期：1995-08-01 00:00:00
abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90086-5
更新日期：1989-05-01 00:00:00
abstract：:Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.09.001
更新日期：2008-11-01 00:00:00
abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00339-2
更新日期：2001-10-01 00:00:00
abstract：:A common problem among the elderly is a difficulty in discriminating speech sounds. One factor that may contribute to this is a deterioration in the ability to process dynamic aspects of speech such as formant transitions. For the aging auditory system, this deterioration in temporal processing speed may be manifest a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00294-5
更新日期：2001-08-01 00:00:00
abstract：:The ultrastructure of the spiral ligament was compared in aged and young gerbils to assess the involvement of connective tissues in the lateral wall and particularly the fibrocytes in development of presbyacusis. Pathologic features in fibrocytes of senescent gerbils spanned a wide range reflecting different stages of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00581-6
更新日期：2002-10-01 00:00:00
abstract：:Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2016.11.008
更新日期：2017-06-01 00:00:00
abstract：:Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00077-5
更新日期：1999-09-01 00:00:00
abstract：:A large sample of threshold tuning curves of single units from various levels of the auditory pathway was used in order to examine the relationship between best frequency and a measure of sharpness of tuning. This measure is simply the tuning curve bandwidth at 20 dB above threshold on a square-root scale of frequency...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90070-9
更新日期：1983-09-01 00:00:00
abstract：:The relation between hearing loss and loss of hair cells after prolonged exposure to a simulated industrial noise environment was determined in normotensive albino rats. Hearing loss was assessed behaviorally by a conditioned suppression technique and electrophysiologically by auditory brainstem response to pulses of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90129-8
更新日期：1987-01-01 00:00:00
abstract：:Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.001
更新日期：2010-03-01 00:00:00
abstract：:Acoustic signals are extensively used for guiding various behaviors in frogs such as vocalization and phonotaxis. While numerous studies have investigated the anatomy and physiology of the auditory system, our knowledge of intrinsic properties and connectivity of individual auditory neurons remains poor. Moreover, the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00081-1
更新日期：1998-08-01 00:00:00
abstract：:Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.02.006
更新日期：2019-04-01 00:00:00
abstract：:The scalp distributions of middle latency auditory evoked potentials (MAEPs) elicited by tone bursts of 250 and 4000 Hz were compared in two experiments. Na (19.9 ms), Pa (29.8 ms), and Pb (51.4 ms) components elicited by tones of either frequency had fronto-central distributions, whereas the Nb component (38.4 ms) wa...
journal_title：Hearing research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5955(95)00035-3
更新日期：1995-05-01 00:00:00
abstract：:In order to determine the place-frequency map of the rat cochlea, iontophoretic HRP-injections were made into the cochlear nucleus at electrophysiologically characterized positions. Distribution of retrograde HRP transport in cochlear spiral ganglion cells was analysed by means of a three dimensional reconstruction of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90041-7
更新日期：1991-02-01 00:00:00
abstract：:Spectral analysis of electrical noise recorded from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and changes in the spectral characteristics...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.02.006
更新日期：2004-06-01 00:00:00
abstract：:Progress in drug delivery to the ear has been achieved over the last few years. This review illustrates the main mechanisms of controlled drug release and the resulting geometry- and size-dependent release kinetics. The potency, physicochemical properties, and stability of the drug molecules are key parameters for des...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2018.03.006
更新日期：2018-10-01 00:00:00
abstract：:Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as those with impaired audiograms. This study investigates the applicability of subco...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.07.001
更新日期：2019-09-01 00:00:00
abstract：:A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00078-6
更新日期：1997-08-01 00:00:00
abstract：:Subjective tinnitus may be defined as the perceptual correlate of altered spontaneous neural activity occurring in the absence of an externally evoking auditory stimulus. Tinnitus can be caused or exacerbated by one or more of five forms of stress. We propose and provide evidence supporting a model that explains, but ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(00)00235-5
更新日期：2001-02-01 00:00:00
abstract：:Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00332-0
更新日期：2004-01-01 00:00:00
abstract：:Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.09.007
更新日期：2007-05-01 00:00:00
abstract：:Within auditory pathways, the intrinsic electrical properties of neurons, and in particular their complement of potassium channels, play a key role in shaping the timing and pattern of action potentials produced by sound stimuli. The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00117-9
更新日期：2000-09-01 00:00:00
abstract：:We have analyzed a model for the motion of hair bundles of hair cells at high frequencies. In the model, hair-cell organs are represented as a system of rigid mechanical structures surrounded by fluid. A rigid body, that represents a hair bundle, is hinged to a vibrating plate that represents the sensory epithelium. T...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90197-w
更新日期：1990-09-01 00:00:00
