Tetraethylammonium effects on cochlear potentials in the guinea pig.


:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP the perilymphatic perfusion technique was used to introduce the K(+)-channel blocker tetraethylammonium (TEA) into the cochlea. Sound-evoked cochlear potentials were measured subsequently. Without blocking nerve activity TEA induced reversible shifts of the SP in the negative direction, irrespective of whether we recorded from scala vestibuli or scala tympani. Shifts in the negative direction were probably due to TEA acting directly on the afferent fibres, since removal of nerve activity by the potent Na(+)-channel blocker tetrodotoxin (TTX) prevented TEA from shifting the SP in the negative direction. Once nerve activity had been removed by TTX, administration of TEA caused a small decrease in the magnitude of the SP, both in scala vestibuli and in scala tympani, irrespective of its polarity. The decrease was significant for the highest test frequencies only (8-12 kHz), and completely reversible. The rapidly activated K+ channel in the inner hair cell (IHC) is probably blocked by TEA and this blocking might be responsible for the small decrease in magnitude of the SP. The asymmetric contribution from this K+ channel to the IHC's current-voltage relationship seems to be only partly responsible for the generation of the SP, since blocking of this K+ channel with TEA caused relatively small decreases in the amplitude of the SP. TEA did not affect the endocochlear potential.


Hear Res


Hearing research


van Emst MG,Klis SF,Smoorenburg GF




Has Abstract


1995-08-01 00:00:00














  • Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis.

    abstract::Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Takeuchi S,Ando M,Sato T,Kakigi A

    更新日期:2001-05-01 00:00:00

  • Eardrum and columella displacement in single ossicle ears under quasi-static pressure variations.

    abstract::Although most birds encounter large pressure variations during flight, motion of the middle ear components as a result of changing ambient pressure are not well known or described. In the present study, motion of the columella footplate and tympanic membrane (extrastapedius) in domestic chickens (Gallus gallus domesti...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Claes R,Muyshondt PGG,Van Assche F,Van Hoorebeke L,Aerts P,Dirckx JJJ

    更新日期:2018-08-01 00:00:00

  • Investigation of musicality in birdsong.

    abstract::Songbirds spend much of their time learning, producing, and listening to complex vocal sequences we call songs. Songs are learned via cultural transmission, and singing, usually by males, has a strong impact on the behavioral state of the listeners, often promoting affiliation, pair bonding, or aggression. What is it ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Rothenberg D,Roeske TC,Voss HU,Naguib M,Tchernichovski O

    更新日期:2014-02-01 00:00:00

  • Auditory evoked potentials in aged gerbils: responses elicited by noises separated by a silent gap.

    abstract::The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Boettcher FA,Mills JH,Swerdloff JL,Holley BL

    更新日期:1996-12-01 00:00:00

  • A review of the progress and pitfalls of FDA policy process: Planning a pathway for pharmaceutical interventions for hearing loss development.

    abstract::The Federal Food and Drug Administration, or FDA is generally considered a powerful gatekeeper, able to deliver or withhold life-saving cures and create or destroy economic windfalls. As the decades go by, and technologies, diseases, public health demands, and politics evolve, we can identify patterns of change, actio...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Hammill TL

    更新日期:2017-06-01 00:00:00

  • Volume gradients in inner hair cell-auditory nerve fiber pre- and postsynaptic proteins differ across mouse strains.

    abstract::In different animal models, auditory nerve fibers display variation in spontaneous activity and response threshold. Functional and structural differences among inner hair cell ribbon synapses are believed to contribute to this variation. The relative volumes of synaptic proteins at individual synapses might be one suc...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Reijntjes DOJ,Köppl C,Pyott SJ

    更新日期:2020-05-01 00:00:00

  • Efferent neurons to the macular lagena in the embryonic chick.

    abstract::The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Code RA

    更新日期:1995-01-01 00:00:00

  • Transganglionic transport of D-aspartate from cochlear nucleus to cochlea--a quantitative autoradiographic study.

    abstract::This study concerns the connections of the inner and outer hair cells and the different types of ganglion cells of the mammalian cochlea with the central nervous system by making use of their putative neurotransmitters. D-[3H]Aspartate (D-ASP), a putative marker for glutamatergic neurons, was injected into the cochlea...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Jones DR,Morest DK,Oliver DL,Potashner SJ

    更新日期:1984-09-01 00:00:00

  • Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users.

    abstract:BACKGROUND:Pitch perception of complex tones relies on place or temporal fine structure-based mechanisms from resolved harmonics and the temporal envelope of unresolved harmonics. Combining this information is essential for speech-in-noise performance, as it allows segregation of a target speaker from background noise....

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bonnard D,Schwalje A,Gantz B,Choi I

    更新日期:2018-09-01 00:00:00

  • Distortion in the cochlea: acoustic f2-f1 at low stimulus levels.

    abstract::The stimulus level and frequency dependence of the quadratic difference tone (QDT) measured as an otoacoustic emission in the ear canal has been investigated in the guinea pig and compared with simultaneously measured cubic difference tone (CDT) and with the round window electrical response. Acoustic QDT level tended ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Brown AM

    更新日期:1993-11-01 00:00:00

  • Plastic changes along auditory pathway during salicylate-induced ototoxicity: Hyperactivity and CF shifts.

    abstract::High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Jiang C,Luo B,Manohar S,Chen GD,Salvi R

    更新日期:2017-04-01 00:00:00

  • The influence of pneumococcal otitis media on the cochlear lateral wall.

    abstract::The cochlear influence of otitis media was investigated in order to identify damaged regions causing cochlear malfunction. BALB/c mice were challenged with viable Streptococcus pneumoniae into the middle ear cavity and were killed 1 day to 1 month later for immunohistochemical analysis. Otitis media was induced in all...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Ichimiya I,Suzuki M,Hirano T,Mogi G

    更新日期:1999-05-01 00:00:00

  • The relationship between noise-induced hearing loss and hair cell loss in rats.

    abstract::Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chen GD,Fechter LD

    更新日期:2003-03-01 00:00:00

  • Preferential and non-preferential transmission of formant information by an analogue cochlear implant using noise: the role of the nerve threshold.

    abstract::Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Morse RP,Evans EF

    更新日期:1999-07-01 00:00:00

  • Corticofugal Modulation of DPOAEs in Gerbils.

    abstract::Efferent auditory feedback on cochlear hair cells is well studied regarding olivocochlear brainstem mechanisms. Less is known about how the descending corticofugal system may shape efferent feedback and modulate cochlear mechanics. Distortion-product otoacoustic emissions (DPOAEs) are a suitable tool to assess outer h...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Jäger K,Kössl M

    更新日期:2016-02-01 00:00:00

  • Autoradiographic labelling of P2 purinoceptors in the guinea-pig cochlea.

    abstract::Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Mockett BG,Bo X,Housley GD,Thorne PR,Burnstock G

    更新日期:1995-04-01 00:00:00

  • In vitro differentiation of mouse embryo statoacoustic ganglion and sensory epithelium.

    abstract::Interactions between the statoacoustic ganglion and sensory vestibular epithelia have been investigated using different methods of organ and tissue cultures taken from mouse embryos on gestation day 13. Ultrastructural and biochemical observations of the degree of maturation of vestibular sensory cells and ganglion ne...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Raymond J

    更新日期:1987-01-01 00:00:00

  • Reorganization of auditory cortex after neonatal high frequency cochlear hearing loss.

    abstract::Cochleotopic representation in cortex (AI) is extensively reorganized in cats having neonatal, bilateral high frequency cochlear hearing loss. Anterior areas of AI, normally devoted to high frequencies, contain neurons which are almost all tuned to one lower frequency. This frequency corresponds, at the level of the c...

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    pub_type: 杂志文章


    authors: Harrison RV,Nagasawa A,Smith DW,Stanton S,Mount RJ

    更新日期:1991-07-01 00:00:00

  • Neural sensitivity to statistical regularities as a fundamental biological process that underlies auditory learning: the role of musical practice.

    abstract::There is increasing evidence that humans and other nonhuman mammals are sensitive to the statistical structure of auditory input. Indeed, neural sensitivity to statistical regularities seems to be a fundamental biological property underlying auditory learning. In the case of speech, statistical regularities play a cru...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: François C,Schön D

    更新日期:2014-02-01 00:00:00

  • The connexin 30.3 of zebrafish homologue of human connexin 26 may play similar role in the inner ear.

    abstract::The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chang-Chien J,Yen YC,Chien KH,Li SY,Hsu TC,Yang JJ

    更新日期:2014-07-01 00:00:00

  • Summating potential (SP) tuning curves.

    abstract::Two methods were used to extract frequency specific information from the gross d.c. cochlear potential, the summating potential (SP). The first approach was to derive SP tuning curves using a two-tone simultaneous masking procedure; the second to obtain SP iso-response functions. The influence of various parameter cha...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Cheatham MA,Dallos P

    更新日期:1984-11-01 00:00:00

  • Partial amino acid sequences of organ of Corti proteins OCP1 and OCP2: a progress report.

    abstract::Progress in amino acid sequencing of two low-molecular weight acidic proteins of unknown function which are present at high concentrations in the organ of Corti is reported. These two proteins, provisionally termed OCP1 and OCP2, were originally demonstrated by two-dimensional polyacrylamide gel electrophoresis; their...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Thalmann I,Suzuki H,McCourt DW,Comegys TH,Thalmann R

    更新日期:1993-01-01 00:00:00

  • Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

    abstract::Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kane KL,Longo-Guess CM,Gagnon LH,Ding D,Salvi RJ,Johnson KR

    更新日期:2012-01-01 00:00:00

  • Hair-bundle stiffness dominates the elastic reactance to otolithic-membrane shear.

    abstract::Efficient transduction by acousticolateralis organs requires that a stimulus force principally deflect hair bundles, rather than flex other structural elements. Hair bundles might therefore be expected to provide a large fraction of the impedence to shear motions of otolithic membranes and other accessory structures. ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Benser ME,Issa NP,Hudspeth AJ

    更新日期:1993-08-01 00:00:00

  • Auditory capabilities of birds in relation to the structural diversity of the basilar papilla.

    abstract::The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gleich O,Langemann U

    更新日期:2011-03-01 00:00:00

  • Furosemide has no effect on endocochlear potential and tuning properties of primary afferent fibres in the pigeon inner ear.

    abstract::In the pigeon no influence of high doses (135 mg/kg) of furosemide on endocochlear potential and sound evoked activity in single auditory nerve fibres was found. This finding contrasts strongly to results in mammals. ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Schermuly L,Vossieck T,Klinke R

    更新日期:1990-12-01 00:00:00

  • Hyperpolarization-activated current (Ih) in primary auditory neurons.

    abstract::A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chen C

    更新日期:1997-08-01 00:00:00

  • A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV).

    abstract::Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

    更新日期:2004-01-01 00:00:00

  • Gentamicin is ototoxic to all hair cells in the fish lateral line system.

    abstract::Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Van Trump WJ,Coombs S,Duncan K,McHenry MJ

    更新日期:2010-03-01 00:00:00

  • Morphometric changes in the cochlear nucleus in patients who had undergone cochlear implantation for bilateral profound deafness.

    abstract::We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chao TK,Burgess BJ,Eddington DK,Nadol JB Jr

    更新日期:2002-12-01 00:00:00