Tetraethylammonium effects on cochlear potentials in the guinea pig.


:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP the perilymphatic perfusion technique was used to introduce the K(+)-channel blocker tetraethylammonium (TEA) into the cochlea. Sound-evoked cochlear potentials were measured subsequently. Without blocking nerve activity TEA induced reversible shifts of the SP in the negative direction, irrespective of whether we recorded from scala vestibuli or scala tympani. Shifts in the negative direction were probably due to TEA acting directly on the afferent fibres, since removal of nerve activity by the potent Na(+)-channel blocker tetrodotoxin (TTX) prevented TEA from shifting the SP in the negative direction. Once nerve activity had been removed by TTX, administration of TEA caused a small decrease in the magnitude of the SP, both in scala vestibuli and in scala tympani, irrespective of its polarity. The decrease was significant for the highest test frequencies only (8-12 kHz), and completely reversible. The rapidly activated K+ channel in the inner hair cell (IHC) is probably blocked by TEA and this blocking might be responsible for the small decrease in magnitude of the SP. The asymmetric contribution from this K+ channel to the IHC's current-voltage relationship seems to be only partly responsible for the generation of the SP, since blocking of this K+ channel with TEA caused relatively small decreases in the amplitude of the SP. TEA did not affect the endocochlear potential.


Hear Res


Hearing research


van Emst MG,Klis SF,Smoorenburg GF




Has Abstract


1995-08-01 00:00:00














  • Brain dynamics encode the spectrotemporal boundaries of auditory objects.

    abstract::Perception of objects in the scene around us is effortless and intuitive, yet entails profound computational challenges. Progress has been made in understanding some mechanisms by which the brain encodes the boundaries and surfaces of visual objects. However, in the auditory domain, these mechanisms are poorly underst...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: McMullan AR,Hambrook DA,Tata MS

    更新日期:2013-10-01 00:00:00

  • Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner ear.

    abstract::Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Hayashi H,Kunisada T,Takakura N,Aoki M,Mizuta K,Ito Y

    更新日期:2008-11-01 00:00:00

  • Pure tone thresholds for the rhesus monkey.

    abstract::Auditory thresholds were measured for 18 ears from 13 rhesus monkeys using a simple reaction-time procedure. The threshold contour was a smooth W-shaped function with rises at the extreme frequencies and around 4 kHz and was comparable in shape with previously reported thresholds for this animal. Standard deviations a...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pfingst BE,Laycock J,Flammino F,Lonsbury-Martin B,Martin G

    更新日期:1978-10-01 00:00:00

  • The cochlear place-frequency map of the adult and developing Mongolian gerbil.

    abstract::Gerbils are frequently used in auditory research; however, only limited information on the exact frequency representation in the cochlea is available. Therefore the place-frequency map of the gerbil was determined by iontophoretic application of horseradish peroxidase in physiologically characterized single auditory n...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Müller M

    更新日期:1996-05-01 00:00:00

  • Spiral ganglion cell site of excitation II: numerical model analysis.

    abstract::An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Cartee LA

    更新日期:2006-05-01 00:00:00

  • Effect of acoustic similarity on short-term auditory memory in the monkey.

    abstract::Recent evidence suggests that the monkey's short-term memory in audition depends on a passively retained sensory trace as opposed to a trace reactivated from long-term memory for use in working memory. Reliance on a passive sensory trace could render memory particularly susceptible to confusion between sounds that are...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Scott BH,Mishkin M,Yin P

    更新日期:2013-04-01 00:00:00

  • Standardised profiling for tinnitus research: The European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

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    journal_title:Hearing research

    pub_type: 杂志文章,多中心研究


    authors: Genitsaridi E,Partyka M,Gallus S,Lopez-Escamez JA,Schecklmann M,Mielczarek M,Trpchevska N,Santacruz JL,Schoisswohl S,Riha C,Lourenco M,Biswas R,Liyanage N,Cederroth CR,Perez-Carpena P,Devos J,Fuller T,Edvall NK,Hellbe

    更新日期:2019-06-01 00:00:00

  • Cortical responses to amplitude modulation in guinea pigs and the effects of general anesthesia by pentobarbital.

    abstract::Test of amplitude modulation detection threshold against modulation frequency (Mf) is one of the major measures in behavior studies for exploring temporal acuity of the auditory system. In this experiment, we recorded cortical responses from implanted electrodes in guinea pigs to generate temporal modulation transfer ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Feng Y,Yin S,Wang J

    更新日期:2009-01-01 00:00:00

  • Differential thresholds of local field potentials and unit discharges in rat auditory cortex.

    abstract::Thresholds for responses to tone bursts in the primary auditory field of pentobarbital-anesthetized rat are significantly lower for local field potentials (5.60 dB+/-1.76 S.E.M.) than for multiple unit discharges (17.80 dB+/-3.17), recorded simultaneously from the same microelectrode. The characteristic frequencies (C...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Galván VV,Chen J,Weinberger NM

    更新日期:2002-05-01 00:00:00

  • Objective auditory threshold estimation using sine-wave derived responses.

    abstract::A derived response method of acquiring frequency specific auditory evoked potentials that utilizes a pure tone in combination with a toneburst is applied to the measurement of hearing sensitivity in guinea pigs, chinchillas and pocket gophers. Two experiments which demonstrate that thresholds acquired via tone-derived...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Hood LJ,Berlin CI,Heffner RS,Morehouse CR,Smith EG,Barlow EK

    更新日期:1991-09-01 00:00:00

  • Cochlear frequency-place map in adult chickens: intracellular biocytin labeling.

    abstract::A cochlear frequency-place map was developed for adult chickens by labeling cochlear ganglion neurons with biocytin and correlating the location of each labeled fiber along the basilar papilla with the characteristic frequency of the unit's tuning curve. Labeled fibers showed little or no branching within the sensory ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chen L,Salvi R,Shero M

    更新日期:1994-12-01 00:00:00

  • Roles of inhibition for transforming binaural properties in the brainstem auditory system.

    abstract::This review is concerned with the operation of circuits in the central auditory system, how they transform response features and what functional significance may be attributed to those transformations. We focus on the role that GABAergic inhibition plays in processing interaural intensity disparities (IIDs), the princ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Pollak GD,Burger RM,Park TJ,Klug A,Bauer EE

    更新日期:2002-06-01 00:00:00

  • Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. III. Tuning curves and thresholds at CF.

    abstract::In order to study the effects of efferent activity, olivocochlear efferents were stimulated with an electrode in the fourth ventricle at the decussation of the crossed olivocochlear bundle (midline-OCB stimulation) or with an electrode at the brainstem origin of medial efferents (MOC stimulation). Tuning curves, or si...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Guinan JJ Jr,Gifford ML

    更新日期:1988-12-01 00:00:00

  • Morphology and axonal projection patterns of auditory neurons in the midbrain of the painted frog, Discoglossus pictus.

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Luksch H,Walkowiak W

    更新日期:1998-08-01 00:00:00

  • Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea.

    abstract::Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Takeda-Nakazawa H,Harada N,Shen J,Kubo N,Zenner HP,Yamashita T

    更新日期:2007-05-01 00:00:00

  • Functional localization of auditory cortical fields of human: click-train stimulation.

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Brugge JF,Volkov IO,Oya H,Kawasaki H,Reale RA,Fenoy A,Steinschneider M,Howard MA 3rd

    更新日期:2008-04-01 00:00:00

  • Analysis of non-linear cochlear mechanics in the marsupial Monodelphis domestica: ancestral and modern mammalian features.

    abstract::The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Faulstich M,Kössl M,Reimer K

    更新日期:1996-05-01 00:00:00

  • Improving speech perception in noise with current focusing in cochlear implant users.

    abstract::Cochlear implant (CI) users typically have excellent speech recognition in quiet but struggle with understanding speech in noise. It is thought that broad current spread from stimulating electrodes causes adjacent electrodes to activate overlapping populations of neurons which results in interactions across adjacent c...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Srinivasan AG,Padilla M,Shannon RV,Landsberger DM

    更新日期:2013-05-01 00:00:00

  • Noise induces A1 adenosine receptor expression in the chinchilla cochlea.

    abstract::Adenosine plays a major cytoprotective role during ischemia and conditions of oxidative stress. Previous studies in our laboratory indicate that oxidative stress induces expression of the A1 adenosine receptor (A1AR) via activation of nuclear factor (NF)-kappaB. In this study, we tested whether noise exposure could in...

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    pub_type: 杂志文章


    authors: Ramkumar V,Whitworth CA,Pingle SC,Hughes LF,Rybak LP

    更新日期:2004-02-01 00:00:00

  • Chronic electrical stimulation does not prevent spiral ganglion cell degeneration in deafened guinea pigs.

    abstract::Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant use...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Agterberg MJ,Versnel H,de Groot JC,van den Broek M,Klis SF

    更新日期:2010-10-01 00:00:00

  • Expression of heregulin and ErbB/Her receptors in adult chinchilla cochlear and vestibular sensory epithelium.

    abstract::Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Zhang M,Ding D,Salvi R

    更新日期:2002-07-01 00:00:00

  • Calcification processes in the chick otoconia and calcium binding proteins: patterns of tetracycline incorporation and calbindin-D28K distribution.

    abstract::In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensi...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Balsamo G,Avallone B,Del Genio F,Trapani S,Marmo F

    更新日期:2000-10-01 00:00:00

  • Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus.

    abstract::Animal model research has shown that the central features of tinnitus, the perception of sound without an acoustic correlate, include elevated spontaneous and stimulus-driven activity, enhanced burst-mode firing, decreased variance of inter-spike intervals, and distortion of tonotopic frequency representation. Less we...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Brozoski T,Brozoski D,Wisner K,Bauer C

    更新日期:2017-07-01 00:00:00

  • Measurement of the binaural temporal window using a lateralisation task.

    abstract::Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024micros were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symm...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kolarik AJ,Culling JF

    更新日期:2009-02-01 00:00:00

  • Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.

    abstract::There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quie...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Eckert MA,Harris KC,Lang H,Lewis MA,Schmiedt RA,Schulte BA,Steel KP,Vaden KI Jr,Dubno JR

    更新日期:2020-10-31 00:00:00

  • The auditory neurobiology of marsupials: a review.

    abstract::The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Aitkin L

    更新日期:1995-02-01 00:00:00

  • Functional specialization in non-primary auditory cortex of the cat: areal and laminar contributions to sound localization.

    abstract::The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization; (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Lomber SG,Malhotra S,Hall AJ

    更新日期:2007-07-01 00:00:00

  • Evaluation of distortion products produced by the human auditory system.

    abstract::During the simultaneous monaural presentation of two primary tones, distortion products can be measured acoustically in the ear canal (DPOAEs) and electrically as auditory evoked potentials (DPAEPs). The purpose of this investigation was to elucidate the sources of nonlinearity within the human auditory system respons...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bhagat SP,Champlin CA

    更新日期:2004-07-01 00:00:00

  • K(+) currents produce P(1) in the RW CAP: evidence from DC current bias, K(+) channel blockade and recordings from cochlea and brainstem.

    abstract::Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Brown DJ,McMahon CM,Patuzzi RB

    更新日期:2004-04-01 00:00:00

  • Auditory capabilities of birds in relation to the structural diversity of the basilar papilla.

    abstract::The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gleich O,Langemann U

    更新日期:2011-03-01 00:00:00