Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance.

abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...

journal_title：Hearing research

authors： Sohmer H,Goitein K,Freeman S

更新日期：1994-02-01 00:00:00

abstract：:This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (IHCs) in the chinchilla. Acoustic trauma typically impairs the sensitivity and tuning...

journal_title：Hearing research

authors： Salvi RJ,Wang J,Ding D

更新日期：2000-09-01 00:00:00

abstract：:The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism...

journal_title：Hearing research

authors： Elgoyhen AB,Franchini LF

更新日期：2011-03-01 00:00:00

abstract：:The structure of the tectorial membrane of the chick was evaluated by scanning electron microscopy (SEM), using standard techniques, and, for the first time, by studying unfixed tectorial membranes with video-enhanced light microscopy techniques (AVEC-DIC). The SEM pictures show a widely varying morphology, ranging fr...

journal_title：Hearing research

authors： Runhaar G

更新日期：1989-01-01 00:00:00

abstract：:Two-tone stimuli have traditionally been used to reveal regions of inhibition in auditory spectral receptive fields, particularly for neurons with low spontaneous rates. These techniques reveal how different frequencies excite or suppress the response to an excitatory frequency of a cell, but have often been assessed ...

journal_title：Hearing research

authors： Brimijoin WO,O'Neill WE

更新日期：2005-12-01 00:00:00

abstract：:Perception of objects in the scene around us is effortless and intuitive, yet entails profound computational challenges. Progress has been made in understanding some mechanisms by which the brain encodes the boundaries and surfaces of visual objects. However, in the auditory domain, these mechanisms are poorly underst...

journal_title：Hearing research

authors： McMullan AR,Hambrook DA,Tata MS

更新日期：2013-10-01 00:00:00

abstract：:Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain react...

journal_title：Hearing research

authors： Caravelli A,Pianese L,Saulino C,Di Leva F,Sequino L,Cocozza S,Marciano E,Franzé A

更新日期：2004-12-01 00:00:00

abstract：:Normal-hearing listeners can perceptually segregate concurrent sound sources, but listeners with significant hearing loss or who wear a cochlear implant (CI) lag behind in this ability. Perceptual grouping mechanisms are essential to segregate concurrent sound sources and affect comodulation masking release (CMR). Thu...

journal_title：Hearing research

authors： Zirn S,Hempel JM,Schuster M,Hemmert W

更新日期：2013-02-01 00:00:00

abstract：:Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...

journal_title：Hearing research

authors： Early S,Moon IS,Bommakanti K,Hunter I,Stankovic KM

更新日期：2019-09-15 00:00:00

abstract：:Interactions between the statoacoustic ganglion and sensory vestibular epithelia have been investigated using different methods of organ and tissue cultures taken from mouse embryos on gestation day 13. Ultrastructural and biochemical observations of the degree of maturation of vestibular sensory cells and ganglion ne...

journal_title：Hearing research

authors： Raymond J

更新日期：1987-01-01 00:00:00

abstract：:Although speech understanding is highly variable amongst cochlear implants (CIs) subjects, the remarkably high speech recognition performance of many CI users is unexpected and not well understood. Numerous factors, including neural health and degradation of the spectral information in the speech signal of CIs, likely...

journal_title：Hearing research

authors： Zheng Y,Escabí M,Litovsky RY

更新日期：2017-08-01 00:00:00

abstract：:Echolocation offers a promising approach to improve the quality of life of people with blindness although little is known about the factors influencing object localisation using a 'searching' strategy. In this paper, we describe a series of experiments using sighted and blind human listeners and a 'virtual auditory sp...

journal_title：Hearing research

authors： Rowan D,Papadopoulos T,Edwards D,Holmes H,Hollingdale A,Evans L,Allen R

更新日期：2013-06-01 00:00:00

abstract：:The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

journal_title：Hearing research

authors： Gleich O,Langemann U

更新日期：2011-03-01 00:00:00

abstract：:Little is known about inner ear development in pigeons. This paper addresses the question of maturation in activity patterns of pigeon auditory nerve fibres, Pigeons that were 1, 2 and 4 weeks and 1, 2, 3 and 4 years old were investigated. Adult-like activity patterns are found 4 weeks post-hatching. Spontaneous activ...

journal_title：Hearing research

authors： Richter CP,Sauer G,Hoidis S,Klinke R

更新日期：1996-05-01 00:00:00

abstract：:In ears in which cochlear efferent pathways were cut and with testing done under anaesthetic conditions that preclude middle ear muscle activity (so as to examine the "intrinsic" effects of loud sound on the cochlea without any confounding effect of efferent pathways to the auditory periphery), atraumatic background w...

journal_title：Hearing research

authors： Rajan R

更新日期：2006-03-01 00:00:00

abstract：:Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...

journal_title：Hearing research

authors： Linebarger DA,Johnson DH

更新日期：1986-01-01 00:00:00

abstract：:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...

journal_title：Hearing research

authors： Cohen LT,Richardson LM,Saunders E,Cowan RS

更新日期：2003-05-01 00:00:00

abstract：:A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and ...

journal_title：Hearing research

authors： Rybak LP,Whitworth C

更新日期：1987-01-01 00:00:00

abstract：:Thresholds for pure tones embedded in harmonic complexes were measured behaviorally and physiologically for three species of birds, and physiologically in gerbils. The harmonic maskers were generated using the Schroeder-phase algorithm, characterized by monotonically increasing or decreasing phase across frequency. Pr...

journal_title：Hearing research

authors： Dooling RJ,Dent ML,Leek MR,Gleich O

更新日期：2001-02-01 00:00:00

abstract：:At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduct...

journal_title：Hearing research

authors： Katz E,Verbitsky M,Rothlin CV,Vetter DE,Heinemann SF,Elgoyhen AB

更新日期：2000-03-01 00:00:00

abstract：:Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...

journal_title：Hearing research

authors： Müller M,von Hünerbein K,Hoidis S,Smolders JW

更新日期：2005-04-01 00:00:00

abstract：:The spectro-temporal receptive field (STRF) of an auditory neuron represents those characteristics of the sound stimulus in both the time and frequency domain that affect the firing probability of the neuron. The STRF is determined under stationary stimulus conditions for Gaussian wide-band noise. It has been demonstr...

journal_title：Hearing research

authors： Eggermont JJ,Aertsen AM,Johannesma PI

更新日期：1983-05-01 00:00:00

abstract：:Change in PO2 in endolymph, endocochlear potentials and cochlear microphonics have been tested in normoxia, hyperoxia and anoxia on 24 guinea pigs. The polarographic method and construction of oxygen-sensitive microelectrodes is described in detail. The normal level of PO2 in endolymph vaires between 20 and 30 mm Hg. ...

journal_title：Hearing research

authors： Prazma J,Fischer ND,Biggers WP,Ascher D

更新日期：1978-10-01 00:00:00

abstract：:An analysis of the central projections of the ventral nucleus of the trapezoid body (VNTB) in the rat, a region of the superior olivary complex known for its neuronal heterogeneity, was made using two anterograde axonal tracers, [3H]leucine and biotinylated dextran amine (BDA). A mixture of these tracers was injected ...

journal_title：Hearing research

authors： Warr WB,Beck JE

更新日期：1996-04-01 00:00:00

abstract：:One role of the inferior colliculus (IC) in bats is to create neuronal delay-tuning, which is used for the estimation of target distance in the echolocating bat's auditory system. In this study, we describe response properties of IC delay-tuned neurons of the mustached bat (Pteronotus parnellii) and compare it with th...

journal_title：Hearing research

authors： Macías S,Mora EC,Hechavarría JC,Kössl M

更新日期：2012-04-01 00:00:00

abstract：:Older adults are often reported in the literature to have greater difficulty than younger adults understanding speech in noise [Helfer and Wilber (1988). J. Acoust. Soc. Am, 859-893]. The poorer performance of older adults has been attributed to a general deterioration of cognitive processing, deterioration of cochlea...

journal_title：Hearing research

authors： Gilbertson L,Lutfi RA

更新日期：2014-11-01 00:00:00

abstract：:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the e...

journal_title：Hearing research

authors： Matsuda K,Ueda Y,Doi T,Tono T,Haruta A,Toyama K,Komune S

更新日期：1999-07-01 00:00:00

abstract：:The highest spectral ripple density at which the discrimination of ripple glide direction was possible (STRtdir task) was assessed for one-octave wide (narrowband) stimuli with center frequencies of 500, 1000, 2000, and 4000 Hz and for a broadband stimulus. A pink noise lowpass filtered at the lower edge frequency of ...

journal_title：Hearing research

authors： Narne VK,Jain S,Sharma C,Baer T,Moore BCJ

更新日期：2020-04-01 00:00:00

abstract：:The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same through...

journal_title：Hearing research

authors： Park JC,Hubel SB,Woods AD

更新日期：1987-01-01 00:00:00

abstract：:The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory st...

journal_title：Hearing research

authors： Lesicko AM,Llano DA

更新日期：2017-01-01 00:00:00