Abstract：
:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the expression of GLAST mRNA remained at a high level until 12 days after the completion of the KM treatment, it then fell to the normal level within 2 months. Such KM treatment resulted in loss of both inner and outer hair cells and a concomitant profound permanent threshold shift. The present findings suggest that during KM administration, high concentrations of extracellular glutamate released by collapsing hair cells induced GLAST mRNA expression. Increased GLAST mRNA might play an important role in the prevention of the secondary death of spiral ganglion neurons from glutamate neurotoxicity.
journal_name
Hear Resjournal_title
Hearing researchauthors
Matsuda K,Ueda Y,Doi T,Tono T,Haruta A,Toyama K,Komune Sdoi
10.1016/s0378-5955(99)00050-7keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
10-6issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(99)00050-7journal_volume
133pub_type
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