Abstract：
:Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application of the calcium ionophore ionomycin which induces cortical contractions and elongation of outer hair cells, did not affect the shape of inner hair cells. Since ionomycin increased free intracellular calcium levels in both inner and outer hair cells, the results demonstrate that inner hair cells do not possess the mechanisms necessary for a contractile response to calcium. Thus, calcium is a specific regulator of outer hair cell motility making this mechanism a likely physiological modulator of a transduction feedback process.
journal_name
Hear Resjournal_title
Hearing researchauthors
Dulon D,Zajic G,Schacht Jdoi
10.1016/0378-5955(91)90202-ksubject
Has Abstractpub_date
1991-03-01 00:00:00pages
225-31issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(91)90202-Kjournal_volume
52pub_type
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