Tonotopic mapping in auditory cortex of the chinchilla.

abstract：:Several studies have reported an increased incidence of auditory dysfunction among HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and caspases 3/7-activation studies to investigate the potential ototoxicity of fourteen HIV antiretroviral agents: Abacavir, AZT, Delavirdine, Didenosi...

journal_title：Hearing research

authors： Thein P,Kalinec GM,Park C,Kalinec F

更新日期：2014-04-01 00:00:00

abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...

journal_title：Hearing research

authors： Rouiller EM,Rodrigues-Dagaeff C,Simm G,De Ribaupierre Y,Villa A,De Ribaupierre F

更新日期：1989-05-01 00:00:00

abstract：:A cochlear frequency-place map was developed for adult chickens by labeling cochlear ganglion neurons with biocytin and correlating the location of each labeled fiber along the basilar papilla with the characteristic frequency of the unit's tuning curve. Labeled fibers showed little or no branching within the sensory ...

journal_title：Hearing research

authors： Chen L,Salvi R,Shero M

更新日期：1994-12-01 00:00:00

abstract：:Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ETARs) in glomerular pathogenesis. Here w...

journal_title：Hearing research

authors： Meehan DT,Delimont D,Dufek B,Zallocchi M,Phillips G,Gratton MA,Cosgrove D

更新日期：2016-11-01 00:00:00

abstract：:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...

journal_title：Hearing research

authors： Pirvola U,Arumäe U,Moshnyakov M,Palgi J,Saarma M,Ylikoski J

更新日期：1994-05-01 00:00:00

abstract：:A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the wh...

journal_title：Hearing research

authors： Ehmann H,Salzig C,Lang P,Friauf E,Nothwang HG

更新日期：2008-11-01 00:00:00

abstract：:Action potentials recorded extracellularly from neurons within the caudal cochlear nuclei of developing cats exhibited distinctive temporal characteristics (i.e., rhythmic responses) in response to long-duration acoustic stimuli including both tone and noise bursts. Unlike the homogeneous response characteristics of a...

journal_title：Hearing research

authors： Walsh EJ,McGee J

更新日期：1988-11-01 00:00:00

abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...

journal_title：Hearing research

authors： Maurer J,Heinrich UR,Mann W

更新日期：1994-01-01 00:00:00

abstract：:DFNB4 is non-syndromic, autosomal recessive type of hearing loss with an enlarged vestibular aqueduct (EVA) caused by mutations in SLC26A4/pendrin. Although the characteristics of hearing loss are well known in DFNB4, vestibular function remains inconclusive. We evaluated the vestibular function of 31 patients with bi...

journal_title：Hearing research

authors： Jung J,Seo YW,Choi JY,Kim SH

更新日期：2016-05-01 00:00:00

abstract：:Noise trauma, aging, and ototoxicity preferentially damage the outer hair cells of the inner ear, leading to increased hearing thresholds and poorer frequency resolution. Whereas outer hair cells make synaptic connections with less than 10% of afferent auditory nerve fibers (type-II), inner hair cells make connections...

journal_title：Hearing research

authors： Lobarinas E,Salvi R,Ding D

更新日期：2013-08-01 00:00:00

abstract：:Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal au...

journal_title：Hearing research

authors： Paul BT,Bruce IC,Roberts LE

更新日期：2017-02-01 00:00:00

abstract：:Strial marginal cells are known to take up and metabolize glucose as their main source of metabolic energy. The membrane transport mechanisms for glucose uptake into strial marginal cells, however, are largely unknown. Two types of glucose transporters in mammalian cells have been described, the facilitated glucose tr...

journal_title：Hearing research

authors： Takeuchi S,Ando M

更新日期：1997-12-01 00:00:00

abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...

journal_title：Hearing research

authors： van Emst MG,Klis SF,Smoorenburg GF

更新日期：1995-08-01 00:00:00

abstract：:Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great functional significance, we investigated the expression patterns of a...

journal_title：Hearing research

authors： Beitz E,Kumagami H,Krippeit-Drews P,Ruppersberg JP,Schultz JE

更新日期：1999-06-01 00:00:00

abstract：:The glycoconjugates in the cochlea of the guinea pig were studied by staining samples by the silver methenamine method as well as after periodic acid-Schiff (PAS) staining. Results obtained by the two methods were similar but not identical. The silver methenamine method was much better in terms of resolution. However,...

journal_title：Hearing research

authors： Kawamata S,Igarashi Y

更新日期：1993-05-01 00:00:00

abstract：:The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory st...

journal_title：Hearing research

authors： Lesicko AM,Llano DA

更新日期：2017-01-01 00:00:00

abstract：:In natural environments, temporally complex signals often occur in a background of noise. The neural mechanisms underlying the preservation of temporal sensitivity in background noise are poorly understood. In the present study, we examined the ability of inferior colliculus (IC) units with primary-like and sustained ...

journal_title：Hearing research

authors： Barsz K,Wilson WW,Walton JP

更新日期：2000-12-01 00:00:00

abstract：:Primary afferent activity was recorded from the cochlear ganglion in chicken embryos (Gallus domesticus) at 19 days of incubation (E19). The ganglion was accessed via the recessus scala tympani and impaled with glass micropipettes. Frequency tuning curves were obtained using a computerized threshold tracking procedure...

journal_title：Hearing research

authors： Jones SM,Jones TA

更新日期：1995-02-01 00:00:00

abstract：:Cochlear function was monitored in adult gerbils using distortion product otoacoustic emissions (DPOAE) during intraperitoneal injection of furosemide. All stimulus parameters were varied independently over a wide range, the stimulus frequencies f1 and f2 from 1 to 16 kHz, and the stimulus levels L1 and L2 from 20 to ...

journal_title：Hearing research

authors： Mills DM,Rubel EW

更新日期：1994-06-15 00:00:00

abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...

journal_title：Hearing research

authors： Kirk DL,Moleirinho A,Patuzzi RB

更新日期：1997-10-01 00:00:00

abstract：:The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...

journal_title：Hearing research

authors： Suzuki M,Yamasoba T,Ishibashi T,Miller JM,Kaga K

更新日期：2002-02-01 00:00:00

abstract：:Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, simil...

journal_title：Hearing research

authors： Minami SB,Sha SH,Schacht J

更新日期：2004-12-01 00:00:00

abstract：:The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pul...

journal_title：Hearing research

authors： Hughes ML,Castioni EE,Goehring JL,Baudhuin JL

更新日期：2012-03-01 00:00:00

abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...

journal_title：Hearing research

authors： Orduña I,Mercado E 3rd,Gluck MA,Merzenich MM

更新日期：2001-10-01 00:00:00

abstract：:Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...

journal_title：Hearing research

authors： Ulfendahl M,Flock A,Scarfone E

更新日期：2001-01-01 00:00:00

abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...

journal_title：Hearing research

authors： Sohmer H,Goitein K,Freeman S

更新日期：1994-02-01 00:00:00

abstract：:One of the key components of fully-implantable hearing devices is the implantable microphone. A crucial parameter when characterizing implantable microphones is the acoustic sensitivity, as it is one of the input parameters for the fitting algorithm and influences the achievable gain. The aim of our study was to inves...

journal_title：Hearing research

authors： D'hondt C,Wouters J,Verhaert N

更新日期：2020-09-15 00:00:00

abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...

journal_title：Hearing research

authors： Lefebvre PP,Weber T,Rigo JM,Staecker H,Moonen G,Van De Water TR

更新日期：1992-03-01 00:00:00

abstract：:Guinea pigs were exposed to pure tones of 10 kHz at intensities between 98 and 115 dB SPL for 5-30 min, to produce varying degrees of acoustic trauma. Changes in auditory thresholds were measured electrophysiologically, and the animals were immediately fixed for scanning electron microscopy. Correlation between morpho...

journal_title：Hearing research

authors： Clark JA,Pickles JO

更新日期：1996-09-15 00:00:00

abstract：:This study investigated the relation between the intelligibility of conversational and clear speech produced by older and younger adults and (a) the acoustic profile of their speech (b) communication effectiveness. Speech samples from 30 talkers from the elderLUCID corpus were used: 10 young adults (YA), 10 older adul...

journal_title：Hearing research

authors： Hazan V,Tuomainen O,Tu L,Kim J,Davis C,Brungart D,Sheffield B

更新日期：2018-11-01 00:00:00