Abstract:
:In the cochlea, outer hair cells (OHCs) and Deiters' cells most likely contribute to the generation of active cochlear mechanics. The presence of ATP receptors on these cells indicates that endogenous ATP may have a role in cochlear mechanics. To explore this possibility, the effects of ATP antagonists were studied both in vivo on distortion product otoacoustic emissions (DPOAEs) using cochlear perfusion and in vitro on isolated OHCs and Deiters' cells using the whole-cell configuration of the patch-clamp technique. Results show that extracellular application of 5-10 microM ATP to OHCs and Deiters' cells induced an inward current that was reduced by both suramin (100 microM) and cibacron (100 microM). Cibacron reduced the voltage gated currents in Deiters' cells and increased them in OHCs, while suramin had no effect. In addition, cibacron induced a hyperpolarizing shift of the half activation voltage of the whole cell currents in Deiters' cells. Suramin (0.1-1 mM) reversibly suppressed the 'slow decline' in the quadratic DPOAE that occurs during continuous stimulation with moderate level primaries. This effect of suramin may be evidence that endogenous ATP alters active cochlear mechanics.
journal_name
Hear Resjournal_title
Hearing researchauthors
Skellett RA,Chen C,Fallon M,Nenov AP,Bobbin RPdoi
10.1016/s0378-5955(97)00093-2subject
Has Abstractpub_date
1997-09-01 00:00:00pages
42-54issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(97)00093-2journal_volume
111pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::The responses of single units in the ventral cochlear nucleus of acute anesthetized guinea pigs were studied with continuous sinusoidal electrical stimuli presented through a multi-electrode implant in the scala tympani. Implants had two or four electrodes along the axis of the scala with 1 mm separations. Best freque...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90108-9
更新日期:1983-11-01 00:00:00
abstract::Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/0378-5955(95)00154-7
更新日期:1995-10-01 00:00:00
abstract::There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quie...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2020.108109
更新日期:2020-10-31 00:00:00
abstract::Although speech understanding is highly variable amongst cochlear implants (CIs) subjects, the remarkably high speech recognition performance of many CI users is unexpected and not well understood. Numerous factors, including neural health and degradation of the spectral information in the speech signal of CIs, likely...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2017.05.009
更新日期:2017-08-01 00:00:00
abstract::Speech is central to human life. As such, any delay or impairment in receptive speech processing can have a profoundly negative impact on the social and professional life of a person. Thus, being able to assess the integrity of speech processing in different populations is an important goal. Current standardized asses...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2017.02.015
更新日期:2017-05-01 00:00:00
abstract::This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00365-3
更新日期:2001-12-01 00:00:00
abstract::In our companion paper (Le Calvez et al., 1998), the levels of distortion product otoacoustic emissions (DPOAE) were collected in the ears of CD1 mice with progressive degeneration of cochlear outer hair cells (OHC). Their comparison to standard functional measurements such as auditory-evoked brainstem responses (ABR)...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00051-3
更新日期:1998-06-01 00:00:00
abstract::A model was developed to simulate acoustically the effects of excitation spread in cochlear implants (CI). Based on neurophysiologic data, the proposed model simulates the electrical-current decay rate associated with broad and narrow types of excitation, such as those produced by monopolar and bipolar electrode confi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.04.012
更新日期:2008-07-01 00:00:00
abstract::An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.02.011
更新日期:2006-05-01 00:00:00
abstract::The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(88)90045-7
更新日期:1988-09-01 00:00:00
abstract::Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.05.013
更新日期:2005-11-01 00:00:00
abstract::A test of within-channel detection of acoustic temporal fine structure (aTFS) cues is presented. Eight cochlear implant listeners (CI) were asked to discriminate between two Schroeder-phase (SP) complexes using a two-alternative, forced-choice task. Because differences between the acoustic stimuli are primarily constr...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.01.004
更新日期:2013-04-01 00:00:00
abstract::A large sample of threshold tuning curves of single units from various levels of the auditory pathway was used in order to examine the relationship between best frequency and a measure of sharpness of tuning. This measure is simply the tuning curve bandwidth at 20 dB above threshold on a square-root scale of frequency...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90070-9
更新日期:1983-09-01 00:00:00
abstract::Transtympanic administration of gentamicin is a widely accepted and effective approach for treating patients with intractable vertigo. Previous studies have demonstrated the uptake, distribution and effects of gentamicin in peripheral vestibular and cochlear structures after transtympanic injection. However, little is...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.10.003
更新日期:2012-01-01 00:00:00
abstract::This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (IHCs) in the chinchilla. Acoustic trauma typically impairs the sensitivity and tuning...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(00)00136-2
更新日期:2000-09-01 00:00:00
abstract::The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization; (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2007.01.013
更新日期:2007-07-01 00:00:00
abstract::Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.108068
更新日期:2020-10-01 00:00:00
abstract::Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00024-x
更新日期:1995-04-01 00:00:00
abstract::We are studying the interconnections between the anteroventral cochlear nucleus (AVCN) and the dorsal cochlear nucleus (DCN). Biotinylated dextran was injected into the DCN, where the best frequency of responses was also recorded. Ventrotubercular neurons in AVCN were labeled, along with cochlear nerve fibers and the ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00224-x
更新日期:1999-04-01 00:00:00
abstract::The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00160-8
更新日期:1997-01-01 00:00:00
abstract::Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. W...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.11.012
更新日期:2019-01-01 00:00:00
abstract::Auditory cortex exhibit a capacity of modulating the functions of subcortical auditory nuclei and even inner ear through descending pathways. The cochlear nucleus (CN), which acts as the gateway from the auditory periphery to the central auditory system, is also subjected to corticofugal modulation. Cortical modulatio...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.12.013
更新日期:2019-03-01 00:00:00
abstract::The suppression tuning properties of the oto-acoustic distortion product emission, 2f1-f2 have been measured in the ear canal of gerbil and man. The results show the acoustic response to be suppressible in a similar, frequency-dependent manner in both species. Frequencies near to those of the stimulating tones are mos...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(84)90092-3
更新日期:1984-01-01 00:00:00
abstract::Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00191-6
更新日期:2003-08-01 00:00:00
abstract::Frequency discrimination thresholds were measured from five chinchillas for harmonic tone complexes having a fundamental frequency of 250 Hz. Stimuli consisted of the fundamental frequency and the second through 10th harmonics with individual components added in either cosine phase or random phase. In general, thresho...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00171-4
更新日期:2000-11-01 00:00:00
abstract::No adequate theory for the signal-transmission properties of the peripheral auditory system exists for any vertebrate ear. Because the mammalian ear seems to pose conceptual and technical problems that complicate the development of an adequate theory, it is worthwhile to investigate simpler ears. The ear of the alliga...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90164-9
更新日期:1985-01-01 00:00:00
abstract::Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00451-3
更新日期:2002-08-01 00:00:00
abstract::Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction i...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.10.006
更新日期:2010-01-01 00:00:00
abstract::The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00232-4
更新日期:1996-05-01 00:00:00
abstract::We have analyzed a model for the motion of hair bundles of hair cells at high frequencies. In the model, hair-cell organs are represented as a system of rigid mechanical structures surrounded by fluid. A rigid body, that represents a hair bundle, is hinged to a vibrating plate that represents the sensory epithelium. T...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90197-w
更新日期:1990-09-01 00:00:00