Stress induces transient auditory hypersensitivity in rats.

Abstract:

:Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction in exposed animals. In addition to the activated hypothalamic-pituitary-adrenal (HPA) axis, exposed animals had pathological reactions in the reproductive organs, bronchia and skin. Here, we examined the effect of above stress model on the auditory system of Wistar rats. We found that 24-h stress decreases the thresholds and increases the amplitudes of auditory brainstem responses and distortion product otoacoustic emissions. Resultant auditory hypersensitivity was transient and most pronounced between 3 and 6h post-stress, returning to control levels one week later. The concentration of corticosterone and tumor necrosis factor alpha was systemically elevated in stressed animals between 3 and 6h post-stress, confirming the activation of the HPA axis. In addition, expression of the HPA-axis-associated genes: glucocorticoid receptor (GR) and hypoxia-inducible factor 1 alpha (Hif1a) was modulated in the auditory tissues. In detail, in the inferior colliculus, we found an up-regulation of GR mRNA 3h post-stress and continuous up-regulation of Hif1a up to 24h post-stress. In the spiral ganglion, we found no differences in gene expression between stressed and control animals. In the organ of Corti, expression of GR mRNA remained stable, whereas that of Hif1a was significantly down-regulated one week after stress. In addition, the expression of an outer hair cell marker prestin was significantly up-regulated 6h post-stress. We conclude that 24-h stress induces transient hypersensitivity of the auditory system and modulates gene expression in a tissue-specific manner. Stress-induced auditory hypersensitivity could have evolutionary consequence by giving animals an advantage of hearing better under stress conditions.

journal_name

Hear Res

journal_title

Hearing research

authors

Mazurek B,Haupt H,Joachim R,Klapp BF,Stöver T,Szczepek AJ

doi

10.1016/j.heares.2009.10.006

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

55-63

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(09)00251-2

journal_volume

259

pub_type

杂志文章
  • Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.

    abstract::Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiolog...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.11.010

    authors: Clinard CG,Tremblay KL,Krishnan AR

    更新日期:2010-06-01 00:00:00

  • First appearance and development of electromotility in neonatal gerbil outer hair cells.

    abstract::With the purpose of pinpointing the time of onset of electromotility, outer hair cells (OHCs) from apical and basal turns of the cochleae of postnatal gerbils, ranging in age from 6 to 19 days, were isolated and drawn into a glass microchamber. Length changes evoked by transcellular electrical stimulation were detecte...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90046-9

    authors: He DZ,Evans BN,Dallos P

    更新日期:1994-07-01 00:00:00

  • The order of testing effect in otoacoustic emissions and its consequences for sex and ear differences in neonates.

    abstract::The amplitude values of transient-evoked otoacoustic emissions, recorded from a large sample of neonates, were used to examine the asymmetry between ears tested and the differences due to the sex of the subject. Whilst the sex difference, with females having larger responses than males, has been a consistent finding i...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00234-x

    authors: Thornton AR,Marotta N,Kennedy CR

    更新日期:2003-10-01 00:00:00

  • Optical coherence tomographic measurements of the sound-induced motion of the ossicular chain in chinchillas: Additional modes of ossicular motion enhance the mechanical response of the chinchilla middle ear at higher frequencies.

    abstract::Wavelength-swept optical coherence tomography (OCT) was used to scan the structure of cadaveric chinchilla ears in three dimensions with high spatial resolution and measure the sound-induced displacements of the entire OCT-visible lateral surfaces of the ossicles in the lateral-to-medial direction. The simultaneous me...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.108056

    authors: Rosowski JJ,Ramier A,Cheng JT,Yun SH

    更新日期:2020-10-01 00:00:00

  • Analysis of non-linear cochlear mechanics in the marsupial Monodelphis domestica: ancestral and modern mammalian features.

    abstract::The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(95)00232-4

    authors: Faulstich M,Kössl M,Reimer K

    更新日期:1996-05-01 00:00:00

  • A hydromechanical model of the cochlea with nonlinear feedback using PVF2 bending transducers.

    abstract::A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90140-v

    authors: Lechner TP

    更新日期:1993-04-01 00:00:00

  • Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits.

    abstract::The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interfere...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00119-7

    authors: Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

    更新日期:1999-10-01 00:00:00

  • A biochemical model of peripheral tinnitus.

    abstract::Subjective tinnitus may be defined as the perceptual correlate of altered spontaneous neural activity occurring in the absence of an externally evoking auditory stimulus. Tinnitus can be caused or exacerbated by one or more of five forms of stress. We propose and provide evidence supporting a model that explains, but ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5955(00)00235-5

    authors: Sahley TL,Nodar RH

    更新日期:2001-02-01 00:00:00

  • Partial amino acid sequences of organ of Corti proteins OCP1 and OCP2: a progress report.

    abstract::Progress in amino acid sequencing of two low-molecular weight acidic proteins of unknown function which are present at high concentrations in the organ of Corti is reported. These two proteins, provisionally termed OCP1 and OCP2, were originally demonstrated by two-dimensional polyacrylamide gel electrophoresis; their...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90005-l

    authors: Thalmann I,Suzuki H,McCourt DW,Comegys TH,Thalmann R

    更新日期:1993-01-01 00:00:00

  • A physiological place-frequency map of the cochlea in the CBA/J mouse.

    abstract::Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.08.011

    authors: Müller M,von Hünerbein K,Hoidis S,Smolders JW

    更新日期:2005-04-01 00:00:00

  • AM-111 protects against permanent hearing loss from impulse noise trauma.

    abstract::The otoprotective peptide AM-111, a cell-permeable inhibitor of JNK mediated apoptosis, was tested for its efficacy as a rescue agent following impulse noise trauma. Single dose administrations of AM-111 at 1h or 4h post-impulse noise exposure (155 dB peak SPL) via systemic or local routes were evaluated with a total ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2006.05.006

    authors: Coleman JK,Littlesunday C,Jackson R,Meyer T

    更新日期:2007-04-01 00:00:00

  • Auditory nerve fibers in young and quiet-aged gerbils: morphometric correlations with endocochlear potential.

    abstract::The number, size and distribution of myelinated nerve fibers were analyzed in the osseous spiral lamina (OSL) of young and old gerbils raised in a quiet environment. Because decreased endocochlear potentials (EPs) play a significant role in age-related hearing loss in the gerbil, we correlated morphometric and topogra...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(01)00340-9

    authors: Suryadevara AC,Schulte BA,Schmiedt RA,Slepecky NB

    更新日期:2001-11-01 00:00:00

  • Prediction of the responses of auditory neurons in the midbrain of the grass frog based on the spectro-temporal receptive field.

    abstract::The spectro-temporal receptive field (STRF) of an auditory neuron represents those characteristics of the sound stimulus in both the time and frequency domain that affect the firing probability of the neuron. The STRF is determined under stationary stimulus conditions for Gaussian wide-band noise. It has been demonstr...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(83)90053-9

    authors: Eggermont JJ,Aertsen AM,Johannesma PI

    更新日期:1983-05-01 00:00:00

  • Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions.

    abstract::Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(91)90202-k

    authors: Dulon D,Zajic G,Schacht J

    更新日期:1991-03-01 00:00:00

  • Synapses on human spiral ganglion cells: a transmission electron microscopy and immunohistochemical study.

    abstract::A transmission electron microscopy (TEM) study and synaptophysin immunoreactivity analysis of neurons in the human spiral ganglion was performed with particular emphasis on the demonstration of synapses. The study was based on surgical biopsy material obtained during transcochlear meningioma surgery. Vesiculated nerve...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00179-3

    authors: Rask-Andersen H,Tylstedt S,Kinnefors A,Illing R

    更新日期:2000-03-01 00:00:00

  • Viral vectors for gene delivery to the inner ear.

    abstract::Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2020.107927

    authors: Maguire CA,Corey DP

    更新日期:2020-09-01 00:00:00

  • Down-regulation of otospiralin mRNA in response to acoustic stress in guinea pig.

    abstract::Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain react...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.07.011

    authors: Caravelli A,Pianese L,Saulino C,Di Leva F,Sequino L,Cocozza S,Marciano E,Franzé A

    更新日期:2004-12-01 00:00:00

  • Induced suppression in spike responses to tone-on-noise stimuli in the auditory nerve of the pigeon.

    abstract::Spike potentials were recorded from single, afferent fibres in the pigeon auditory nerve. Pure-tone stimuli were presented in quiet and in combination with wide band noise. Presented alone, tones produced tuned response areas; noise generally drove spike rate to well above the spontaneous rate measured in quiet. When ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(89)90081-6

    authors: Hill KG,Mo J,Stange G

    更新日期:1989-05-01 00:00:00

  • Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear.

    abstract::Receptors which bind the neurotrophins NGF, BDNF, NT-3 and NT-4/5 were shown to be present in cochlear and vestibular ganglion cells during development, implying a neurotrophic role for these molecules in the inner ear. We have found by in situ hybridization that cochlear and vestibular sensory epithelial cells expres...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90286-0

    authors: Schecterson LC,Bothwell M

    更新日期:1994-02-01 00:00:00

  • Pure tone thresholds for the rhesus monkey.

    abstract::Auditory thresholds were measured for 18 ears from 13 rhesus monkeys using a simple reaction-time procedure. The threshold contour was a smooth W-shaped function with rises at the extreme frequencies and around 4 kHz and was comparable in shape with previously reported thresholds for this animal. Standard deviations a...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(78)90008-4

    authors: Pfingst BE,Laycock J,Flammino F,Lonsbury-Martin B,Martin G

    更新日期:1978-10-01 00:00:00

  • Potassium channel gene expression in the rat cochlear nucleus.

    abstract::Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2007.01.024

    authors: Friedland DR,Eernisse R,Popper P

    更新日期:2007-06-01 00:00:00

  • Expression of heregulin and ErbB/Her receptors in adult chinchilla cochlear and vestibular sensory epithelium.

    abstract::Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00339-8

    authors: Zhang M,Ding D,Salvi R

    更新日期:2002-07-01 00:00:00

  • Frequency specificity of amplitude envelope patterns in noise-vocoded speech.

    abstract::We examined the frequency specificity of amplitude envelope patterns in 4 frequency bands, which universally appeared through factor analyses applied to power fluctuations of critical-band filtered speech sounds in 8 different languages/dialects [Ueda and Nakajima (2017). Sci. Rep., 7 (42468)]. A series of 3 perceptua...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.06.005

    authors: Ueda K,Araki T,Nakajima Y

    更新日期:2018-09-01 00:00:00

  • Effect of click intensity on click-evoked otoacoustic emission waveforms: implications for the origin of emissions.

    abstract::The rather shallow growth of click-evoked otoacoustic emissions (CEOAE) with click intensity, namely <1 dB/dB, distinguishes genuine CEOAEs from stimulus artifacts, thereby providing the rationale for the popular 'derived nonlinear recording' method. However, other CEOAE nonlinearities regarding phase or envelope depe...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00745-1

    authors: Carvalho S,Büki B,Bonfils P,Avan P

    更新日期:2003-01-01 00:00:00

  • Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.

    abstract::Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ETARs) in glomerular pathogenesis. Here w...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2016.08.003

    authors: Meehan DT,Delimont D,Dufek B,Zallocchi M,Phillips G,Gratton MA,Cosgrove D

    更新日期:2016-11-01 00:00:00

  • Oncomodulin is abundant in the organ of Corti.

    abstract::A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(97)00005-1

    authors: Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann R

    更新日期:1997-04-01 00:00:00

  • Indexing cortical entrainment to natural speech at the phonemic level: Methodological considerations for applied research.

    abstract::Speech is central to human life. As such, any delay or impairment in receptive speech processing can have a profoundly negative impact on the social and professional life of a person. Thus, being able to assess the integrity of speech processing in different populations is an important goal. Current standardized asses...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.02.015

    authors: Di Liberto GM,Lalor EC

    更新日期:2017-05-01 00:00:00

  • Auditory cortex activation to natural speech and simulated cochlear implant speech measured with functional near-infrared spectroscopy.

    abstract::The primary goal of most cochlear implant procedures is to improve a patient's ability to discriminate speech. To accomplish this, cochlear implants are programmed so as to maximize speech understanding. However, programming a cochlear implant can be an iterative, labor-intensive process that takes place over months. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.11.007

    authors: Pollonini L,Olds C,Abaya H,Bortfeld H,Beauchamp MS,Oghalai JS

    更新日期:2014-03-01 00:00:00

  • Formulae describing frequency selectivity as a function of frequency and level, and their use in calculating excitation patterns.

    abstract::The auditory filter may be considered as a weighting function representing frequency selectivity at a particular centre frequency. Its shape can be derived using the power-spectrum model of masking which assumes: (1) in detecting a signal in a masker the observer uses the single auditory filter giving the highest sign...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90050-5

    authors: Moore BC,Glasberg BR

    更新日期:1987-01-01 00:00:00

  • In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.

    abstract::Otoconia are biomineral particles of microscopic size essential for perception of gravity and maintenance of balance. Millions of older Americans are affected in their mobility, quality of life and in their health by progressive demineralization of otoconia. Currently, no effective means to prevent or counteract this ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.05.019

    authors: Lu W,Zhou D,Freeman JJ,Thalmann I,Ornitz DM,Thalmann R

    更新日期:2010-09-01 00:00:00