Abstract：
:This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (IHCs) in the chinchilla. Acoustic trauma typically impairs the sensitivity and tuning of auditory nerve fibers and reduces the neural output of the cochlea. Surprisingly, our results show that restricted cochlear damage enhances neural activity in the central auditory pathway. Despite a reduction in the auditory-nerve compound action potential (CAP), the local field potential from the inferior colliculus (IC) increases at a faster than normal rate and its maximum amplitude is enhanced at frequencies below the region of hearing loss. To determine if this enhancement was due to loss of sideband inhibition, we recorded from single neurons in the IC and dorsal cochlear nucleus before and after presenting a traumatizing above the unit's characteristic frequency (CF). Following the exposure, some neurons showed substantial broadening of tuning below CF, less inhibition, and a significant increase in discharge rate, consistent with a model involving loss of sideband inhibition. The central auditory system of the chinchilla can be deprived of some of its cochlear inputs by selectively destroying IHCs with carboplatin. Selective IHC loss reduces the amplitude of the CAP without affecting the threshold and tuning of the remaining auditory nerve fibers. Although the output of the cochlea is reduced in proportion to the amount of IHC loss, the IC response shows only a modest amplitude reduction, and remarkably, the response of the auditory cortex is enhanced. These results suggest that the gain of the central auditory pathway can be up- or down regulated to compensate for the amount of neural activity from the cochlea.
journal_name
Hear Resjournal_title
Hearing researchauthors
Salvi RJ,Wang J,Ding Ddoi
10.1016/s0378-5955(00)00136-2keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
261-74issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(00)00136-2journal_volume
147pub_type
杂志文章,评审相关文献
HEARING RESEARCH文献大全abstract：:The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked poten...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107975
更新日期：2021-01-01 00:00:00
abstract：:Speech is central to human life. As such, any delay or impairment in receptive speech processing can have a profoundly negative impact on the social and professional life of a person. Thus, being able to assess the integrity of speech processing in different populations is an important goal. Current standardized asses...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.015
更新日期：2017-05-01 00:00:00
abstract：:The ear of the goldfish (Carassius auratus) contains three otolithic endorgans: the saccule, lagena, and utricle. The saccule has an auditory function in most teleost fishes for whom data are available, and there is evidence that the lagena is also an auditory endorgan in the goldfish. This study was conducted to comp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00207-5
更新日期：2000-03-01 00:00:00
abstract：:Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00260-4
更新日期：2001-03-01 00:00:00
abstract：:Although the neural mechanisms underlying pitch perception are not yet fully understood, there is general agreement that place and temporal representations of pitch are both used by the auditory system. This paper describes a neural network model of pitch perception that integrates both codes of pitch and explores the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.11.005
更新日期：2017-02-01 00:00:00
abstract：:Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.08.011
更新日期：2005-04-01 00:00:00
abstract：:Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00451-3
更新日期：2002-08-01 00:00:00
abstract：:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00119-5
更新日期：1995-09-01 00:00:00
abstract：:We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90237-2
更新日期：1994-03-01 00:00:00
abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90289-5
更新日期：1994-02-01 00:00:00
abstract：:The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specime...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.05.001
更新日期：2012-08-01 00:00:00
abstract：:Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90060-m
更新日期：1991-06-01 00:00:00
abstract：:The ototoxic effects of salicylates, reversible hearing loss and tinnitus, are well documented. However, the pharmacological mechanisms underlying these changes in cochlear function are not well understood. The studies reported here were an investigation of the site and mechanism of salicylate ototoxicity through an e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90144-e
更新日期：1990-06-01 00:00:00
abstract：:This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.007
更新日期：2009-11-01 00:00:00
abstract：:The human auditory brainstem is known to be exquisitely sensitive to fine-grained spectro-temporal differences between speech sound contrasts, and the ability of the brainstem to discriminate between these contrasts is important for speech perception. Recent work has described a novel method for translating brainstem ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：:A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90140-v
更新日期：1993-04-01 00:00:00
abstract：:Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.006
更新日期：2010-03-01 00:00:00
abstract：:Congenital hearing loss (HL) affects about 1 in every 500 infants. Among those affected more than half are caused by genetic mutations. According to the cellular sites affected by mutations in the cochlea, deafness genes could be classified into three major groups: those affecting the function of hair cells and synaps...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.107858
更新日期：2020-09-01 00:00:00
abstract：:In response to low-intensity, low-frequency, phase-locked tonal stimuli with non-alternating polarity, the time-average round window (RW) response of the gerbil is a mixture of the auditory nerve neurophonic (ANN) and cochlear microphonic (CM), with the former often being of equal or greater magnitude than the latter....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00195-5
更新日期：1997-02-01 00:00:00
abstract：:Measurements were made of inner hair cell receptor potentials and basilar membrane motion in the 17-21 kHz region of the guinea pig cochlea. The latter were made using the Mossbauer technique. Isoamplitude curves at 0.9 mV d.c. receptor potential were compared with isovelocity curves at 0.04 mm/s and the corresponding...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90019-9
更新日期：1983-04-01 00:00:00
abstract：:Gross electrical responses to tone bursts were measured in the guinea pig with electrodes located in scala tympani (ST) and scala vestibuli (SV) of the cochlea, on the central portion of the VIIIth nerve fibres in the internal auditory meatus, and on the surface of the cochlear nuclear complex (CN). Intracochlear perf...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00716-5
更新日期：2003-02-01 00:00:00
abstract：:The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pul...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.01.010
更新日期：2012-03-01 00:00:00
abstract：:People with tinnitus report anecdotal difficulties in mental concentration and psychological treatments for tinnitus advise on concentration difficulties and how to manage them. Yet the literature lacks any coherent discussion about what precise theoretical cognitive constructs might be mediating reported concentratio...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2015.10.001
更新日期：2016-02-01 00:00:00
abstract：:This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90246-w
更新日期：1993-05-01 00:00:00
abstract：:This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2011.05.001
更新日期：2011-11-01 00:00:00
abstract：:Delayed acoustic waves have been measured in the sealed ear canal in response to click and tone-burst stimuli. The response shows compressive nonlinearity, evidence for 'active' processing, and frequency tuning. At low sound levels group and phase delays correspond, and represent about 15 waves delay for the mid-frequ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90060-x
更新日期：1980-06-01 00:00:00
abstract：:Echolocation offers a promising approach to improve the quality of life of people with blindness although little is known about the factors influencing object localisation using a 'searching' strategy. In this paper, we describe a series of experiments using sighted and blind human listeners and a 'virtual auditory sp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.03.005
更新日期：2013-06-01 00:00:00
abstract：:Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00063-5
更新日期：1999-07-01 00:00:00
abstract：:The glycoconjugates in the cochlea of the guinea pig were studied by staining samples by the silver methenamine method as well as after periodic acid-Schiff (PAS) staining. Results obtained by the two methods were similar but not identical. The silver methenamine method was much better in terms of resolution. However,...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90234-r
更新日期：1993-05-01 00:00:00
abstract：:This study used immunocytochemical markers for various classes of glial cells to investigate the relationship between glial elements and microcysts in the gerbil auditory system at the light and electron microscopic level. Monoclonal antibodies S-100, GFAP and Rip were used on tissue from 3- and 12-month old animals a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90226-q
更新日期：1993-05-01 00:00:00
