Abstract：
:Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown. Clarification was sought in a systematic modeling study of published data on level-dependent non-linear responses from low characteristic-frequency (CF) auditory-nerve fibers for a broad variety of acoustic stimuli. The MBPNL non-linear I/O model of cochlear frequency analysis (Goldstein, 1990), which incorporates the 2-factor hypothesis, was used to simulate the reported non-linear phenomena. It was found that experiments with paired click stimuli (Goblick and Pfeiffer, 1969) and with octave-band complex tones (Horst et al., 1990), in addition to experiments with single clicks or tones, are sensitive to the phase difference between factors. Surprisingly, the paired-click transient responses require a quadrature phase, while the complex-tone steady-state responses require an antiphase relation. The MBPNL model simulations of all low-CF data surveyed,for simple and complex stimuli, are consistent with a quadrature phase for transient responses and antiphase relation for steady-state responses. It is hypothesized that some adaptive, low-CF, cochlear mechanism, not described by the basic MBPNL model, produces a temporal transition of the '2-factor' response from an initial quadrature relation (tip leading) to a final antiphase relation. New experimental and modeling research guided by this working hypothesis is proposed.
journal_name
Hear Resjournal_title
Hearing researchauthors
Lin T,Goldstein JLdoi
10.1016/0378-5955(95)00154-7subject
Has Abstractpub_date
1995-10-01 00:00:00pages
126-38issue
1-2eissn
0378-5955issn
1878-5891pii
0378-5955(95)00154-7journal_volume
90pub_type
杂志文章,评审相关文献
HEARING RESEARCH文献大全abstract：:Electrophysiological recordings in the dorsal cochlear nucleus (DCN) were conducted to determine the nature of changes in single unit activity following intense sound exposure and how they relate to changes in multiunit activity. Single and multiunit spontaneous discharge rates and auditory response properties were re...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.07.006
更新日期：2009-10-01 00:00:00
abstract：:The purpose of this study was to compare cortical brain responses evoked by amplitude modulated acoustic beats of 3 and 6 Hz in tones of 250 and 1000 Hz with those evoked by their binaural beats counterparts in unmodulated tones to indicate whether the cortical processes involved differ. Event-related potentials (ERPs...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.013
更新日期：2010-04-01 00:00:00
abstract：:The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.12.025
更新日期：2016-10-01 00:00:00
abstract：:Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.12.009
更新日期：2012-02-01 00:00:00
abstract：:Over the last 30 years a wide range of manipulations of auditory input and experience have been shown to result in plasticity in auditory cortical and subcortical structures. The time course of plasticity ranges from very rapid stimulus-specific adaptation to longer-term changes associated with, for example, partial h...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2017.10.011
更新日期：2018-05-01 00:00:00
abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00133-6
更新日期：1998-10-01 00:00:00
abstract：:The goal of the current study was to characterize the normative features of wideband acoustic immittance in children for describing the functional maturation of the middle ear in 5 to 12-year-old children. Absorbance and group delay were measured in adults and three groups of children, 5-6, 7-9 and 10-12-year-olds, in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.029
更新日期：2017-02-01 00:00:00
abstract：:Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.07.017
更新日期：2015-09-01 00:00:00
abstract：:A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.12.013
更新日期：2005-08-01 00:00:00
abstract：:Carboplatin preferentially destroys inner hair cells (IHCs) in the chinchilla inner ear, while retaining a near-normal outer hair cell (OHC) population. The present study investigated the functional consequences of IHC loss on the compound action potential (CAP), inferior colliculus potential (ICP) and auditory cortex...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00171-9
更新日期：2000-01-01 00:00:00
abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90049-7
更新日期：1993-10-01 00:00:00
abstract：:Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00451-3
更新日期：2002-08-01 00:00:00
abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00191-6
更新日期：2003-08-01 00:00:00
abstract：:The purpose of this study was to investigate horizontal plane localization and interaural time difference (ITD) thresholds for 14 adult cochlear implant recipients with hearing preservation in the implanted ear. Localization to broadband noise was assessed in an anechoic chamber with a 33-loudspeaker array extending f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.02.007
更新日期：2014-06-01 00:00:00
abstract：:With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.003
更新日期：2006-02-01 00:00:00
abstract：:The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestatio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.01.024
更新日期：2019-06-01 00:00:00
abstract：:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00096-0
更新日期：2003-05-01 00:00:00
abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90074-6
更新日期：1983-08-01 00:00:00
abstract：:This paper reviews the contributions of von Békésy to psychoacoustics, comparing his findings and interpretations to those that have emerged since his work. The areas covered include the perception of pitch for pure tones and complex tones, the effect of frequency on the apparent location of pure tones, estimation of ...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.04.009
更新日期：2012-11-01 00:00:00
abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.06.012
更新日期：2004-11-01 00:00:00
abstract：:The origins of extrinsic projections to the guinea pig dorsal and ventral cochlear nuclei were identified by examining the retrograde transport of horseradish peroxidase conjugated to wheatgerm agglutinin following its injection into each of these divisions. Major projections originated in periolivary regions of the s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90205-n
更新日期：1991-03-01 00:00:00
abstract：:The tension fibroblasts of the spiral ligament of the mammalian cochlea are thought to create radial tension on the basilar membrane. Their postnatal development was investigated in the gerbil (Meriones unguiculatus) with confocal fluorescence microscopy using phallotoxin as a specific marker for F-actin. In the adult...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00051-8
更新日期：1997-06-01 00:00:00
abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90116-5
更新日期：1992-05-01 00:00:00
abstract：:There are three main cues to sound location: the interaural differences in time (ITD) and level (ILD) as well as the monaural spectral shape cues. These cues are generated by the spatial- and frequency-dependent filtering of propagating sound waves by the head and external ears. Although the chinchilla has been used f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.10.007
更新日期：2011-02-01 00:00:00
abstract：:High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2012.11.016
更新日期：2013-01-01 00:00:00
abstract：:In different animal models, auditory nerve fibers display variation in spontaneous activity and response threshold. Functional and structural differences among inner hair cell ribbon synapses are believed to contribute to this variation. The relative volumes of synaptic proteins at individual synapses might be one suc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107933
更新日期：2020-05-01 00:00:00
abstract：:Change in PO2 in endolymph, endocochlear potentials and cochlear microphonics have been tested in normoxia, hyperoxia and anoxia on 24 guinea pigs. The polarographic method and construction of oxygen-sensitive microelectrodes is described in detail. The normal level of PO2 in endolymph vaires between 20 and 30 mm Hg. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(78)90003-5
更新日期：1978-10-01 00:00:00
abstract：:Recordings were made from 185 neurons in the primary auditory cortex of cats in the age range of 15 to 297 days. A comparison was made between the tuning for click repetition-rate and for amplitude modulation-frequency of a noise burst on the basis of temporal Modulation Transfer Functions (tMTF). 90 of the 185 units ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90212-j
更新日期：1993-02-01 00:00:00
abstract：:This paper reviews some of what is known about ion transport through the cells of the mammalian stria vascularis, and discusses how the endolymph and endocochlear potential in scala media are produced by the stria's main cell types. It discusses the role of each cells' ion transport proteins from an engineering perspe...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2011.01.010
更新日期：2011-07-01 00:00:00
