Abstract：
:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) enables presentation of the 'masker' and 'probe' on different electrodes. In the present method the probe position was fixed, while the masker position was varied across the electrode array. The amplitude of the response to the partially masked probe provides a measure of the amount of masking, which is dependent on the extent of overlap of the excitation regions of the masker and probe. These measurements were performed in seven subjects implanted with the Nucleus 24 cochlear implant system (four with straight and three with Contour electrode arrays), for basal, middle and apical probe electrodes. Similar excitation profiles were obtained using either the standard NRT subtraction paradigm or an alternative 'Miller' method. The excitation profiles were compared with those obtained from psychophysical forward masking and good agreement was found. The widths of electrically evoked compound action potential (ECAP) and forward masking profiles did not differ significantly. Whereas the width of the ECAP measure was significantly correlated with both the maximum comfortable level and the distance of the electrode band from the modiolus, the width of the forward masking profile was not.
journal_name
Hear Resjournal_title
Hearing researchauthors
Cohen LT,Richardson LM,Saunders E,Cowan RSdoi
10.1016/s0378-5955(03)00096-0keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
72-87issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595503000960journal_volume
179pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.01.008
更新日期：2016-05-01 00:00:00
abstract：:Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.09.005
更新日期：2007-12-01 00:00:00
abstract：:When hearing thresholds are measured with high-frequency resolution there is a pseudo-periodic variation in thresholds across frequency of up to 15-20dB. This variation is called threshold fine structure (previously referred to as threshold microstructure). Consequently, estimates of auditory status based on threshold...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.011
更新日期：2012-01-01 00:00:00
abstract：:The etiology of an incidentally discovered temporary threshold shift observed in an experimental animal (Harley guinea pig) is discussed with its potential implications for auditory research. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90041-4
更新日期：1987-01-01 00:00:00
abstract：:In this study 9 human temporal bones from 8 individuals were fixed with Karnovsky solution by perilymphatic perfusion within 1-3 h after death and examined using the "block-surface method' (Spoendlin and Brun, 1974; Spoendlin and Schrott, 1987) and the "micro-dissection method' (Johnsson and Hawkins, 1967). The audiog...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00158-1
更新日期：1995-11-01 00:00:00
abstract：:Experiments on the flow-sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line hair cells and measure how behavior changes. Cobalt chloride (CoCl2) bloc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.04.001
更新日期：2017-07-01 00:00:00
abstract：:Gaumond et al. [(1982) J. Neurophysiol. 48, 856-873] showed in the cat that a multiplicative-intensity model can generally account quite well for reduction of the probability of an auditory-nerve spike by another spike preceding it by 4 to 25 ms, and that for smaller separations there is also an increased latency of t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90093-g
更新日期：1993-09-01 00:00:00
abstract：:Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00211-6
更新日期：1998-03-01 00:00:00
abstract：:The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce auto-immune hearing loss. To determine if CTL2/SLC44A2 also has roles in inner ear development and to distinguish between isoform-specific roles, we assessed age-re...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.004
更新日期：2011-12-01 00:00:00
abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90127-9
更新日期：1992-03-01 00:00:00
abstract：:The highest spectral ripple density at which the discrimination of ripple glide direction was possible (STRtdir task) was assessed for one-octave wide (narrowband) stimuli with center frequencies of 500, 1000, 2000, and 4000 Hz and for a broadband stimulus. A pink noise lowpass filtered at the lower edge frequency of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107910
更新日期：2020-04-01 00:00:00
abstract：:Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2009.01.002
更新日期：2009-06-01 00:00:00
abstract：:Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90187-t
更新日期：1990-04-01 00:00:00
abstract：:The human auditory brainstem is known to be exquisitely sensitive to fine-grained spectro-temporal differences between speech sound contrasts, and the ability of the brainstem to discriminate between these contrasts is important for speech perception. Recent work has described a novel method for translating brainstem ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：:A model is introduced for auditory adaptation based on the stochastic models that are widely documented for birth and death processes and used as a vehicle to review single unit and compound action potential studies as well as various models for adaptation and forward masking. It appears that such a model inherently i...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(85)90110-8
更新日期：1985-04-01 00:00:00
abstract：:Acoustic distortion has been measured from the ear canals of guinea pigs treated with the aminoglycoside antibiotic gentamicin. The correlation between pre- and post-treatment levels of distortion can be related to the extent of outer hair cell (OHC) pathology induced by gentamicin. All animals that were treated and s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90140-8
更新日期：1989-11-01 00:00:00
abstract：:Previous claims that auditory stream segregation occurs in cochlear implant listeners are based on limited evidence. In experiment 1, eight listeners heard tones presented in a 30-s repeating ABA-sequence, with frequencies matching the centre frequencies of the implant's 22 electrodes. Tone A always stimulated electro...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.11.010
更新日期：2007-03-01 00:00:00
abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00128-1
更新日期：1996-11-01 00:00:00
abstract：:The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00164-3
更新日期：2003-07-01 00:00:00
abstract：:Unlike the organ of Corti in mammals, the avian basilar papilla has no distinct populations of hair cells. Instead, there is a continuous change between the extreme forms (tall hair cells = THC, and short hair cells = SHC). The hair-cell innervation pattern is complicated, there being no simple gradient between THC (m...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90048-r
更新日期：1992-08-01 00:00:00
abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90049-7
更新日期：1993-10-01 00:00:00
abstract：:The known structural and functional features of the inferior colliculus provided an advantageous substrate for examining the outcome of neural transplantation. In the present study, tissue from the midbrain tectum of Sprague-Dawley rat fetuses was removed at 15, 16 and 19 days of gestation (E15, E16 and E19), incubate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90123-7
更新日期：1990-05-01 00:00:00
abstract：:Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.08.011
更新日期：2008-11-01 00:00:00
abstract：:The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90189-9
更新日期：1994-04-01 00:00:00
abstract：:Little is known about inner ear development in pigeons. This paper addresses the question of maturation in activity patterns of pigeon auditory nerve fibres, Pigeons that were 1, 2 and 4 weeks and 1, 2, 3 and 4 years old were investigated. Adult-like activity patterns are found 4 weeks post-hatching. Spontaneous activ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(96)00020-2
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Epidemiological studies have shown that women have better high-frequency thresholds than men in virtually all age groups, and that age-related hearing decline starts after 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hyp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.09.009
更新日期：2010-01-01 00:00:00
abstract：:Low-frequency temporal information present in speech is critical for normal perception, however the neural mechanism underlying the differentiation of slow rates in acoustic signals is not known. Data from the rat trigeminal system suggest that the paralemniscal pathway may be specifically tuned to code low-frequency ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.10.009
更新日期：2011-02-01 00:00:00
abstract：:Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90023-x
更新日期：1994-08-01 00:00:00
abstract：:Forward maskers within two frequency-intensity domains are capable of decreasing (enhancing) CAP latency: one region flanks the low frequency tail, the other flanks the tip/high frequency slope regions of the latency tuning curve (TC). By contrast, amplitude enhancement typically does not flank the high frequency slop...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90078-2
更新日期：1992-11-01 00:00:00
abstract：:Thresholds for responses to tone bursts in the primary auditory field of pentobarbital-anesthetized rat are significantly lower for local field potentials (5.60 dB+/-1.76 S.E.M.) than for multiple unit discharges (17.80 dB+/-3.17), recorded simultaneously from the same microelectrode. The characteristic frequencies (C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00333-7
更新日期：2002-05-01 00:00:00
