Quantitative evaluation of myelinated nerve fibres and hair cells in cochleae of humans with age-related high-tone hearing loss.

abstract：:Owing to the advances in transgenic animal technology and the advent of the next-generation sequencing era, over 120 genes causing hereditary hearing loss have been identified by now. In parallel, the field of human gene therapy continues to make exciting and rapid progress, culminating in the recent approval of sever...

journal_title：Hearing research

authors： Fakhiri J,Landegger LD,Grimm D

更新日期：2020-10-15 00:00:00

abstract：:We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...

journal_title：Hearing research

authors： Chao TK,Burgess BJ,Eddington DK,Nadol JB Jr

更新日期：2002-12-01 00:00:00

abstract：:This study investigated the relation between the intelligibility of conversational and clear speech produced by older and younger adults and (a) the acoustic profile of their speech (b) communication effectiveness. Speech samples from 30 talkers from the elderLUCID corpus were used: 10 young adults (YA), 10 older adul...

journal_title：Hearing research

authors： Hazan V,Tuomainen O,Tu L,Kim J,Davis C,Brungart D,Sheffield B

更新日期：2018-11-01 00:00:00

abstract：:When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses record...

journal_title：Hearing research

authors： Waring MD,Ponton CW,Don M

更新日期：1999-04-01 00:00:00

abstract：:The superior colliculus (SC) is critical for directing accurate head and eye movements to visual and acoustic targets. In visual cortex, areas involved in orienting of the head and eyes to a visual stimulus have direct projections to the SC. In auditory cortex of the cat, four areas have been identified to be critical...

journal_title：Hearing research

authors： Chabot N,Mellott JG,Hall AJ,Tichenoff EL,Lomber SG

更新日期：2013-06-01 00:00:00

abstract：:Effects of stimulus level on discrimination of one stimulation site from another were examined in 15 human subjects with Nucleus-22 cochlear implant systems. Bipolar stimulation was used in all cases with electrodes in the bipolar pair separated by 1.5 mm (center to center). Subjects were first tested at a medium loud...

journal_title：Hearing research

authors： Pfingst BE,Holloway LA,Zwolan TA,Collins LM

更新日期：1999-08-01 00:00:00

abstract：:Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...

journal_title：Hearing research

authors： Zhang Q,Lan L,Shi W,Yu L,Xie LY,Xiong F,Zhao C,Li N,Yin Z,Zong L,Guan J,Wang D,Sun W,Wang Q

更新日期：2016-05-01 00:00:00

abstract：:Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit ...

journal_title：Hearing research

authors： Henry KS,Kale S,Scheidt RE,Heinz MG

更新日期：2011-10-01 00:00:00

abstract：:Biochemical and pharmacological evidence support a role for nitric oxide (NO) and glutathione (GSH) in the cochlea. GSH combines with NO in tissue to form nitrosoglutathione (GSNO) that can act as a storage form for GSH and NO. Therefore, we tested GSNO on sound-evoked responses of the cochlea (cochlear microphonic, C...

journal_title：Hearing research

authors： Nenov AP,Skellett RA,Fallon M,Bobbin RP

更新日期：1997-08-01 00:00:00

abstract：:The current distribution of bipolar electrodes implanted into the scala tympani of the cat cochlea was investigated using a two-electrode masking technique. Two electrode masking is a non-invasive technique which requires two electrically independent electrodes and relies upon the forward masking of the electrically e...

journal_title：Hearing research

authors： O'Leary SJ,Black RC,Clark GM

更新日期：1985-06-01 00:00:00

abstract：:Membranous vestibular labyrinths from the oyster toadfish, Opsanus tau, were fixed, dissected from the animal, stained, and embedded in rectangular blocks of clear histological resin. Photomicrographs of complete embedded labyrinths were taken from six orthogonal directions and used to construct three-dimensional (3D)...

journal_title：Hearing research

authors： Ghanem TA,Rabbitt RD,Tresco PA

更新日期：1998-10-01 00:00:00

abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...

journal_title：Hearing research

authors： Bibikov NG,Nizamov SV

更新日期：1996-11-01 00:00:00

abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...

journal_title：Hearing research

authors： Minoda R,Izumikawa M,Kawamoto K,Zhang H,Raphael Y

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Pitch perception of complex tones relies on place or temporal fine structure-based mechanisms from resolved harmonics and the temporal envelope of unresolved harmonics. Combining this information is essential for speech-in-noise performance, as it allows segregation of a target speaker from background noise....

journal_title：Hearing research

authors： Bonnard D,Schwalje A,Gantz B,Choi I

更新日期：2018-09-01 00:00:00

abstract：:Compound action potentials (AP) were recorded under various stimulus conditions in 31 guinea pigs. Stimulus attenuation, decrease of inter-stimulus interval, increase of the level of a continuous wide-band noise maker, and lowering the animal's temperature all resulted in a drop of the AP amplitude and an increase in ...

journal_title：Hearing research

authors： Prijs VF,Eggermont JJ

更新日期：1981-03-01 00:00:00

abstract：:Interactions between the statoacoustic ganglion and sensory vestibular epithelia have been investigated using different methods of organ and tissue cultures taken from mouse embryos on gestation day 13. Ultrastructural and biochemical observations of the degree of maturation of vestibular sensory cells and ganglion ne...

journal_title：Hearing research

authors： Raymond J

更新日期：1987-01-01 00:00:00

abstract：:Two methods were used to extract frequency specific information from the gross d.c. cochlear potential, the summating potential (SP). The first approach was to derive SP tuning curves using a two-tone simultaneous masking procedure; the second to obtain SP iso-response functions. The influence of various parameter cha...

journal_title：Hearing research

authors： Cheatham MA,Dallos P

更新日期：1984-11-01 00:00:00

abstract：:The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...

journal_title：Hearing research

authors： Ota Y,Dolan DF

更新日期：2000-10-01 00:00:00

abstract：:The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization; (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the ...

journal_title：Hearing research

authors： Lomber SG,Malhotra S,Hall AJ

更新日期：2007-07-01 00:00:00

abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...

journal_title：Hearing research

authors： Parham K,Sohal M,Petremann M,Romanet C,Broussy A,Tran Van Ba C,Dyhrfjeld-Johnsen J

更新日期：2019-01-01 00:00:00

abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...

journal_title：Hearing research

authors： van Emst MG,Klis SF,Smoorenburg GF

更新日期：1995-08-01 00:00:00

abstract：:Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...

journal_title：Hearing research

authors： Kong WJ,Ren T,Nuttall AL

更新日期：1996-09-15 00:00:00

abstract：:A simple model for the acoustic enhancement of electrically evoked otoacoustic emissions (EEOEs) is presented in this paper. The model is based on the assumption that the enhancement is a result of the local interaction between the electrical current spreading in the scala media and the basilar membrane (BM) response ...

journal_title：Hearing research

authors： Xue S,Mountain DC,Hubbard AE

更新日期：1995-11-01 00:00:00

abstract：:Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of th...

journal_title：Hearing research

authors： Nuttall AL,Fridberger A

更新日期：2012-11-01 00:00:00

abstract：:Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...

journal_title：Hearing research

authors： Van Trump WJ,Coombs S,Duncan K,McHenry MJ

更新日期：2010-03-01 00:00:00

abstract：:One objective electrophysiological test for deafness involves presenting a brief acoustic stimulus to a subject and measuring the electrical activity evoked in the muscle located just behind the ear (the post-auricular muscle or PAM). Although this electrical response has been known for many years, it has been ignored...

journal_title：Hearing research

authors： O'Beirne GA,Patuzzi RB

更新日期：1999-12-01 00:00:00

abstract：:The ability of auditory-nerve (AN) fibers to encode modulation frequencies, as characterized by temporal modulation transfer functions (TMTFs), generally shows a low-pass shape with a cut-off frequency that increases with fiber characteristic frequency (CF). Because AN-fiber bandwidth increases with CF, this result ha...

journal_title：Hearing research

authors： Kale S,Heinz MG

更新日期：2012-04-01 00:00:00

abstract：:At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduct...

journal_title：Hearing research

authors： Katz E,Verbitsky M,Rothlin CV,Vetter DE,Heinemann SF,Elgoyhen AB

更新日期：2000-03-01 00:00:00

abstract：:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...

journal_title：Hearing research

authors： Avallone B,Porritiello M,Esposito D,Mutone R,Balsamo G,Marmo F

更新日期：2003-04-01 00:00:00

abstract：:A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and ...

journal_title：Hearing research

authors： Rybak LP,Whitworth C

更新日期：1987-01-01 00:00:00