Abstract：
:At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduction in basilar membrane motion, altering auditory nerve fiber activity and reducing the dynamic range of hearing. The alpha9 nicotinic acetylcholine receptor (nAChR) subunit mediates synaptic transmission between cholinergic olivocochlear fibers and OHCs. Given that Ca(2+) is a key player at this inhibitory synapse, we evaluated the permeability to Ca(2+) of the recombinant alpha9 receptor expressed in Xenopus laevis oocytes and the modulation of its activity by extracellular Ca(2+). Our results show that the alpha9 receptor is highly permeable to Ca(2+) and that this cation potently blocks monovalent currents through this channel (IC(50)=100 microM, at -70 mV) in a voltage-dependent manner. At a Ca(2+) concentration similar to that found in the perilymph bathing the base of the OHCs, approximately 90% of the Na(+) current through the alpha9 receptor is blocked, suggesting that one of the main functions of this channel could be to provide a pathway for Ca(2+) influx.
journal_name
Hear Resjournal_title
Hearing researchauthors
Katz E,Verbitsky M,Rothlin CV,Vetter DE,Heinemann SF,Elgoyhen ABdoi
10.1016/s0378-5955(99)00214-2keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
117-28issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595599002142journal_volume
141pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Masking and binaural masking-level differences (BMLDs) were measured using short 400 and 800 Hz test tones masked by uniform masking noise in both pre- and post-masking conditions. The BMLD shows the same dependence on the temporal position of the test signal as masking itself. Additional data produced with interrupte...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90076-5
更新日期：1984-03-01 00:00:00
abstract：:The effect of interaural time differences (ITDs) on stream segregation for successive tone bursts was investigated. Obligatory stream segregation was inferred from the threshold for detecting a rhythmic irregularity in an otherwise isochronous sequence of interleaved "A" and "B" tones (task 1). Subjective stream segre...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.06.006
更新日期：2012-09-01 00:00:00
abstract：:Furosemide is a loop diuretic which is ototoxic. Investigations have shown the stria vascularis to be the target tissue of this ototoxic drug. The purpose of the present study was to investigate the effects of furosemide on the stria vascularis in chinchillas, in controls and in animals pretreated with the above organ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90104-u
更新日期：1992-04-01 00:00:00
abstract：:Progress in drug delivery to the ear has been achieved over the last few years. This review illustrates the main mechanisms of controlled drug release and the resulting geometry- and size-dependent release kinetics. The potency, physicochemical properties, and stability of the drug molecules are key parameters for des...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2018.03.006
更新日期：2018-10-01 00:00:00
abstract：:In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.12.023
更新日期：2011-03-01 00:00:00
abstract：:There is increasing evidence that humans and other nonhuman mammals are sensitive to the statistical structure of auditory input. Indeed, neural sensitivity to statistical regularities seems to be a fundamental biological property underlying auditory learning. In the case of speech, statistical regularities play a cru...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2013.08.018
更新日期：2014-02-01 00:00:00
abstract：:Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers -- one equal in frequency to the signal and another an octave below the signal. The ratio of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.10.006
更新日期：2005-03-01 00:00:00
abstract：:The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked poten...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107975
更新日期：2021-01-01 00:00:00
abstract：:Crossmodal plasticity takes place following sensory loss, such that areas that normally process the missing modality are reorganized to provide compensatory function in the remaining sensory systems. For example, congenitally deaf cats outperform normal hearing animals on localization of visual stimuli presented in th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.06.003
更新日期：2017-01-01 00:00:00
abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00151-1
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVE:Molecular analysis using archival human inner ear specimens is challenging because of the anatomical complexity, long-term fixation, and decalcification. However, this method may provide great benefit for elucidation of otological diseases. Here, we extracted mRNA for RT-PCR from tissues dissected from archiv...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.04.008
更新日期：2013-08-01 00:00:00
abstract：:New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...
journal_title：Hearing research
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:The etiology of an incidentally discovered temporary threshold shift observed in an experimental animal (Harley guinea pig) is discussed with its potential implications for auditory research. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90041-4
更新日期：1987-01-01 00:00:00
abstract：:Previous investigations have shown that a subset of inferior colliculus neurons, which have been designated type O units, respond selectively to isolated features of the cat's head-related transfer functions (HRTFs: the directional transformation of a free-field sound as it propagates from the head to the eardrum). Ba...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.01.008
更新日期：2008-04-01 00:00:00
abstract：:The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.002
更新日期：2009-11-01 00:00:00
abstract：:Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90221-1
更新日期：1984-07-01 00:00:00
abstract：:The ear of the goldfish (Carassius auratus) contains three otolithic endorgans: the saccule, lagena, and utricle. The saccule has an auditory function in most teleost fishes for whom data are available, and there is evidence that the lagena is also an auditory endorgan in the goldfish. This study was conducted to comp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00207-5
更新日期：2000-03-01 00:00:00
abstract：:A number of studies have shown that the ear can be protected from sound over-exposure, either by activating the cochlear efferent system, or by sound 'conditioning' in which the role of the efferent system is less certain. To study more definitively the molecular basis of deliberately induced cochlear protection from ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00265-9
更新日期：2001-06-01 00:00:00
abstract：:A model was developed to simulate acoustically the effects of excitation spread in cochlear implants (CI). Based on neurophysiologic data, the proposed model simulates the electrical-current decay rate associated with broad and narrow types of excitation, such as those produced by monopolar and bipolar electrode confi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.04.012
更新日期：2008-07-01 00:00:00
abstract：:In the cochlea, outer hair cells (OHCs) and Deiters' cells most likely contribute to the generation of active cochlear mechanics. The presence of ATP receptors on these cells indicates that endogenous ATP may have a role in cochlear mechanics. To explore this possibility, the effects of ATP antagonists were studied bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00093-2
更新日期：1997-09-01 00:00:00
abstract：:A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00078-6
更新日期：1997-08-01 00:00:00
abstract：:Sound-induced displacement responses in the plane of the organ of Corti were studied in the apical turn in the isolated temporal-bone preparation of the guinea-pig cochlea. Swept sinusoidal sound stimuli (100-500 Hz) were delivered closed-field to the external auditory meatus. The surface of the organ of Corti was con...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00002-l
更新日期：1995-03-01 00:00:00
abstract：:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00096-0
更新日期：2003-05-01 00:00:00
abstract：:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00378-1
更新日期：2001-12-01 00:00:00
abstract：:In these experiments the development of summating potential (SP) responses in gerbils from neonates to adults was followed. Special recording techniques were used to eliminate maturational effects associated with the middle ear so that developmental changes in cochlear physiology were isolated for study. Results indic...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90011-5
更新日期：1985-05-01 00:00:00
abstract：:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00050-7
更新日期：1999-07-01 00:00:00
abstract：:In a wide variety of mammals, the rim of the tympanic membrane (annulus fibrosus) has an array of contractile elements, either smooth muscle [Henson and Henson, J. Assoc. Res. Otolaryngol. 1 (2000) 25-32] or myofibroblasts [Kuijpers et al., Hear. Res. 128 (1999) 80-88]. These elements are anchored peripherally to the ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00416-6
更新日期：2002-02-01 00:00:00
abstract：:A large sample of threshold tuning curves of single units from various levels of the auditory pathway was used in order to examine the relationship between best frequency and a measure of sharpness of tuning. This measure is simply the tuning curve bandwidth at 20 dB above threshold on a square-root scale of frequency...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90070-9
更新日期：1983-09-01 00:00:00
abstract：:Human subjects performed in several behavioral conditions requiring, or not requiring, selective attention to visual stimuli. Specifically, the attentional task was to recognize strings of digits that had been presented visually. A nonlinear version of the stimulus-frequency otoacoustic emission (SFOAE), called the nS...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.03.013
更新日期：2014-06-01 00:00:00
