Morphometric changes in the cochlear nucleus in patients who had undergone cochlear implantation for bilateral profound deafness.

Abstract:

:We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes of the ventral cochlear nucleus (VCN) and dorsal cochlear nucleus (DCN), and the maximal cross-sectional area and densities of cell bodies in the anterior ventral cochlear nucleus (AVCN) were measured bilaterally by light microscopy assisted by the Neurolucida 2000 image analysis system. In addition, the density of synapses on cells of the AVCN were estimated using immunostaining for the synaptosome-associated protein (SNAP-25) by light microscopy. There was no significant difference in volumes of VCN and DCN, maximal cross-sectional area and density of cell bodies of the AVCN, and SNAP-25 immunostaining between the cochlear nucleus ipsilateral and contralateral to cochlear implantation. In addition, there was no significant correlation between these morphometric parameters and clinical performance. Peripheral deafness seems to reduce the size of neurons in the AVCN in that the maximum diameter of cell bodies was greater in the ear with better hearing preoperatively (chi-square test P<0.05). However, electrical stimulation provided by the cochlear implantation did not alter these morphometric changes in adult cochlear implant patients.

journal_name

Hear Res

journal_title

Hearing research

authors

Chao TK,Burgess BJ,Eddington DK,Nadol JB Jr

doi

10.1016/s0378-5955(02)00694-9

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

196-205

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378595502006949

journal_volume

174

pub_type

杂志文章
  • Examining the role of frequency specificity in the enhancement and suppression of human cortical activity by auditory selective attention.

    abstract::This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.08.007

    authors: Paltoglou AE,Sumner CJ,Hall DA

    更新日期:2009-11-01 00:00:00

  • Masked thresholds of auditory midbrain neurons in the frog Rana ridibunda.

    abstract::Single-unit recordings from neurons in the torus semicircularis of Rana ridibunda were analyzed to determine the degree to which these neurons can detect acoustic stimuli superimposed on continuous, broad-band noise. In the first series of trials the stimuli were tone pulses 25 ms long, 5 dB above threshold, and at th...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90117-7

    authors: Joermann G

    更新日期:1988-09-15 00:00:00

  • In search of the best stimulus: an optimization procedure for finding efficient stimuli in the cat auditory cortex.

    abstract::Units in the auditory cortex of cats respond to a large variety of stimuli: pure tones, AM- and FM-modulated signals, clicks, wideband noise, natural sounds, and more. However, no single family of sounds was found to be optimal (in the sense that oriented lines are optimal in the visual cortex). The search for optimal...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90222-4

    authors: Nelken I,Prut Y,Vaadia E,Abeles M

    更新日期:1994-01-01 00:00:00

  • Fetal tectum grafted as a cell suspension into the adult rat inferior colliculus.

    abstract::The known structural and functional features of the inferior colliculus provided an advantageous substrate for examining the outcome of neural transplantation. In the present study, tissue from the midbrain tectum of Sprague-Dawley rat fetuses was removed at 15, 16 and 19 days of gestation (E15, E16 and E19), incubate...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90123-7

    authors: Zrull MC,Coleman JR

    更新日期:1990-05-01 00:00:00

  • Subcellular changes in the endolymphatic sac after administration of hyperosmolar substances.

    abstract::The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90045-7

    authors: Erwall C,Jansson B,Friberg U,Rask-Andersen H

    更新日期:1988-09-01 00:00:00

  • Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus.

    abstract::High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2012.11.016

    authors: Chen GD,Stolzberg D,Lobarinas E,Sun W,Ding D,Salvi R

    更新日期:2013-01-01 00:00:00

  • Noise dosimetry for tactical environments.

    abstract::Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2016.11.008

    authors: Smalt CJ,Lacirignola J,Davis SK,Calamia PT,Collins PP

    更新日期:2017-06-01 00:00:00

  • Automatic monitoring of mechano-electrical transduction in the guinea pig cochlea.

    abstract::We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00125-7

    authors: Patuzzi R,Moleirinho A

    更新日期:1998-11-01 00:00:00

  • Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis.

    abstract::Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(01)00252-0

    authors: Takeuchi S,Ando M,Sato T,Kakigi A

    更新日期:2001-05-01 00:00:00

  • The connexin 30.3 of zebrafish homologue of human connexin 26 may play similar role in the inner ear.

    abstract::The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2014.04.010

    authors: Chang-Chien J,Yen YC,Chien KH,Li SY,Hsu TC,Yang JJ

    更新日期:2014-07-01 00:00:00

  • Age-related shifts in distortion product otoacoustic emissions peak-ratios and amplitude modulation spectra.

    abstract::Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2015.07.017

    authors: Lai J,Bartlett EL

    更新日期:2015-09-01 00:00:00

  • Effects of waveform shape on human sensitivity to electrical stimulation of the inner ear.

    abstract::Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electro...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.08.006

    authors: van Wieringen A,Carlyon RP,Laneau J,Wouters J

    更新日期:2005-02-01 00:00:00

  • WITHDRAWN: A critical need in hearing.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.12.012

    authors: Hudspeth AJ,Martin P

    更新日期:2010-01-30 00:00:00

  • Conserved mechanisms of vocalization coding in mammalian and songbird auditory midbrain.

    abstract::The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.05.005

    authors: Woolley SM,Portfors CV

    更新日期:2013-11-01 00:00:00

  • Narrow-band ripple glide direction discrimination and its relationship to frequency selectivity estimated using psychophysical tuning curves.

    abstract::The highest spectral ripple density at which the discrimination of ripple glide direction was possible (STRtdir task) was assessed for one-octave wide (narrowband) stimuli with center frequencies of 500, 1000, 2000, and 4000 Hz and for a broadband stimulus. A pink noise lowpass filtered at the lower edge frequency of ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.107910

    authors: Narne VK,Jain S,Sharma C,Baer T,Moore BCJ

    更新日期:2020-04-01 00:00:00

  • Identification of the lateral position of a virtual object based on echoes by humans.

    abstract::Echolocation offers a promising approach to improve the quality of life of people with blindness although little is known about the factors influencing object localisation using a 'searching' strategy. In this paper, we describe a series of experiments using sighted and blind human listeners and a 'virtual auditory sp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.03.005

    authors: Rowan D,Papadopoulos T,Edwards D,Holmes H,Hollingdale A,Evans L,Allen R

    更新日期:2013-06-01 00:00:00

  • Growth of distortion product otoacoustic emissions with primary-tone level in humans.

    abstract::This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90016-t

    authors: Popelka GR,Osterhammel PA,Nielsen LH,Rasmussen AN

    更新日期:1993-12-01 00:00:00

  • Maturation of middle ear transmission in children.

    abstract::The goal of the current study was to characterize the normative features of wideband acoustic immittance in children for describing the functional maturation of the middle ear in 5 to 12-year-old children. Absorbance and group delay were measured in adults and three groups of children, 5-6, 7-9 and 10-12-year-olds, in...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2016.10.029

    authors: Mishra SK,Dinger Z,Renken L

    更新日期:2017-02-01 00:00:00

  • Direct bone conduction stimulation: Ipsilateral effect of different transducer attachments in active transcutaneous devices.

    abstract::Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the co...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.01.007

    authors: Rigato C,Reinfeldt S,Håkansson B,Fredén Jansson KJ,Renvall E,Eeg-Olofsson M

    更新日期:2018-04-01 00:00:00

  • On the prediction of sweep rate and directional selectivity for FM sounds from two-tone interactions in the inferior colliculus.

    abstract::Two-tone stimuli have traditionally been used to reveal regions of inhibition in auditory spectral receptive fields, particularly for neurons with low spontaneous rates. These techniques reveal how different frequencies excite or suppress the response to an excitatory frequency of a cell, but have often been assessed ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2005.07.005

    authors: Brimijoin WO,O'Neill WE

    更新日期:2005-12-01 00:00:00

  • Effect of stimulus level on the temporal response properties of the auditory nerve in cochlear implants.

    abstract::Electrically evoked compound action potentials (ECAPs) have been used to examine temporal response patterns of the auditory nerve in cochlear implant (CI) recipients. ECAP responses to individual pulses in a pulse train vary across stimulation rates for individual CI users. For very slow rates, auditory neurons have a...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.06.004

    authors: Hughes ML,Laurello SA

    更新日期:2017-08-01 00:00:00

  • Detection efficiency of auditory steady state evoked by modulated noise.

    abstract:AIM:This study aimed to investigate the efficiency of Magnitude Squared Coherence (MSC) and Spectral F test (SFT) for the detection of auditory steady state responses (ASSR) obtained by amplitude-modulated noises. MATERIAL AND METHODS:Twenty individuals (12 women) without any history of neurological or audiological di...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2016.05.017

    authors: Santos TS,Silva JJ,Lins OG,Melges DB,Tierra-Criollo CJ

    更新日期:2016-09-01 00:00:00

  • Potassium channel gene expression in the rat cochlear nucleus.

    abstract::Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2007.01.024

    authors: Friedland DR,Eernisse R,Popper P

    更新日期:2007-06-01 00:00:00

  • Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea.

    abstract::Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.02.017

    authors: Nishio SY,Takumi Y,Usami SI

    更新日期:2017-05-01 00:00:00

  • Effects of forskolin and 1,9-dideoxy-forskolin on cochlear potentials.

    abstract::Endocochlear potential (EP) and cochlear microphonics (CM) were recorded during the perilymphatic perfusion with forskolin known as an adenylate cyclase stimulant. Forskolin produced a reversible EP elevation in a dose-dependent manner. Perfusion with 1,9-dideoxy-forskolin, an analogue of forskolin that does not stimu...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90192-r

    authors: Doi K,Mori N,Matsunaga T

    更新日期:1990-04-01 00:00:00

  • Cochlear-implant spatial selectivity with monopolar, bipolar and tripolar stimulation.

    abstract::Sharp spatial selectivity is critical to auditory performance, particularly in pitch-related tasks. Most contemporary cochlear implants have employed monopolar stimulation that produces broad electric fields, which presumably contribute to poor pitch and pitch-related performance by implant users. Bipolar or tripolar ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2011.11.005

    authors: Zhu Z,Tang Q,Zeng FG,Guan T,Ye D

    更新日期:2012-01-01 00:00:00

  • Perception of spectrally and temporally complex sounds by the goldfish (Carassius auratus).

    abstract::Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(95)00132-8

    authors: Fay RR

    更新日期:1995-09-01 00:00:00

  • Two-tone suppression, excitation and the after effect in rate responses in auditory nerve fibres in the cat.

    abstract::Responses were recorded from single, auditory nerve fibres in the anaesthetized cat. Acoustic stimuli consisted of two tones, one of which was at characteristic frequency (CF), the other (the suppressor) was at considerably lower frequency. Tones were presented in simultaneous and sequential configurations. For simult...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(92)90167-l

    authors: Hill KG,Geisler CD

    更新日期:1992-12-01 00:00:00

  • Expression of osteopontin by exudate macrophages in inflammatory tissues of the middle ear: a possible association with development of tympanosclerosis.

    abstract::Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00260-4

    authors: Makiishi-Shimobayashi C,Tsujimura T,Sugihara A,Iwasaki T,Yamada N,Terada N,Sakagami M

    更新日期:2001-03-01 00:00:00

  • Tone-induced stereocilia lesions as a function of exposure level and duration in the hamster cochlea.

    abstract::The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at th...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(92)90022-f

    authors: Kaltenbach JA,Schmidt RN,Kaplan CR

    更新日期:1992-07-01 00:00:00