Abstract：
:Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned into an expression vector and the nucleotide sequence was analyzed to confirm the expression of mRNA encoding MR in the cochlea. We then synthesized digoxigenin-labeled riboprobes with this cloned DNA template and examined the localization of MR mRNA in the cochlea by in situ hybridization. The amino acid sequence of MR cDNA expressed in the cochlea was identical to that of the MR first cloned in the rat hippocampus. In situ hybridization showed the expression of MR mRNA in marginal cells of the stria vascularis, suggesting that aldosterone may regulate microhomeostasis of the endolymph, presumably by modulating Na, K-ATPase activity. Intense MR signal was also identified in spiral ganglion cells, the function of which remains to be determined.
journal_name
Hear Resjournal_title
Hearing researchauthors
Furuta H,Mori N,Sato C,Hoshikawa H,Sakai S,Iwakura S,Doi Kdoi
10.1016/0378-5955(94)90023-xsubject
Has Abstractpub_date
1994-08-01 00:00:00pages
175-80issue
2eissn
0378-5955issn
1878-5891pii
0378-5955(94)90023-Xjournal_volume
78pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：BACKGROUND:Recently, in vitro and in vivo models have identified that microRNAs (miRNAs), which are extensively expressed in the inner ear, play important roles in inner ear development and function. However, the function of miRNA in vertebrate tissue is not well understood. RESULTS:The current study used an in vitro ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.02.005
更新日期：2012-04-01 00:00:00
abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00339-2
更新日期：2001-10-01 00:00:00
abstract：:A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00051-5
更新日期：1995-06-01 00:00:00
abstract：:The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2009.12.028
更新日期：2011-03-01 00:00:00
abstract：:Measurements were made of inner hair cell receptor potentials and basilar membrane motion in the 17-21 kHz region of the guinea pig cochlea. The latter were made using the Mossbauer technique. Isoamplitude curves at 0.9 mV d.c. receptor potential were compared with isovelocity curves at 0.04 mm/s and the corresponding...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90019-9
更新日期：1983-04-01 00:00:00
abstract：:This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2011.05.001
更新日期：2011-11-01 00:00:00
abstract：:Anatomically correct turtle utricle geometry was incorporated into two finite element models. The geometrically accurate model included appropriately shaped macular surface and otoconial layer, compact gel and column filament (or shear) layer thicknesses and thickness distributions. The first model included a shear la...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.10.010
更新日期：2014-12-01 00:00:00
abstract：:Several studies have been performed in which both the time-dependent and steady state output of cells in the dorsal nucleus of the lateral lemniscus (DNLL) have been measured in response to binaural sound stimulation. In this paper, a mathematical and computational model for the steady state output of DNLL cells is fo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00096-9
更新日期：1999-10-01 00:00:00
abstract：:Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.001
更新日期：2010-03-01 00:00:00
abstract：:Progress in drug delivery to the ear has been achieved over the last few years. This review illustrates the main mechanisms of controlled drug release and the resulting geometry- and size-dependent release kinetics. The potency, physicochemical properties, and stability of the drug molecules are key parameters for des...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2018.03.006
更新日期：2018-10-01 00:00:00
abstract：:High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.021
更新日期：2017-04-01 00:00:00
abstract：:Previous studies have shown a reduction of the ototoxicity of furosemide in chinchillas pretreated with organic acid transport inhibitors. The current studies were designed to investigate whether such a protective effect could be observed in chinchillas receiving ethacrynic acid. Chinchillas weighing 400-600 g were in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90142-c
更新日期：1990-06-01 00:00:00
abstract：:New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...
journal_title：Hearing research
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Pairs of single units were recorded simultaneously from the same microelectrode in the medial geniculate body (MGB) of nitrous oxide anaesthetized cats. Crosscorrelation histograms of each spike train pairs were computed and distributed in five main classes, interpreted in terms of functional interaction between neigh...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90093-1
更新日期：1987-01-01 00:00:00
abstract：:The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physio...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2018.10.001
更新日期：2019-05-01 00:00:00
abstract：:Frequency discrimination thresholds were measured from five chinchillas for harmonic tone complexes having a fundamental frequency of 250 Hz. Stimuli consisted of the fundamental frequency and the second through 10th harmonics with individual components added in either cosine phase or random phase. In general, thresho...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00171-4
更新日期：2000-11-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90052-1
更新日期：1982-02-01 00:00:00
abstract：:Functional magnetic resonance imaging is a noninvasive and nonradioactive method for the detection of focal brain activity. In the present study the auditory cortex was investigated in nine normal subjects who were binaurally stimulated using pulsed sine tones of 500 Hz and 4000 Hz. The BOLD (blood oxygenation level d...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00139-7
更新日期：1998-12-01 00:00:00
abstract：:This study examined how speech babble noise differentially affected the auditory P3 responses and the associated neural oscillatory activities for consonant and vowel discrimination in relation to segmental- and sentence-level speech perception in noise. The data were collected from 16 normal-hearing participants in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.04.009
更新日期：2017-07-01 00:00:00
abstract：:The primary goal of most cochlear implant procedures is to improve a patient's ability to discriminate speech. To accomplish this, cochlear implants are programmed so as to maximize speech understanding. However, programming a cochlear implant can be an iterative, labor-intensive process that takes place over months. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.11.007
更新日期：2014-03-01 00:00:00
abstract：:Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.07.017
更新日期：2015-09-01 00:00:00
abstract：:Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00132-8
更新日期：1995-09-01 00:00:00
abstract：:For the elevation and front-versus-back hemifield of a sound source to be accurately determined, the sound must contain a broad range of frequencies. Experiment 1 of this study examined the spectral integration time of the auditory localisation system by measuring the accuracy with which frequency-modulated (FM) tones...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.08.006
更新日期：2008-04-01 00:00:00
abstract：:Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.09.005
更新日期：2007-12-01 00:00:00
abstract：:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00119-5
更新日期：1995-09-01 00:00:00
abstract：:Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.006
更新日期：2010-03-01 00:00:00
abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00095-l
更新日期：1995-08-01 00:00:00
abstract：:In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2005.02.012
更新日期：2005-08-01 00:00:00
abstract：:Auditory thresholds were measured for 18 ears from 13 rhesus monkeys using a simple reaction-time procedure. The threshold contour was a smooth W-shaped function with rises at the extreme frequencies and around 4 kHz and was comparable in shape with previously reported thresholds for this animal. Standard deviations a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(78)90008-4
更新日期：1978-10-01 00:00:00
