Minimal sex differences in gene expression in the rat superior olivary complex.

abstract：:Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage induced by a broad range of cisplatin treatment concentrations was examined. Paradoxically, it was found that hair cell loss was greate...

journal_title：Hearing research

authors： Ding D,He J,Allman BL,Yu D,Jiang H,Seigel GM,Salvi RJ

更新日期：2011-12-01 00:00:00

abstract：:The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...

journal_title：Hearing research

authors： Luo F,Wang Q,Farid N,Liu X,Yan J

更新日期：2009-11-01 00:00:00

abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...

journal_title：Hearing research

authors： Siegel RA,Colburn HS

更新日期：1983-08-01 00:00:00

abstract：:Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...

journal_title：Hearing research

authors： Mockett BG,Bo X,Housley GD,Thorne PR,Burnstock G

更新日期：1995-04-01 00:00:00

abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...

journal_title：Hearing research

authors： Walters BJ,Cox BC

更新日期：2019-05-01 00:00:00

abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...

journal_title：Hearing research

authors： Orduña I,Mercado E 3rd,Gluck MA,Merzenich MM

更新日期：2001-10-01 00:00:00

abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...

journal_title：Hearing research

authors： Drayton M,Noben-Trauth K

更新日期：2006-02-01 00:00:00

abstract：:The field L complex is thought to be the highest auditory centre and the input in the song vocal nuclei. Different anatomical and functional subdivisions have been described in field L. Auditory neurons of field L are well activated by natural sounds and especially by species-specific sounds. A complex sound coding ap...

journal_title：Hearing research

authors： Cousillas H,Leppelsack HJ,Leppelsack E,Richard JP,Mathelier M,Hausberger M

更新日期：2005-09-01 00:00:00

abstract：:The relation between hearing loss and loss of hair cells after prolonged exposure to a simulated industrial noise environment was determined in normotensive albino rats. Hearing loss was assessed behaviorally by a conditioned suppression technique and electrophysiologically by auditory brainstem response to pulses of ...

journal_title：Hearing research

authors： Borg E

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:This paper introduces a new method to calculate relative risks of elevated hearing thresholds, at various ages and frequencies, between a study population and ISO1999:2003: Annex A Screened, Annex B Unscreened and ISO1999 Section 5.3 adjustment for noise exposure using Annex A Screened data. We demonstrate th...

journal_title：Hearing research

authors： Guest M,Boggess M,Attia J,SHOAMP study team and Scientific Advisory Committee.

更新日期：2012-03-01 00:00:00

abstract：:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...

journal_title：Hearing research

authors： Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann R

更新日期：1997-04-01 00:00:00

abstract：:Delayed acoustic waves have been measured in the sealed ear canal in response to click and tone-burst stimuli. The response shows compressive nonlinearity, evidence for 'active' processing, and frequency tuning. At low sound levels group and phase delays correspond, and represent about 15 waves delay for the mid-frequ...

journal_title：Hearing research

authors： Wilson JP

更新日期：1980-06-01 00:00:00

abstract：:A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...

journal_title：Hearing research

authors： Adler HJ,Niemiec AJ,Moody DB,Raphael Y

更新日期：1995-06-01 00:00:00

abstract：:Light microscopy and immunohistochemical analyses of a freshly prepared human cochlea, removed at meningioma skull base surgery, were performed with particular emphasis on synaptophysin (SY) reactivity. Synaptophysin, a 38-kDa glycoprotein, is one of the most abundant integral membrane proteins of small presynaptic ve...

journal_title：Hearing research

authors： Khalifa SA,Friberg U,Illing RB,Rask-Andersen H

更新日期：2003-11-01 00:00:00

abstract：:Several studies have shown that treatment with various neurotrophins protects spiral ganglion cells (SGCs) from degeneration in hair-cell deprived cochleas. In most of these studies the neurotrophins are delivered by means of intracochlear delivery methods. Recently, other application methods that might be more suited...

journal_title：Hearing research

authors： Havenith S,Versnel H,Agterberg MJ,de Groot JC,Sedee RJ,Grolman W,Klis SF

更新日期：2011-02-01 00:00:00

abstract：:In a previous study, we have demonstrated the presence of two adenosine receptor (AR) subtypes, namely A1 and A3AR, in the chinchilla cochlea. One or both of these receptors couple to activation of antioxidant enzymes, with resulting decreases in lipid peroxidation. The chemotherapeutic agent, cisplatin, was shown to ...

journal_title：Hearing research

authors： Ford MS,Nie Z,Whitworth C,Rybak LP,Ramkumar V

更新日期：1997-09-01 00:00:00

abstract：:Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...

journal_title：Hearing research

authors： Malgrange B,Rigo JM,Coucke P,Thiry M,Hans G,Nguyen L,van de Water TR,Moonen G,Lefebvre PP

更新日期：2002-08-01 00:00:00

abstract：:Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...

journal_title：Hearing research

authors： Oghalai JS,Tran TD,Raphael RM,Nakagawa T,Brownell WE

更新日期：1999-09-01 00:00:00

abstract：:Kanamycin ototoxicity, combined with behavioral audiometry to evaluate threshold shifts, was used to destroy outer hair cells (OHCs) in the basal cochlea of the chincilla while leaving the inner hair cell (IHC) population largely intact. After survival times of four weeks to one year, transmission electron microscopy ...

journal_title：Hearing research

authors： Ryan AF,Woolf NK,Bone RC

更新日期：1980-12-01 00:00:00

abstract：:Several studies have compared the frequency selectivity of waves I and V of the auditory brainstem response (ABR) in humans, however little is known about the frequency selectivity of the middle latency response (MLR). Simultaneous recordings of ABRs and MLRs to 60 dB peSPL 2000-Hz probe tones were obtained in the pre...

journal_title：Hearing research

authors： Mackersie C,Down KE,Stapells DR

更新日期：1993-02-01 00:00:00

abstract：:Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure, suggesting roles in energy expenditure and heat ...

journal_title：Hearing research

authors： Kitahara T,Li HS,Balaban CD

更新日期：2004-10-01 00:00:00

abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...

journal_title：Hearing research

authors： Martini M,Rispoli G,Farinelli F,Fesce R,Rossi ML

更新日期：2004-09-01 00:00:00

abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...

journal_title：Hearing research

authors： Wang JA,Dong WJ,Chen JS

更新日期：1990-03-01 00:00:00

abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...

journal_title：Hearing research

authors： Curthoys IS,Vulovic V,Burgess AM,Sokolic L,Goonetilleke SC

更新日期：2016-01-01 00:00:00

abstract：:The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...

journal_title：Hearing research

authors： Firzlaff U,Schuller G

更新日期：2003-07-01 00:00:00

abstract：:Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...

journal_title：Hearing research

authors： Kong WJ,Ren T,Nuttall AL

更新日期：1996-09-15 00:00:00

abstract：:The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...

journal_title：Hearing research

authors： Wang X,Cheng YL,Yang DD,Si WJ,Jen PH,Yang CH,Chen QC

更新日期：2019-06-01 00:00:00

abstract：:In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...

journal_title：Hearing research

authors： Popper AN,Fay RR

更新日期：2011-03-01 00:00:00

abstract：:Harmonic complex tones are a particularly important class of sounds found in both speech and music. Although these sounds contain multiple frequency components, they are usually perceived as a coherent whole, with a pitch corresponding to the fundamental frequency (F0). However, when two or more harmonic sounds occur ...

journal_title：Hearing research

authors： Micheyl C,Oxenham AJ

更新日期：2010-07-01 00:00:00

abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...

journal_title：Hearing research

authors： Shi GZ,Gong LX,Xu XH,Nie WY,Lin Q,Qi YS

更新日期：2004-11-01 00:00:00