Relative risk of elevated hearing threshold compared to ISO1999 normative populations for Royal Australian Air Force male personnel.

Abstract:

OBJECTIVE:This paper introduces a new method to calculate relative risks of elevated hearing thresholds, at various ages and frequencies, between a study population and ISO1999:2003: Annex A Screened, Annex B Unscreened and ISO1999 Section 5.3 adjustment for noise exposure using Annex A Screened data. We demonstrate this method on a study population of male Royal Australian Air Force personnel. STUDY DESIGN:Using a retrospective cohort design, hearing thresholds were assessed in 583 F-111 aircraft maintenance personnel, 377 technical-trade comparisons and 492 non-technical comparisons using pure-tone audiometry. A quantile regression model was used determine whether an association exists between median hearing thresholds and F-111 maintenance, adjusting for possible confounders. The new method involves using quantile regression models with bootstrapped standard errors to estimate percentiles for the study population and thus determine the probability of a greater than 25 dB hearing threshold. This was done for the three ISO datasets as follows; for the ISO1999 Annex A screened population data the formula provided allows the calculation of these probabilities. ISO1999 Annex B unscreened population data only provides the values for the 10th, 50th and 90th percentiles at ages 30, 40, 50 and 60 only, therefore it was necessary to fit a curve to these values in order to estimate the probabilities. For ISO1999 Section 5.3 adjustment for noise exposure population we used the Annex A screened population data plus the formula. The probabilities were then divided to give the relative risks of a greater than 25 dB hearing threshold, at various ages and frequencies. RESULTS:While no difference was observed between the three groups, the model identified a number of significant confounders, namely tinnitus, smoking, diabetes and the use of anti-depressant medications. Relative risks were high at frequencies 2 kHz and less for the study population of all ages compared to ISO A screened data. The increased relative risks at 4 and 6 kHz give the appearance of a "noise notch" for ages 30 and 40 years. The comparison with the ISO B unscreened data are significantly less than one for frequencies above 2 kHz, particularly for young men and greater than one less than 2 kHz. The relative risks for the comparison to the ISO A screened data with ISO 5.3 adjustments, are highest for young men decreasing with age, with the highest relative risk are at frequencies less than 2 kHz. CONCLUSIONS:This paper demonstrates a new method for quantifying the probability of a clinically relevant hearing loss and the relative risk of the loss due to a risk factor. Prior to this, researchers were reduced to simplistic methods such as visual comparison of deciles which did not enable the estimation of risk. The new method can use all observed hearing thresholds per study participant, adjust for known confounding factors such age and gender, and calculate the relative risk of a clinically relevant increase in hearing threshold due to a risk factor of interest.

journal_name

Hear Res

journal_title

Hearing research

authors

Guest M,Boggess M,Attia J,SHOAMP study team and Scientific Advisory Committee.

doi

10.1016/j.heares.2012.01.007

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

65-76

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(12)00017-2

journal_volume

285

pub_type

杂志文章
  • Simulation of ILD sensitive neurons in the inferior colliculus of the barn owl.

    abstract::The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00102-6

    authors: Peddicord R

    更新日期:1998-09-01 00:00:00

  • Focal electrical stimulation of dorsal nucleus of the lateral lemniscus modulates auditory response properties of inferior collicular neurons in the albino mouse.

    abstract::The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2019.01.024

    authors: Wang X,Cheng YL,Yang DD,Si WJ,Jen PH,Yang CH,Chen QC

    更新日期:2019-06-01 00:00:00

  • Distribution of catestatin-like immunoreactivity in the human auditory system.

    abstract::Chromogranin A (CgA) belongs to the family of chromogranin peptides which are contained in large dense-core vesicles. The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catestatin is a recently c...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00223-5

    authors: Bitsche M,Mahata SK,Marksteiner J,Schrott-Fischer A

    更新日期:2003-10-01 00:00:00

  • Effects of spike discharge history on discharge probability and latency in frog basilar papilla units.

    abstract::Gaumond et al. [(1982) J. Neurophysiol. 48, 856-873] showed in the cat that a multiplicative-intensity model can generally account quite well for reduction of the probability of an auditory-nerve spike by another spike preceding it by 4 to 25 ms, and that for smaller separations there is also an increased latency of t...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90093-g

    authors: Ronken DA,Bosch WR,Molnar CE

    更新日期:1993-09-01 00:00:00

  • The effect of dorsal cochlear nucleus ablation on tinnitus in rats.

    abstract::A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.12.013

    authors: Brozoski TJ,Bauer CA

    更新日期:2005-08-01 00:00:00

  • A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.

    abstract::Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2007.09.005

    authors: Longo-Guess C,Gagnon LH,Bergstrom DE,Johnson KR

    更新日期:2007-12-01 00:00:00

  • Neural tuning characteristics of auditory primary afferents in the chicken embryo.

    abstract::Primary afferent activity was recorded from the cochlear ganglion in chicken embryos (Gallus domesticus) at 19 days of incubation (E19). The ganglion was accessed via the recessus scala tympani and impaled with glass micropipettes. Frequency tuning curves were obtained using a computerized threshold tracking procedure...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)00172-m

    authors: Jones SM,Jones TA

    更新日期:1995-02-01 00:00:00

  • Transganglionic transport of D-aspartate from cochlear nucleus to cochlea--a quantitative autoradiographic study.

    abstract::This study concerns the connections of the inner and outer hair cells and the different types of ganglion cells of the mammalian cochlea with the central nervous system by making use of their putative neurotransmitters. D-[3H]Aspartate (D-ASP), a putative marker for glutamatergic neurons, was injected into the cochlea...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(84)90029-7

    authors: Jones DR,Morest DK,Oliver DL,Potashner SJ

    更新日期:1984-09-01 00:00:00

  • The influence of postoperative tissue formation on sound transmission after stapes surgery.

    abstract::In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface. It was the hypothes...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.08.012

    authors: Sim JH,Chatzimichalis M,Huber AM

    更新日期:2010-05-01 00:00:00

  • Eye color as a risk factor for acquired sensorineural hearing loss: a review.

    abstract::Eye color may be an indicator of inner ear melanin content and has been associated with hearing loss. There is controversy as to whether eye color has an effect on acquired causes of sensorineural hearing loss. This review was conducted to analyze the literature evaluating the relationship between eye color and causes...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2014.12.002

    authors: Mujica-Mota MA,Schermbrucker J,Daniel SJ

    更新日期:2015-02-01 00:00:00

  • Comparison of frequency discrimination thresholds for complex and single tones in chinchillas.

    abstract::Frequency discrimination thresholds were measured from five chinchillas for harmonic tone complexes having a fundamental frequency of 250 Hz. Stimuli consisted of the fundamental frequency and the second through 10th harmonics with individual components added in either cosine phase or random phase. In general, thresho...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00171-4

    authors: Shofner WP

    更新日期:2000-11-01 00:00:00

  • Calcification processes in the chick otoconia and calcium binding proteins: patterns of tetracycline incorporation and calbindin-D28K distribution.

    abstract::In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00094-0

    authors: Balsamo G,Avallone B,Del Genio F,Trapani S,Marmo F

    更新日期:2000-10-01 00:00:00

  • Application of frequency modulated chirp stimuli for rapid and sensitive ABR measurements in the rat.

    abstract::Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2008.09.001

    authors: Spankovich C,Hood LJ,Wesley Grantham D,Polley DB

    更新日期:2008-11-01 00:00:00

  • Detection of auditory sinusoids of fixed and uncertain frequency by budgerigars (Melopsittacus undulatus) and zebra finches (Poephila guttata).

    abstract::Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90043-o

    authors: Okanoya K,Dooling RJ

    更新日期:1990-12-01 00:00:00

  • Morphology of the endolymphatic sac in the guinea pig after an acute endolymphatic hydrops.

    abstract::The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES's epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microinjection of 1.1 mul artificial endolymph into scala media of the cochlea, guinea pigs we...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.10.010

    authors: Valk WL,Wit HP,Segenhout JM,Dijk F,van der Want JJ,Albers FW

    更新日期:2005-04-01 00:00:00

  • The relative role of beats and combination tones in determining the shapes of masking patterns: II. Hearing-impaired listeners.

    abstract::Masking patterns were measured for hearing-impaired subjects with varying degrees of hearing loss. In one set of conditions, three subjects were tested using narrowband noise ('noise') and sinusoidal ('tone') maskers and narrowband noise signals. The maskers had centre frequencies of 0.25, 0.5, 1.0 and 4.0 kHz and lev...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00291-5

    authors: Alcántara JI,Moore BC

    更新日期:2002-03-01 00:00:00

  • WITHDRAWN: Membrane-based amplification in hearing.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.09.016

    authors: Brownell WE

    更新日期:2009-10-07 00:00:00

  • Basic properties of the sound-evoked post-auricular muscle response (PAMR).

    abstract::One objective electrophysiological test for deafness involves presenting a brief acoustic stimulus to a subject and measuring the electrical activity evoked in the muscle located just behind the ear (the post-auricular muscle or PAM). Although this electrical response has been known for many years, it has been ignored...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00159-8

    authors: O'Beirne GA,Patuzzi RB

    更新日期:1999-12-01 00:00:00

  • p27Kip1 down-regulation as achieved by two clinically feasible means did not induce proliferation of supporting cells in the rat neonatal cochlea in vivo.

    abstract::In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2018.12.002

    authors: Silva SA,Maass JC

    更新日期:2019-03-01 00:00:00

  • Coincidence detection in auditory neurons: a possible mechanism to enhance stimulus specificity in the grassfrog.

    abstract::It is still a matter of debate whether neurons in the higher central nervous system of anurans become progressively more sharply tuned to sounds that have a behavioral importance or that such coding is performed by (small) groups of neurons. The approach we have taken to investigate this matter comprises simultaneous ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90138-9

    authors: Eggermont JJ,Epping WJ

    更新日期:1987-01-01 00:00:00

  • Measurement of the mechanical compliance of the endolymphatic compartments in the guinea pig.

    abstract::During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. I...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00078-2

    authors: Wit HP,Warmerdam TJ,Albers FW

    更新日期:2000-07-01 00:00:00

  • A novel microneedle device for controlled and reliable liquid biopsy of the human inner ear.

    abstract::Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2019.06.004

    authors: Early S,Moon IS,Bommakanti K,Hunter I,Stankovic KM

    更新日期:2019-09-15 00:00:00

  • Intracellular recording of 'chopper responses' in the cochler nucleus of the cat.

    abstract::Intracellular recording of 'chopper responses' in the cochlear nucleus of the anesthetized cat presented a sustained depolarization accompanied by spikes that lasted as long as the stimulation. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(79)90020-0

    authors: Romand R

    更新日期:1979-03-01 00:00:00

  • Potential role of angiotensin II in noise-induced increases in inner ear blood flow.

    abstract::Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90128-5

    authors: Wright JW,Dengerink HA,Miller JM,Goodwin PC

    更新日期:1985-01-01 00:00:00

  • Evidence for a cochlear origin for acoustic re-emissions, threshold fine-structure and tonal tinnitus.

    abstract::Delayed acoustic waves have been measured in the sealed ear canal in response to click and tone-burst stimuli. The response shows compressive nonlinearity, evidence for 'active' processing, and frequency tuning. At low sound levels group and phase delays correspond, and represent about 15 waves delay for the mid-frequ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(80)90060-x

    authors: Wilson JP

    更新日期:1980-06-01 00:00:00

  • Spiral ganglion cell site of excitation II: numerical model analysis.

    abstract::An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2006.02.011

    authors: Cartee LA

    更新日期:2006-05-01 00:00:00

  • Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice.

    abstract::Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.107950

    authors: Claußen M,Schulze J,Nothwang HG

    更新日期:2020-06-01 00:00:00

  • Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later.

    abstract::Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.01.006

    authors: Fowler CG,Chiasson KB,Leslie TH,Thomas D,Beasley TM,Kemnitz JW,Weindruch R

    更新日期:2010-03-01 00:00:00

  • Exposure to low frequency noise during rearing induces spongiform lesions in gerbil cochlear nucleus: high frequency exposure does not.

    abstract::Spongiform lesions of the gerbil cochlear nucleus are reduced in number and extent by rearing in acoustic isolation compared with rearing while exposed to normal colony low-frequency background noise. This study tested whether rearing under exposure to noise bands of moderate intensity would increase the number and ex...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90153-8

    authors: McGinn MD,Faddis BT

    更新日期:1994-12-01 00:00:00

  • Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. III. Tuning curves and thresholds at CF.

    abstract::In order to study the effects of efferent activity, olivocochlear efferents were stimulated with an electrode in the fourth ventricle at the decussation of the crossed olivocochlear bundle (midline-OCB stimulation) or with an electrode at the brainstem origin of medial efferents (MOC stimulation). Tuning curves, or si...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90075-5

    authors: Guinan JJ Jr,Gifford ML

    更新日期:1988-12-01 00:00:00