Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis.

Abstract:

:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional distribution of intermediate cells. These cells constituted a honeycomb-like network, and their dendritic processes surrounded not only capillaries but also the basolateral surface of epithelial marginal cells. On the basis of the above finding and the large K(+) conductance in intermediate cells, we propose that the network composed of intermediate cells has a spatial K(+) buffering function. Transmission electron microscopy revealed the absence of the basal lamina in some regions and the presence of a gap junction-like membrane association between intermediate cells and pericytes and/or endothelial cells. This result supported our previous finding that intermediate cells were dye-coupled with pericytes and endothelial cells. The presence of gap junctions between intermediate cells and pericytes and/or endothelial cells suggests that endothelial cells and pericytes may play roles other than forming a structural route for blood circulation.

journal_name

Hear Res

journal_title

Hearing research

authors

Takeuchi S,Ando M,Sato T,Kakigi A

doi

10.1016/s0378-5955(01)00252-0

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

103-12

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(01)00252-0

journal_volume

155

pub_type

杂志文章
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  • Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea.

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