Abstract:
:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional distribution of intermediate cells. These cells constituted a honeycomb-like network, and their dendritic processes surrounded not only capillaries but also the basolateral surface of epithelial marginal cells. On the basis of the above finding and the large K(+) conductance in intermediate cells, we propose that the network composed of intermediate cells has a spatial K(+) buffering function. Transmission electron microscopy revealed the absence of the basal lamina in some regions and the presence of a gap junction-like membrane association between intermediate cells and pericytes and/or endothelial cells. This result supported our previous finding that intermediate cells were dye-coupled with pericytes and endothelial cells. The presence of gap junctions between intermediate cells and pericytes and/or endothelial cells suggests that endothelial cells and pericytes may play roles other than forming a structural route for blood circulation.
journal_name
Hear Resjournal_title
Hearing researchauthors
Takeuchi S,Ando M,Sato T,Kakigi Adoi
10.1016/s0378-5955(01)00252-0keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
103-12issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(01)00252-0journal_volume
155pub_type
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