Salicylate and quinine affect the central nervous system.

Abstract:

:Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251 single units recorded in AI response to periodic click train stimulation also decreased (from 10 Hz to 8.6 Hz) after application of these tinnitus-inducing drugs. The results strongly suggest a central effect of salicylates and quinine in addition to their peripheral ototoxic effects.

journal_name

Hear Res

journal_title

Hearing research

authors

Kenmochi M,Eggermont JJ

doi

10.1016/s0378-5955(97)00137-8

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

110-6

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(97)00137-8

journal_volume

113

pub_type

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