The frequency-modulation following response in young and aged human subjects.


:The frequency-modulation following response (FMFR) is a steady-state evoked response which may be a neural correlate of frequency discrimination. Aged subjects with normal hearing have abnormal frequency discrimination for low carrier frequencies and thus it might be predicted that aged individuals would have reduced FMFR amplitudes compared to young subjects. In this study, FMFR amplitudes were measured for frequency-modulated sinusoids with a carrier frequency of 0.5 kHz (80 dB SPL). In Experiment 1, the modulation depth was held constant (80%) and the modulation rate was varied (4-38 Hz), whereas in Experiment 2 the modulation rate was held constant (38 Hz) and the modulation depth was varied (0-80%). Aged subjects had significantly larger FMFR amplitudes than young subjects for certain stimulus parameters, although individual variability was large. Such results would not be predicted given previous data regarding frequency discrimination, but are consistent with several reports of larger-than-normal amplitudes of middle latency and late responses in aged subjects.


Hear Res


Hearing research


Boettcher FA,Madhotra D,Poth EA,Mills JH





Has Abstract


2002-03-01 00:00:00














  • The auditory neurobiology of marsupials: a review.

    abstract::The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Aitkin L

    更新日期:1995-02-01 00:00:00

  • Masked thresholds of auditory midbrain neurons in the frog Rana ridibunda.

    abstract::Single-unit recordings from neurons in the torus semicircularis of Rana ridibunda were analyzed to determine the degree to which these neurons can detect acoustic stimuli superimposed on continuous, broad-band noise. In the first series of trials the stimuli were tone pulses 25 ms long, 5 dB above threshold, and at th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Joermann G

    更新日期:1988-09-15 00:00:00

  • Effect of modulation of basilar membrane position on the cochlear microphonic.

    abstract::Certain characteristics of the extracellular cochlear microphonic (CM) recorded by intracochlear electrodes change in a bimodal manner as a function of prior acoustic exposure, intensity of stimulation, or stimulus frequency. In the present study, it is shown that biasing the basilar membrane position toward scala tym...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pierson M,Møller A

    更新日期:1980-03-01 00:00:00

  • Simulation of ILD sensitive neurons in the inferior colliculus of the barn owl.

    abstract::The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Peddicord R

    更新日期:1998-09-01 00:00:00

  • Transdifferentiation and its applicability for inner ear therapy.

    abstract::During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injurie...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Batts SA,Raphael Y

    更新日期:2007-05-01 00:00:00

  • 3CLT ABR analyses in a human subject with unilateral extirpation of the inferior colliculus.

    abstract::Reported are the results of analyses of three-channel Lissajous trajectories (3CLTs) of the auditory brain stem responses (ABRs) in a human subject in whom a focal lesion of the brain stem was caused by stereotactic radiosurgery, the 'gamma knife'. The surgery caused total destruction of the right inferior colliculus....

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Durrant JD,Martin WH,Hirsch B,Schwegler J

    更新日期:1994-01-01 00:00:00

  • GJB2 gene mutations in newborns with non-syndromic hearing impairment in Northern China.

    abstract::Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Shi GZ,Gong LX,Xu XH,Nie WY,Lin Q,Qi YS

    更新日期:2004-11-01 00:00:00

  • The mitochondrion: a perpetrator of acquired hearing loss.

    abstract::Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Böttger EC,Schacht J

    更新日期:2013-09-01 00:00:00

  • Nitric oxide induces hyperpolarization by opening ATP-sensitive K(+) channels in guinea pig spiral modiolar artery.

    abstract::Nitric oxide (NO) hyperpolarizes vascular smooth muscle cells and dilates blood vessels of various beds, but little is known on cochlear vasculatures. Using in vitro preparations of the spiral modiolar artery (SMA), intracellular electrical recording and labeling techniques, we found that the NO donor DPTA-NONOate (10...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Si JQ,Zhao H,Yang Y,Jiang ZG,Nuttall AL

    更新日期:2002-09-01 00:00:00

  • Carbohydrate distribution in the living utricular macula of the guinea pig detected by lectins.

    abstract::Carbohydrate distribution in the fresh utricular macula of the guinea pig was analysed using lectins such as Concanavalin A (ConA), Dolichos biflorus agglutinin (DBA), peanut agglutinin (PNA), soybean agglutinin (SBA), Ulex europeus agglutinin (UEA-1) and wheat germ agglutinin (WGA) by means of confocal laser scanning...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Suzuki H,Katori Y,Ikeda K,Takasaka T

    更新日期:1995-07-01 00:00:00

  • Conserved mechanisms of vocalization coding in mammalian and songbird auditory midbrain.

    abstract::The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Woolley SM,Portfors CV

    更新日期:2013-11-01 00:00:00

  • A speculation about the parallel ear asymmetries and sex differences in hearing sensitivity and otoacoustic emissions.

    abstract::Hearing sensitivity and the prevalence of spontaneous otoacoustic emissions show parallel ear and sex differences in humans. Here it is proposed that these lateral asymmetries and sex differences may all result from differences in the 'strength' of the efferent inhibition delivered to individual cochleas. Specifically...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: McFadden D

    更新日期:1993-08-01 00:00:00

  • Temperature sensitive auditory neuropathy.

    abstract::Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Zhang Q,Lan L,Shi W,Yu L,Xie LY,Xiong F,Zhao C,Li N,Yin Z,Zong L,Guan J,Wang D,Sun W,Wang Q

    更新日期:2016-05-01 00:00:00

  • Age-related shifts in distortion product otoacoustic emissions peak-ratios and amplitude modulation spectra.

    abstract::Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Lai J,Bartlett EL

    更新日期:2015-09-01 00:00:00

  • Forward and reverse transduction at the limit of sensitivity studied by correlating electrical and mechanical fluctuations in frog saccular hair cells.

    abstract::The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Denk W,Webb WW

    更新日期:1992-06-01 00:00:00

  • Characterisation of multiple physiological fields within the anatomical core of rat auditory cortex.

    abstract::The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Rutkowski RG,Miasnikov AA,Weinberger NM

    更新日期:2003-07-01 00:00:00

  • Intracellular Ca2+ buffers can dramatically affect Ca2+ conductances in hair cells.

    abstract::The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Martini M,Rispoli G,Farinelli F,Fesce R,Rossi ML

    更新日期:2004-09-01 00:00:00

  • Morphology of the endolymphatic sac in the guinea pig after an acute endolymphatic hydrops.

    abstract::The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES's epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microinjection of 1.1 mul artificial endolymph into scala media of the cochlea, guinea pigs we...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Valk WL,Wit HP,Segenhout JM,Dijk F,van der Want JJ,Albers FW

    更新日期:2005-04-01 00:00:00

  • A 3D-printed functioning anatomical human middle ear model.

    abstract::The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kuru I,Maier H,Müller M,Lenarz T,Lueth TC

    更新日期:2016-10-01 00:00:00

  • Supplemental iron exacerbates aminoglycoside ototoxicity in vivo.

    abstract::There is increasing evidence to suggest that free radical generation is central to a variety of pathological processes, including drug toxicity. Studies demonstrating the ability of gentamicin to facilitate the generation of radical species suggest that this process plays an important role in aminoglycoside-induced ot...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Conlon BJ,Smith DW

    更新日期:1998-01-01 00:00:00

  • Minimal sex differences in gene expression in the rat superior olivary complex.

    abstract::A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the wh...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Ehmann H,Salzig C,Lang P,Friauf E,Nothwang HG

    更新日期:2008-11-01 00:00:00

  • Objective auditory threshold estimation using sine-wave derived responses.

    abstract::A derived response method of acquiring frequency specific auditory evoked potentials that utilizes a pure tone in combination with a toneburst is applied to the measurement of hearing sensitivity in guinea pigs, chinchillas and pocket gophers. Two experiments which demonstrate that thresholds acquired via tone-derived...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Hood LJ,Berlin CI,Heffner RS,Morehouse CR,Smith EG,Barlow EK

    更新日期:1991-09-01 00:00:00

  • Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits.

    abstract::The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interfere...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

    更新日期:1999-10-01 00:00:00

  • Auditory training improves auditory performance in cochlear implanted children.

    abstract:UNLABELLED:While the positive benefits of pediatric cochlear implantation on language perception skills are now proven, the heterogeneity of outcomes remains high. The understanding of this heterogeneity and possible strategies to minimize it is of utmost importance. Our scope here is to test the effects of an auditory...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Roman S,Rochette F,Triglia JM,Schön D,Bigand E

    更新日期:2016-07-01 00:00:00

  • Permeability to sodium ions of the endolymph-perilymph barrier.

    abstract::The endocochlear potential and Na+ activity in the endolymph were simultaneously measured with a double-barreled Na+ selective liquid membrane electrode. The modified Na+ conductance and permeability coefficient of the endolymph-perilymph barrier were calculated from the rate of change in the endolymph Na+ concentrati...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Konishi T,Mori H

    更新日期:1984-08-01 00:00:00

  • Experimental investigation of promontory motion and intracranial pressure following bone conduction: Stimulation site and coupling type dependence.

    abstract:OBJECTIVES:Investigation of bone conduction sound propagation by osseous and non-osseous pathways and their interactions based upon the stimulation site and coupling method of the actuator from a bone conduction hearing aid (BCHA). METHODS:Experiments were conducted on five Thiel embalmed whole head cadaver specimens....

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Dobrev I,Sim JH,Pfiffner F,Huber AM,Röösli C

    更新日期:2019-07-01 00:00:00

  • Further validation of a binaural model predicting speech intelligibility against envelope-modulated noises.

    abstract::Collin and Lavandier [J. Acoust. Soc. Am. 134, 1146-1159 (2013)] proposed a binaural model predicting speech intelligibility against envelope-modulated noises, evaluated in 24 acoustic conditions, involving similar masker types. The aim of the present study was to test the model robustness modeling 80 additional condi...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Vicente T,Lavandier M

    更新日期:2020-05-01 00:00:00

  • The onset and post-onset auditory responses of cochlear nucleus neurons are modulated differently by cortical activation.

    abstract::Auditory cortex exhibit a capacity of modulating the functions of subcortical auditory nuclei and even inner ear through descending pathways. The cochlear nucleus (CN), which acts as the gateway from the auditory periphery to the central auditory system, is also subjected to corticofugal modulation. Cortical modulatio...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Liu X,Zhang O,Qi J,Chen A,Hu K,Yan J

    更新日期:2019-03-01 00:00:00

  • Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea.

    abstract::Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Takeda-Nakazawa H,Harada N,Shen J,Kubo N,Zenner HP,Yamashita T

    更新日期:2007-05-01 00:00:00

  • Frequency response for electromotility of isolated outer hair cells of the guinea pig.

    abstract::Frequency and impulse responses were determined for isolated guinea pig outer hair cells by electrically stimulating the cells between two wire electrodes with white noise. Cells were attached to the bottom of a small culture dish at one end while the other end was freely moving. Results have the character of a damped...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Wit HP,van Dijk P,Segenhout HM

    更新日期:1996-09-01 00:00:00