The frequency-modulation following response in young and aged human subjects.

Abstract:

:The frequency-modulation following response (FMFR) is a steady-state evoked response which may be a neural correlate of frequency discrimination. Aged subjects with normal hearing have abnormal frequency discrimination for low carrier frequencies and thus it might be predicted that aged individuals would have reduced FMFR amplitudes compared to young subjects. In this study, FMFR amplitudes were measured for frequency-modulated sinusoids with a carrier frequency of 0.5 kHz (80 dB SPL). In Experiment 1, the modulation depth was held constant (80%) and the modulation rate was varied (4-38 Hz), whereas in Experiment 2 the modulation rate was held constant (38 Hz) and the modulation depth was varied (0-80%). Aged subjects had significantly larger FMFR amplitudes than young subjects for certain stimulus parameters, although individual variability was large. Such results would not be predicted given previous data regarding frequency discrimination, but are consistent with several reports of larger-than-normal amplitudes of middle latency and late responses in aged subjects.

journal_name

Hear Res

journal_title

Hearing research

authors

Boettcher FA,Madhotra D,Poth EA,Mills JH

doi

10.1016/s0378-5955(01)00398-7

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

10-8

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378595501003987

journal_volume

165

pub_type

杂志文章
  • A physiological place-frequency map of the cochlea in the CBA/J mouse.

    abstract::Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.08.011

    authors: Müller M,von Hünerbein K,Hoidis S,Smolders JW

    更新日期:2005-04-01 00:00:00

  • A method for calibration of bone driver transducers to measure the mastoid impedance.

    abstract::When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.02.013

    authors: Weece R,Allen J

    更新日期:2010-05-01 00:00:00

  • Distortion product otoacoustic emission suppression tuning curves in human adults and neonates.

    abstract::Distortion product otoacoustic emission (DPOAE) iso-suppression tuning curves (STC) were generated in 15 normal-hearing adults and 16 healthy term-born neonates for three f2 frequencies. The 2f1-f2 DPOAE was elicited using f2/f1 = 1.2, LI = 1.2, LI = 65 and L2 = 50 dB SPL. A suppressor tone was presented at frequencie...

    journal_title:Hearing research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0378-5955(96)00056-1

    authors: Abdala C,Sininger YS,Ekelid M,Zeng FG

    更新日期:1996-09-01 00:00:00

  • A model for perilymphatic fistula induced hearing loss in the guinea pig cochlea.

    abstract::In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00389-1

    authors: Foster PK,Luebke AE

    更新日期:2002-05-01 00:00:00

  • Nitric oxide induces hyperpolarization by opening ATP-sensitive K(+) channels in guinea pig spiral modiolar artery.

    abstract::Nitric oxide (NO) hyperpolarizes vascular smooth muscle cells and dilates blood vessels of various beds, but little is known on cochlear vasculatures. Using in vitro preparations of the spiral modiolar artery (SMA), intracellular electrical recording and labeling techniques, we found that the NO donor DPTA-NONOate (10...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00497-5

    authors: Si JQ,Zhao H,Yang Y,Jiang ZG,Nuttall AL

    更新日期:2002-09-01 00:00:00

  • Effects of age on electrophysiological measures of cochlear synaptopathy in humans.

    abstract::Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.108068

    authors: Carcagno S,Plack CJ

    更新日期:2020-10-01 00:00:00

  • Current distributions in the cat cochlea: a modelling and electrophysiological study.

    abstract::The current distribution of bipolar electrodes implanted into the scala tympani of the cat cochlea was investigated using a two-electrode masking technique. Two electrode masking is a non-invasive technique which requires two electrically independent electrodes and relies upon the forward masking of the electrically e...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90044-9

    authors: O'Leary SJ,Black RC,Clark GM

    更新日期:1985-06-01 00:00:00

  • Simultaneous suppression of tone burst-evoked otoacoustic emissions--effect of level and presentation paradigm.

    abstract::There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on T...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2005.10.010

    authors: Killan EC,Kapadia S

    更新日期:2006-02-01 00:00:00

  • Frequency representation in the rat cochlea.

    abstract::In order to determine the place-frequency map of the rat cochlea, iontophoretic HRP-injections were made into the cochlear nucleus at electrophysiologically characterized positions. Distribution of retrograde HRP transport in cochlear spiral ganglion cells was analysed by means of a three dimensional reconstruction of...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(91)90041-7

    authors: Müller M

    更新日期:1991-02-01 00:00:00

  • Effects of hearing aid amplification on voice F0 variability in speakers with prelingual hearing loss.

    abstract::To investigate the audio-vocal feedback responses of (F0) to hearing amplification in severe-to-profound prelingual hearing loss (SPHL) using power spectral analysis of F0 contour of sustained vowels. Sustained phonations of vowel/a/of seventeen participants with SPHL were acquired with and without hearing-aid amplifi...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.04.010

    authors: Lee GS,Liu C,Lee SH

    更新日期:2013-08-01 00:00:00

  • Immunoelectron microscopic and immunofluorescent localization of cytoskeletal and muscle-like contractile proteins in inner ear sensory hair cells.

    abstract::The distribution of actin, alpha-actinin, fimbrin, tropomyosin and tubulin in the apical region of inner and outer hair cells was studied by immunofluorescent localization of antibodies to these proteins. The macromolecular distribution of actin and alpha-actinin was studied using post-embedding immunoelectron microsc...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90029-2

    authors: Slepecky N,Chamberlain SC

    更新日期:1985-01-01 00:00:00

  • Some organic acids attenuate the effects of furosemide on the endocochlear potential.

    abstract::A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90037-2

    authors: Rybak LP,Whitworth C

    更新日期:1987-01-01 00:00:00

  • A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support.

    abstract::Degeneration of spiral ganglion neurons (SGNs) in the cochlea following sensorineural hearing loss is preventable by the infusion of neurotrophins into the scala tympani. This study investigates the trophic effects and distribution of a single bolus infusion of neurotrophin-3 (NT3) into the scala tympani of the cochle...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2005.01.001

    authors: Richardson RT,O'Leary S,Wise A,Hardman J,Clark G

    更新日期:2005-06-01 00:00:00

  • Gentamicin is ototoxic to all hair cells in the fish lateral line system.

    abstract::Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.01.001

    authors: Van Trump WJ,Coombs S,Duncan K,McHenry MJ

    更新日期:2010-03-01 00:00:00

  • Tubulin expression in the developing and adult gerbil organ of Corti.

    abstract::In the late stages of inner ear development, the relatively undifferentiated cells of Kollicker's organ are transformed into the elaborately specialized cell types of the organ of Corti. Microtubules are prominent features of adult cells in the organ of Corti, particularly supporting cells. To test the possible role o...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00165-3

    authors: Hallworth R,McCoy M,Polan-Curtain J

    更新日期:2000-01-01 00:00:00

  • The effects of moderate and low levels of acoustic overstimulation on stereocilia and their tip links in the guinea pig.

    abstract::Guinea pigs were exposed to pure tones of 10 kHz at intensities between 98 and 115 dB SPL for 5-30 min, to produce varying degrees of acoustic trauma. Changes in auditory thresholds were measured electrophysiologically, and the animals were immediately fixed for scanning electron microscopy. Correlation between morpho...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(96)00092-5

    authors: Clark JA,Pickles JO

    更新日期:1996-09-15 00:00:00

  • Effects of adenosine 5'-triphosphate and related agonists on cochlear function.

    abstract::Several lines of evidence implicate a neurotransmitter/modulator role for ATP in the cochlea. Most of the work supporting such a notion has been accomplished using in vitro preparations of sensory hair cells or other cochlear tissues. Little is known regarding the functional consequences of ATP receptor activation in ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90091-4

    authors: Kujawa SG,Erostegui C,Fallon M,Crist J,Bobbin RP

    更新日期:1994-06-01 00:00:00

  • Pitch, harmonicity and concurrent sound segregation: psychoacoustical and neurophysiological findings.

    abstract::Harmonic complex tones are a particularly important class of sounds found in both speech and music. Although these sounds contain multiple frequency components, they are usually perceived as a coherent whole, with a pitch corresponding to the fundamental frequency (F0). However, when two or more harmonic sounds occur ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2009.09.012

    authors: Micheyl C,Oxenham AJ

    更新日期:2010-07-01 00:00:00

  • Ensemble spontaneous activity in the guinea-pig cochlear nerve.

    abstract::Spectral analysis of electrical noise recorded from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and changes in the spectral characteristics...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.02.006

    authors: Searchfield GD,Muñoz DJ,Thorne PR

    更新日期:2004-06-01 00:00:00

  • Immunocytochemical and quantitative studies of Na+,K+-ATPase distribution in the developing chick cochlea.

    abstract::Immunocytochemical methods were used to examine cryosections of the embryonic and neonatal chicken cochlea in order to study the histological distribution of the Na+,K+-ATPase molecule during maturation. In complementary studies the Na+,K+-ATPase capacity of microdissected freeze-dried substructures of the cochlea was...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90212-7

    authors: Schneider ME,Cotanche DA,Fambrough DM,Saunders JC,Matschinsky FM

    更新日期:1987-11-01 00:00:00

  • Effects of forskolin and 1,9-dideoxy-forskolin on cochlear potentials.

    abstract::Endocochlear potential (EP) and cochlear microphonics (CM) were recorded during the perilymphatic perfusion with forskolin known as an adenylate cyclase stimulant. Forskolin produced a reversible EP elevation in a dose-dependent manner. Perfusion with 1,9-dideoxy-forskolin, an analogue of forskolin that does not stimu...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90192-r

    authors: Doi K,Mori N,Matsunaga T

    更新日期:1990-04-01 00:00:00

  • Synaptic response patterns of neurons in the cortex of rat inferior colliculus.

    abstract::The present study examined synaptic potentials of neurons in inferior colliculus (IC) cortex slice and the roles of GABA and glutamate receptors in generating these potentials. Multipolar (82%) and elongated (18%) cells were observed with intracellular biocytin staining. Electrical stimulation of the IC commissure (Co...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00129-x

    authors: Li Y,Evans MS,Faingold CL

    更新日期:1999-11-01 00:00:00

  • Structural relationships of the unfixed tectorial membrane.

    abstract::Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00208-2

    authors: Ulfendahl M,Flock A,Scarfone E

    更新日期:2001-01-01 00:00:00

  • Auditory steady-state responses in cochlear implant users: Effect of modulation frequency and stimulation artifacts.

    abstract::Previous studies have shown that objective measures based on stimulation with low-rate pulse trains fail to predict the threshold levels of cochlear implant (CI) users for high-rate pulse trains, as used in clinical devices. Electrically evoked auditory steady-state responses (EASSRs) can be elicited by modulated high...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2016.03.006

    authors: Gransier R,Deprez H,Hofmann M,Moonen M,van Wieringen A,Wouters J

    更新日期:2016-05-01 00:00:00

  • Cochlear-implant spatial selectivity with monopolar, bipolar and tripolar stimulation.

    abstract::Sharp spatial selectivity is critical to auditory performance, particularly in pitch-related tasks. Most contemporary cochlear implants have employed monopolar stimulation that produces broad electric fields, which presumably contribute to poor pitch and pitch-related performance by implant users. Bipolar or tripolar ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2011.11.005

    authors: Zhu Z,Tang Q,Zeng FG,Guan T,Ye D

    更新日期:2012-01-01 00:00:00

  • Pre- and postsynaptic excitatory action of glutamate agonists on frog vestibular receptors.

    abstract::In order to investigate the localization and the type(s) of excitatory amino acid receptors in the frog vestibular system, the exogenous amino acid agonists Quisqualic acid, Kainic acid and N-methyl-D-aspartic acid were tested on the sensory organ of semicircular canals. Intracellular recordings of the resting dischar...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90006-b

    authors: Prigioni I,Russo G,Valli P,Masetto S

    更新日期:1990-07-01 00:00:00

  • A 3D-printed functioning anatomical human middle ear model.

    abstract::The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2015.12.025

    authors: Kuru I,Maier H,Müller M,Lenarz T,Lueth TC

    更新日期:2016-10-01 00:00:00

  • Recovery from prior stimulation. II: Effects upon intensity discrimination.

    abstract::We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(91)90107-k

    authors: Zeng FG,Turner CW,Relkin EM

    更新日期:1991-10-01 00:00:00

  • Auditory streaming based on temporal structure in hearing-impaired listeners.

    abstract::The influence of temporal cues on sequential stream segregation was investigated using five elderly hearing-impaired listeners. In experiment 1, an alternating pattern of A and B tones was used. Each tone was a harmonic complex with a 100-Hz fundamental, with one of three passbands (1250-2500, 1768-3636, or 2500-5000 ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.02.003

    authors: Stainsby TH,Moore BC,Glasberg BR

    更新日期:2004-06-01 00:00:00

  • Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.

    abstract::Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Muc...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2010.12.019

    authors: Schofield BR,Motts SD,Mellott JG

    更新日期:2011-09-01 00:00:00