Abstract：
:Several studies have been performed in which both the time-dependent and steady state output of cells in the dorsal nucleus of the lateral lemniscus (DNLL) have been measured in response to binaural sound stimulation. In this paper, a mathematical and computational model for the steady state output of DNLL cells is formulated. The model includes ascending connections from both lateral and medial superior olives (LSO and MSO) as well connections from interneurons in the DNLL and connections from the contralateral DNLL through the commissure of Probst. Our intent is to understand how the steady state behavior arises from the cell properties in and connectional patterns from lower brainstem nuclei. In particular, we examine the connectional hypotheses put forward by Markovitz and Pollak (1994) to explain the observed behavior of EI, EI/F, EE/I and EE/FI cells. Using these connections (with minor modifications) and cells with simple input-output relations, we are able to account for the steady state behavior of these cell types. We are able to explain interesting features of the data not commented on before, for example, the initial dip in spike output for EE cells at low ipsilateral sound levels. The presence of an inhibitory interneuron in the DNLL is essential for facilitation. In addition, we examine the effects of the MSO and the commissure of Probst on DNLL output. Furthermore, we propose a simple mechanism by which the cells of the DNLL and LSO could create a topographic place map in the inferior colliculus.
journal_name
Hear Resjournal_title
Hearing researchauthors
Reed MC,Blum JJdoi
10.1016/s0378-5955(99)00096-9keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
13-28issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(99)00096-9journal_volume
136pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Despite the common use of guinea pigs in investigations of the neural mechanisms of binaural and spatial hearing, their behavioral capabilities in spatial hearing tasks have surprisingly not been thoroughly investigated. To begin to fill this void, we tested the spatial hearing of adult male guinea pigs in several exp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.04.011
更新日期：2018-08-01 00:00:00
abstract：:Fluorescent tags and fluorophore-conjugated molecular probes have been extensively employed in histological studies to demonstrate nanoparticle distribution in inner ear cell populations. However, autofluorescence that exists in the rodent cochleae disturbs visualization of the fluorescent tags and fluorophore labelin...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.07.006
更新日期：2010-10-01 00:00:00
abstract：:New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...
journal_title：Hearing research
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Drugs of the salicylate family (aspirin-like drugs) are reversibly ototoxic. Electrophysiologic and ultrastructural evidence suggests an impairment of the sensory hair cells of the cochlea following salicylate treatment. In addition, since these drugs can cause vasoconstriction, the ototoxicity of salicylates may also...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90108-d
更新日期：1993-09-01 00:00:00
abstract：:Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in particular the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been described to be involved in the develo...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2012.03.002
更新日期：2012-06-01 00:00:00
abstract：:A common problem among the elderly is a difficulty in discriminating speech sounds. One factor that may contribute to this is a deterioration in the ability to process dynamic aspects of speech such as formant transitions. For the aging auditory system, this deterioration in temporal processing speed may be manifest a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00294-5
更新日期：2001-08-01 00:00:00
abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90074-6
更新日期：1983-08-01 00:00:00
abstract：:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00040-6
更新日期：2003-04-01 00:00:00
abstract：:This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90246-w
更新日期：1993-05-01 00:00:00
abstract：:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90064-7
更新日期：1994-05-01 00:00:00
abstract：:Compound action potentials (AP) were recorded under various stimulus conditions in 31 guinea pigs. Stimulus attenuation, decrease of inter-stimulus interval, increase of the level of a continuous wide-band noise maker, and lowering the animal's temperature all resulted in a drop of the AP amplitude and an increase in ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(81)90034-4
更新日期：1981-03-01 00:00:00
abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00131-8
更新日期：1999-11-01 00:00:00
abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.06.005
更新日期：2007-10-01 00:00:00
abstract：:In our companion paper (Le Calvez et al., 1998), the levels of distortion product otoacoustic emissions (DPOAE) were collected in the ears of CD1 mice with progressive degeneration of cochlear outer hair cells (OHC). Their comparison to standard functional measurements such as auditory-evoked brainstem responses (ABR)...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00051-3
更新日期：1998-06-01 00:00:00
abstract：:Aldosterone-Type I and dexamethasone-Type II/IB receptor complexes were identified in cytosol prepared from both cochlear and vestibular tissue samples. The specific binding capacity of Type I receptors in the cochlear tissues was approximately equal to that in the vestibular tissues. Likewise, the binding capacity of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90013-0
更新日期：1989-09-01 00:00:00
abstract：:Males and females differ in their subcortical evoked responses to sound. For many evoked response measures, the sex difference is driven by a faster developmental decline of auditory processing in males. Using the frequency-following response (FFR), an evoked potential that reflects predominately midbrain processing o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108075
更新日期：2020-12-01 00:00:00
abstract：:The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90189-9
更新日期：1994-04-01 00:00:00
abstract：:This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90016-t
更新日期：1993-12-01 00:00:00
abstract：:We have analyzed a model for the motion of hair bundles of hair cells at high frequencies. In the model, hair-cell organs are represented as a system of rigid mechanical structures surrounded by fluid. A rigid body, that represents a hair bundle, is hinged to a vibrating plate that represents the sensory epithelium. T...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90197-w
更新日期：1990-09-01 00:00:00
abstract：:Owing to the advances in transgenic animal technology and the advent of the next-generation sequencing era, over 120 genes causing hereditary hearing loss have been identified by now. In parallel, the field of human gene therapy continues to make exciting and rapid progress, culminating in the recent approval of sever...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2020.108092
更新日期：2020-10-15 00:00:00
abstract：:The focus of this study was to gauge the influence of intervening interference on an intensity standard held within auditory working memory through measurement of the just noticeable difference (JND) for intensity. Additionally, the use of interaural phase differences and interaural level differences as spatial cues w...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.04.004
更新日期：2008-06-01 00:00:00
abstract：:Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00260-4
更新日期：2001-03-01 00:00:00
abstract：:Previous studies have shown a reduction of the ototoxicity of furosemide in chinchillas pretreated with organic acid transport inhibitors. The current studies were designed to investigate whether such a protective effect could be observed in chinchillas receiving ethacrynic acid. Chinchillas weighing 400-600 g were in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90142-c
更新日期：1990-06-01 00:00:00
abstract：:We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00154-3
更新日期：1998-12-01 00:00:00
abstract：:Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.01.007
更新日期：2018-04-01 00:00:00
abstract：:Wavelength-swept optical coherence tomography (OCT) was used to scan the structure of cadaveric chinchilla ears in three dimensions with high spatial resolution and measure the sound-induced displacements of the entire OCT-visible lateral surfaces of the ossicles in the lateral-to-medial direction. The simultaneous me...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108056
更新日期：2020-10-01 00:00:00
abstract：:In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.12.002
更新日期：2019-03-01 00:00:00
abstract：:Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure, suggesting roles in energy expenditure and heat ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.02.002
更新日期：2004-10-01 00:00:00
abstract：:Recently it was shown that distortion product otoacoustic emissions (DPOAEs) can be measured as vibration of the human tympanic membrane in vivo, and proposed to use these vibration DPOAEs to support a differential diagnosis of middle-ear and cochlear pathologies. Here, we investigate how the reverse transfer function...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.04.015
更新日期：2011-10-01 00:00:00
abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.10.019
更新日期：2016-01-01 00:00:00
