Abstract:
:The cochlear microphonic (CM) is produced by a change in standing currents during the motion of the cochlear partition. The motion of the partition and associated hair cell transduction processes are nonlinear and are reflected in the variation of the instantaneous frequency (IF) of the CM. Although the CM is dominated from receptor currents from outer hair cells (OHCs), receptor currents from inner hair cells (IHCs) may contribute to the fluctuation in the IF. In this paper we examine the influence of IHCs on the variation of the IF of the CM. A 75 mg/kg intraperitoneal (i.p.) dose of carboplatin reduced the IHC population by approximately 40%. The reduction in IHCs did not substantially affect the amplitude of the CM. The amplitude of the IF, however, was reduced at high signal levels (90 and 100 dB peak SPL). A phenomenological model of the CM indicated that the contribution of IHC receptor currents to the IF was small and that changes in OHC transducer characteristics may have a greater impact on the IF.
journal_name
Hear Resjournal_title
Hearing researchauthors
Chertoff ME,Amani-Taleshi D,Guo Y,Burkard Rdoi
10.1016/s0378-5955(02)00642-1keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
93-100issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595502006421journal_volume
174pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90062-r
更新日期:1992-06-01 00:00:00
abstract::The C3H/lpr autoimmune strain mouse is a model for spontaneous systemic lupus erythematosus. Inner ear structure and function were examined during systemic autoimmune disease progression to identify correlated auditory system pathology. Onset of the systemic disease occurred at 2-3 months of age and was characterized ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90128-7
更新日期:1989-03-01 00:00:00
abstract::The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.05.009
更新日期:2004-09-01 00:00:00
abstract::Action potentials recorded extracellularly from neurons within the caudal cochlear nuclei of developing cats exhibited distinctive temporal characteristics (i.e., rhythmic responses) in response to long-duration acoustic stimuli including both tone and noise bursts. Unlike the homogeneous response characteristics of a...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(88)90065-2
更新日期:1988-11-01 00:00:00
abstract::The inner ear contains receptor cells that oscillate spontaneously, generating waves that propagate backward in the cochlea, ultimately causing sound to be radiated into the ear canal--the spontaneous otoacoustic emissions (SOAEs). Except in rare conditions, these internally generated signals appear to go unheard. The...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00388-x
更新日期:2002-09-01 00:00:00
abstract::The dose-response ototoxic effects of cisplatin were studied in guinea pigs. Loss of Preyer reflex and suppression of the N1 amplitude occurred in cisplatin-treated animals and was described as dose-related. Drug-induced hair cell damage, as observed with scanning electron microscopy, occurred sporadically throughout ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90104-3
更新日期:1987-01-01 00:00:00
abstract::In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.12.023
更新日期:2011-03-01 00:00:00
abstract::Carboplatin preferentially destroys inner hair cells (IHCs) in the chinchilla inner ear, while retaining a near-normal outer hair cell (OHC) population. The present study investigated the functional consequences of IHC loss on the compound action potential (CAP), inferior colliculus potential (ICP) and auditory cortex...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00171-9
更新日期:2000-01-01 00:00:00
abstract::Electrophysiological recordings in the dorsal cochlear nucleus (DCN) were conducted to determine the nature of changes in single unit activity following intense sound exposure and how they relate to changes in multiunit activity. Single and multiunit spontaneous discharge rates and auditory response properties were re...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.07.006
更新日期:2009-10-01 00:00:00
abstract::This study investigated the relation between the intelligibility of conversational and clear speech produced by older and younger adults and (a) the acoustic profile of their speech (b) communication effectiveness. Speech samples from 30 talkers from the elderLUCID corpus were used: 10 young adults (YA), 10 older adul...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.06.009
更新日期:2018-11-01 00:00:00
abstract::Tinnitus is a perception of sound that can occur in the absence of an external stimulus. A brief review of electroencephalography (EEG) and magnetoencephalography (MEG) literature demonstrates that there is no clear relationship between tinnitus presence and frequency band power in whole scalp or source oscillatory ac...
journal_title:Hearing research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.heares.2015.11.003
更新日期:2016-01-01 00:00:00
abstract::Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction i...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2009.10.006
更新日期:2010-01-01 00:00:00
abstract::This review is concerned with the operation of circuits in the central auditory system, how they transform response features and what functional significance may be attributed to those transformations. We focus on the role that GABAergic inhibition plays in processing interaural intensity disparities (IIDs), the princ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(02)00362-3
更新日期:2002-06-01 00:00:00
abstract::Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(02)00717-7
更新日期:2003-01-01 00:00:00
abstract::Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00211-6
更新日期:1998-03-01 00:00:00
abstract::In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2005.02.012
更新日期:2005-08-01 00:00:00
abstract::Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90174-3
更新日期:1989-08-01 00:00:00
abstract::Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as those with impaired audiograms. This study investigates the applicability of subco...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.07.001
更新日期:2019-09-01 00:00:00
abstract::This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00365-3
更新日期:2001-12-01 00:00:00
abstract::The mastoid air cell system has traditionally been considered to have a passive role in gas exchange and pressure regulation of the middle ear possibly with some acoustic function. However, more evidence has focused on the mucosa of the mastoid, which may play a more active role in regulation of middle ear pressure. I...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2013.03.002
更新日期:2013-07-01 00:00:00
abstract::Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024micros were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symm...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.12.001
更新日期:2009-02-01 00:00:00
abstract::The intra-cochlear distributions of aspartate aminotransferase and glutaminase, prominent enzymes of aspartate and glutamate metabolism, have been studied by quantitative microchemical techniques. Also measured was choline acetyltransferase, the enzyme synthesizing acetylcholine, and a marker for the olivocochlear bun...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(86)90058-4
更新日期:1986-01-01 00:00:00
abstract::Spongiform lesions of the gerbil cochlear nucleus are reduced in number and extent by rearing in acoustic isolation compared with rearing while exposed to normal colony low-frequency background noise. This study tested whether rearing under exposure to noise bands of moderate intensity would increase the number and ex...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90153-8
更新日期:1994-12-01 00:00:00
abstract::A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the wh...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.08.008
更新日期:2008-11-01 00:00:00
abstract::The possible presence of different types of delayed rectifier K+ current (I(K)) was studied in vestibular hair cells of frog semicircular canals. Experiments were performed in thin slice preparations of the whole crista ampullaris and recordings were made using the whole-cell patch-clamp technique. We found that an ap...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00097-0
更新日期:1999-09-01 00:00:00
abstract::Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. F...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.02.007
更新日期:2008-06-01 00:00:00
abstract::The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/0378-5955(94)00182-p
更新日期:1995-02-01 00:00:00
abstract::The Federal Food and Drug Administration, or FDA is generally considered a powerful gatekeeper, able to deliver or withhold life-saving cures and create or destroy economic windfalls. As the decades go by, and technologies, diseases, public health demands, and politics evolve, we can identify patterns of change, actio...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2016.11.006
更新日期:2017-06-01 00:00:00
abstract::High doses of salicylate induce reversible tinnitus in experimental animals and humans, and is a common tinnitus model. Salicylate probably acts centrally and induces hyperactivity in specific auditory brainstem areas like the dorsal cochlear nucleus (DCN). However, little is known about the effect of high doses of sa...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.10.008
更新日期:2016-02-01 00:00:00
abstract::Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2017.01.006
更新日期:2017-09-01 00:00:00