Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...

journal_title：Hearing research

authors： van Emst MG,Klis SF,Smoorenburg GF

更新日期：1995-08-01 00:00:00

abstract：:Strial marginal cells are known to take up and metabolize glucose as their main source of metabolic energy. The membrane transport mechanisms for glucose uptake into strial marginal cells, however, are largely unknown. Two types of glucose transporters in mammalian cells have been described, the facilitated glucose tr...

journal_title：Hearing research

authors： Takeuchi S,Ando M

更新日期：1997-12-01 00:00:00

abstract：:We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...

journal_title：Hearing research

authors： Patuzzi R,Moleirinho A

更新日期：1998-11-01 00:00:00

abstract：:The molecular composition and three-dimensional organization of the extracellular matrix (ECM) was studied by immunofluorescent microscopy, transmission and scanning electron microscopy in three connective tissue structures of the cochlea: the spiral limbus, basilar membrane and spiral ligament. Type II collagen, fibr...

journal_title：Hearing research

authors： Tsuprun V,Santi P

更新日期：1999-03-01 00:00:00

abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...

journal_title：Hearing research

authors： Orduña I,Mercado E 3rd,Gluck MA,Merzenich MM

更新日期：2001-10-01 00:00:00

abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...

journal_title：Hearing research

authors： Wang JA,Dong WJ,Chen JS

更新日期：1990-03-01 00:00:00

abstract：:Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell. The...

journal_title：Hearing research

authors： Cheatham MA,Dallos P

更新日期：1992-06-01 00:00:00

abstract：:Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...

journal_title：Hearing research

authors： Mockett BG,Bo X,Housley GD,Thorne PR,Burnstock G

更新日期：1995-04-01 00:00:00

abstract：:Recent evidence suggests that the monkey's short-term memory in audition depends on a passively retained sensory trace as opposed to a trace reactivated from long-term memory for use in working memory. Reliance on a passive sensory trace could render memory particularly susceptible to confusion between sounds that are...

journal_title：Hearing research

authors： Scott BH,Mishkin M,Yin P

更新日期：2013-04-01 00:00:00

abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...

journal_title：Hearing research

authors： Minoda R,Izumikawa M,Kawamoto K,Zhang H,Raphael Y

更新日期：2007-10-01 00:00:00

abstract：:Middle-ear to basilar membrane (BM) velocity transfer functions are reported for seven locations in the hook region of a single cat cochlea. These transfer functions were recorded at high sound pressure levels in a linearized, or passive cochlea, and resemble those reported previously by Wilson and Evans (1983). They ...

journal_title：Hearing research

authors： Cooper NP,Rhode WS

更新日期：1992-11-01 00:00:00

abstract：:It is known that the threshold of an acoustically induced middle-ear-muscle (MEM) reflex can be lowered by the simultaneous presentation of a second tone (facilitator), which is presented to the ipsilateral or contralateral ear at a level below the acoustic reflex threshold (ART) of the facilitator itself (Sesterhenn ...

journal_title：Hearing research

authors： Kawase T,Hidaka H,Takasaka T

更新日期：1997-06-01 00:00:00

abstract：:Both sound exposure and gentamicin treatment cause damage to sensory hair cells in the peripheral chick auditory organ, the basilar papilla. This induces a regeneration response which replaces hair cells and restores auditory function. Since functional recovery requires the re-establishment of connections between rege...

journal_title：Hearing research

authors： Ofsie MS,Hennig AK,Messana EP,Cotanche DA

更新日期：1997-11-01 00:00:00

abstract：:Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the...

journal_title：Hearing research

authors： Carcagno S,Plack CJ

更新日期：2020-10-01 00:00:00

abstract：:High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...

journal_title：Hearing research

authors： Chen GD,Stolzberg D,Lobarinas E,Sun W,Ding D,Salvi R

更新日期：2013-01-01 00:00:00

abstract：:Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ETARs) in glomerular pathogenesis. Here w...

journal_title：Hearing research

authors： Meehan DT,Delimont D,Dufek B,Zallocchi M,Phillips G,Gratton MA,Cosgrove D

更新日期：2016-11-01 00:00:00

abstract：:Immunocytochemical methods were used to examine cryosections of the embryonic and neonatal chicken cochlea in order to study the histological distribution of the Na+,K+-ATPase molecule during maturation. In complementary studies the Na+,K+-ATPase capacity of microdissected freeze-dried substructures of the cochlea was...

journal_title：Hearing research

authors： Schneider ME,Cotanche DA,Fambrough DM,Saunders JC,Matschinsky FM

更新日期：1987-11-01 00:00:00

abstract：:The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial...

journal_title：Hearing research

authors： Marco RA,Hoffman LF,Wackym PA,Micevych PE,Popper P

更新日期：1996-08-01 00:00:00

abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...

journal_title：Hearing research

authors： Dechesne CJ,Kim HN,Nowak TS Jr,Wenthold RJ

更新日期：1992-05-01 00:00:00

abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...

journal_title：Hearing research

authors： Cacace AT

更新日期：2003-01-01 00:00:00

abstract：:During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. I...

journal_title：Hearing research

authors： Wit HP,Warmerdam TJ,Albers FW

更新日期：2000-07-01 00:00:00

abstract：:This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...

journal_title：Hearing research

authors： Popelka GR,Osterhammel PA,Nielsen LH,Rasmussen AN

更新日期：1993-12-01 00:00:00

abstract：:The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same through...

journal_title：Hearing research

authors： Park JC,Hubel SB,Woods AD

更新日期：1987-01-01 00:00:00

abstract：:Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in particular the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been described to be involved in the develo...

journal_title：Hearing research

authors： Ramekers D,Versnel H,Grolman W,Klis SF

更新日期：2012-06-01 00:00:00

abstract：:Actin mRNA was characterised in hair-cell enriched fractions of the chick basilar papilla, by means of the reverse-transcription polymerase chain reaction technique. Primers were directed against the 3' untranslated portions of the actin mRNAs. Evidence for beta-cytoplasmic and gamma-cytoplasmic actin mRNA was found; ...

journal_title：Hearing research

authors： Pickles JO

更新日期：1993-12-01 00:00:00

abstract：:This paper describes the development of a protocol that can be used to detect collagen II in the healthy adult basilar membrane (BM) at the electron microscopic level. This protocol required aggressive epitope exposure techniques to break the crosslinks that bind the collagen molecules tightly into fibrils and to remo...

journal_title：Hearing research

authors： Dreiling FJ,Henson MM,Henson OW Jr

更新日期：2002-04-01 00:00:00

abstract：:Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...

journal_title：Hearing research

authors： Kaukoranta E,Sams M,Hari R,Hämäläinen M,Näätänen R

更新日期：1989-08-01 00:00:00

abstract：:The superior colliculus (SC) is critical for directing accurate head and eye movements to visual and acoustic targets. In visual cortex, areas involved in orienting of the head and eyes to a visual stimulus have direct projections to the SC. In auditory cortex of the cat, four areas have been identified to be critical...

journal_title：Hearing research

authors： Chabot N,Mellott JG,Hall AJ,Tichenoff EL,Lomber SG

更新日期：2013-06-01 00:00:00

abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...

journal_title：Hearing research

authors： Brown DJ,McMahon CM,Patuzzi RB

更新日期：2004-04-01 00:00:00

abstract：:Healthy guinea pigs were exposed to broad band noise at levels between 95 and 115 dBA for 7 days. A significant decrease of the sound-induced cochlear responses, together with a substantial increase of the endocochlear potential, was observed in guinea pigs exposed to noise at 105 or 115 dBA. Microsamples of the endol...

journal_title：Hearing research

authors： Konishi T,Salt AN,Hamrick PE

更新日期：1979-12-01 00:00:00