Abstract：
:During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injuries as well as regeneration largely depends on the activation of stem cell reserves. The mature cochlea is an exception among epithelial cell layers in that it lacks stem cells. Consequently, the sensory hair cells that receive sound information cannot be replaced, and their loss results in permanent hearing impairment. The lack of a spontaneous cell replacement mechanism in the organ of Corti, the mammalian auditory sensory epithelium, has led researchers to investigate circumstances in which transdifferentiation does occur. The hope is that this information can be used to design therapies to replace lost hair cells and restore impaired hearing in humans.
journal_name
Hear Resjournal_title
Hearing researchauthors
Batts SA,Raphael Ydoi
10.1016/j.heares.2006.08.015subject
Has Abstractpub_date
2007-05-01 00:00:00pages
41-7issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(06)00245-0journal_volume
227pub_type
杂志文章,评审相关文献
HEARING RESEARCH文献大全abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00133-6
更新日期：1998-10-01 00:00:00
abstract：:The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the super...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.04.004
更新日期：2006-08-01 00:00:00
abstract：:Age pigment in the sensory and supporting cells was a prominent characteristic distinguishing old saccules from young. However, the pigment was not distributed uniformly throughout the sensory epithelium but displayed cell-specific patterns of accumulation. The highest cytoplasmic volume density was in the old support...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90038-5
更新日期：1989-01-01 00:00:00
abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00159-7
更新日期：1997-12-01 00:00:00
abstract：:Using a quantitative microchemical mapping approach combined with surgical cuts of fiber tracts, the contributions of centrifugal pathways to choline acetyltransferase activity were mapped three-dimensionally in the cat cochlear nucleus. Large reductions of choline acetyltransferase activity, averaging 70%, were measu...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90108-2
更新日期：1990-11-01 00:00:00
abstract：:The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90045-7
更新日期：1988-09-01 00:00:00
abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00005-1
更新日期：1997-04-01 00:00:00
abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.03.007
更新日期：2009-07-01 00:00:00
abstract：:Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each p...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.03.021
更新日期：2005-07-01 00:00:00
abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90127-9
更新日期：1992-03-01 00:00:00
abstract：:Input-specific remodeling is observed both in the primary auditory cortex (AI) and the ventral division of the medial geniculate body of the thalamus (MGBv) through motivation such as learning. Here, we show the role of AI in the MGBv remodeling induced by the electrical stimulation (ES) of the central division of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.06.016
更新日期：2015-10-01 00:00:00
abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00038-1
更新日期：2000-06-01 00:00:00
abstract：:The primary goal of most cochlear implant procedures is to improve a patient's ability to discriminate speech. To accomplish this, cochlear implants are programmed so as to maximize speech understanding. However, programming a cochlear implant can be an iterative, labor-intensive process that takes place over months. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.11.007
更新日期：2014-03-01 00:00:00
abstract：:Auditory cortex exhibit a capacity of modulating the functions of subcortical auditory nuclei and even inner ear through descending pathways. The cochlear nucleus (CN), which acts as the gateway from the auditory periphery to the central auditory system, is also subjected to corticofugal modulation. Cortical modulatio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.12.013
更新日期：2019-03-01 00:00:00
abstract：:Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00047-2
更新日期：2000-06-01 00:00:00
abstract：:The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10 kHz tone). Hyperactivity was present by 12 h post acoustic trauma whereas data obtained withi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.12.008
更新日期：2013-04-01 00:00:00
abstract：:The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：:Recent studies have shown that the vestibular and auditory systems of some species of birds have the capacity to generate sensory hair cells postnatally. We used a traditional technique, 3H-thymidine autoradiography, and a newer method, bromodeoxyuridine immunocytochemistry, to determine whether ongoing proliferation ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90149-h
更新日期：1992-01-01 00:00:00
abstract：:In this study, which aims to investigate for the first time auditoty sensitivity in congenital central hypothyroidism (CH), we concluded that: (1) permanent sensorineural hearing loss may be observed not only in congenital primary disorders of thyroid function, as reported hitherto; (2) it may also be found in patient...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00515-4
更新日期：2002-10-01 00:00:00
abstract：:Cochleotopic representation in cortex (AI) is extensively reorganized in cats having neonatal, bilateral high frequency cochlear hearing loss. Anterior areas of AI, normally devoted to high frequencies, contain neurons which are almost all tuned to one lower frequency. This frequency corresponds, at the level of the c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90131-r
更新日期：1991-07-01 00:00:00
abstract：:Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell. The...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90052-o
更新日期：1992-06-01 00:00:00
abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00131-8
更新日期：1999-11-01 00:00:00
abstract：:Polyclonal antibodies were raised in chickens to the glycosylated forms of the high (H), medium (M) and low (L) molecular mass (MM) mouse tectorins. In the mouse cochlea, all three antibodies stained the tectorial membrane. Antibodies raised to HMM tectorin also stained the hair bundles of both inner and outer hair ce...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00174-8
更新日期：1997-01-01 00:00:00
abstract：:The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00142-6
更新日期：1996-11-01 00:00:00
abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90049-7
更新日期：1993-10-01 00:00:00
abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00404-0
更新日期：2004-04-01 00:00:00
abstract：:Human subjects performed in several behavioral conditions requiring, or not requiring, selective attention to visual stimuli. Specifically, the attentional task was to recognize strings of digits that had been presented visually. A nonlinear version of the stimulus-frequency otoacoustic emission (SFOAE), called the nS...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.03.013
更新日期：2014-06-01 00:00:00
abstract：:Cochlear serotonergic innervation is constituted by efferent fibers projecting both to the area below the inner and the outer hair cells. Previous detection of serotonin (5-HT) metabolites and 5-HT receptor mRNAs suggests the existence of serotonergic synaptic activity in the cochlea. The present study explores this p...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00140-0
更新日期：2003-08-01 00:00:00
abstract：:Alterations in the distribution and activity of Na,K-ATPase have been implicated in declining cell function with age. However, the location, size and anatomical complexity of the cochlea have limited study of this essential enzyme. Here we describe a micro-colorimetric assay which measures Na,K-ATPase activity in subr...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)00188-v
更新日期：1995-03-01 00:00:00
