Abstract:
:Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with noise-induced compound action potential (CAP) threshold elevation at corresponding frequencies. CAP threshold elevation and hair cell loss were determined 4 weeks after noise exposure. In the apical turn (<35% from the apex) there was no hair cell loss even when a 60 dB CAP threshold elevation was induced. In the region of 40-60% from the apex in the middle turn, significant hair cell loss was not observed until CAP threshold elevation exceeded about 40-50 dB. This critical level decreased towards the basal turn. In the basal turn, outer hair cell (OHC) loss was observed in almost all of the noise-exposed rats, even in some cases without detectable NIHL, but inner hair cell (IHC) loss was still not observed until 50 dB threshold elevation. In the region of 75-90% from the apex related to the highest frequencies tested in this study (30-40 kHz), a linear NIHL/OHC loss relationship was observed. The results of this paper suggest that the high frequency hair cells in rat cochlea may die relatively rapidly after injury, leading to a linear relation between NIHL and hair cell loss, but that the low frequency hair cells may survive without auditory function.
journal_name
Hear Resjournal_title
Hearing researchauthors
Chen GD,Fechter LDdoi
10.1016/s0378-5955(02)00802-xkeywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
81-90issue
1-2eissn
0378-5955issn
1878-5891pii
S037859550200802Xjournal_volume
177pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(00)00127-1
更新日期:2000-09-01 00:00:00
abstract::Measurements were made of inner hair cell receptor potentials and basilar membrane motion in the 17-21 kHz region of the guinea pig cochlea. The latter were made using the Mossbauer technique. Isoamplitude curves at 0.9 mV d.c. receptor potential were compared with isovelocity curves at 0.04 mm/s and the corresponding...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90019-9
更新日期:1983-04-01 00:00:00
abstract::The amplitude values of transient-evoked otoacoustic emissions, recorded from a large sample of neonates, were used to examine the asymmetry between ears tested and the differences due to the sex of the subject. Whilst the sex difference, with females having larger responses than males, has been a consistent finding i...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00234-x
更新日期:2003-10-01 00:00:00
abstract::To examine the reversibility of functional damage to the cochlea after transient ischemia, cochlear ischemia of 0-60 min was induced in 34 albino guinea pigs. Thresholds of auditory brainstem response (ABR) were then followed for 5 days after ischemia. Although the ABR threshold returned to almost the pre-ischemic val...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00299-x
更新日期:2002-04-01 00:00:00
abstract::The ototoxic effects of salicylates, reversible hearing loss and tinnitus, are well documented. However, the pharmacological mechanisms underlying these changes in cochlear function are not well understood. The studies reported here were an investigation of the site and mechanism of salicylate ototoxicity through an e...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90144-e
更新日期:1990-06-01 00:00:00
abstract::Recently, ocular vestibular evoked myogenic potentials (oVEMPs) have been described and added to the neuro-otologic test battery as a new measure for the vestibulo-ocular reflex. oVEMPs represent extraocular muscle activity in response to otolith stimulation e.g. by air-conducted sound or bone-conducted vibration. In ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2012.10.008
更新日期:2012-12-01 00:00:00
abstract::Blind cave fish use the lateral line sensory system to detect nearby objects. The fish responds to sudden perturbations in the water column by initiating startle responses in which they swim more rapidly. Normal startle responses disappear after trauma caused by a single 15 s immersion in calcium free water, but retur...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00226-x
更新日期:2001-04-01 00:00:00
abstract::There is convincing evidence that cochlear microphonics (CM) arise primarily from outer hair cells and have a frequency distribution that is much broader than that measured in inner hair cells by Russel and Sellick [6,7]. The broad tuning results from the fact that CM generated at each location decays exponentially al...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(80)90092-1
更新日期:1980-06-01 00:00:00
abstract::The stimulus level and frequency dependence of the quadratic difference tone (QDT) measured as an otoacoustic emission in the ear canal has been investigated in the guinea pig and compared with simultaneously measured cubic difference tone (CDT) and with the round window electrical response. Acoustic QDT level tended ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90154-s
更新日期:1993-11-01 00:00:00
abstract::We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.07.014
更新日期:2014-10-01 00:00:00
abstract::Receptors which bind the neurotrophins NGF, BDNF, NT-3 and NT-4/5 were shown to be present in cochlear and vestibular ganglion cells during development, implying a neurotrophic role for these molecules in the inner ear. We have found by in situ hybridization that cochlear and vestibular sensory epithelial cells expres...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90286-0
更新日期:1994-02-01 00:00:00
abstract::When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses record...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00016-7
更新日期:1999-04-01 00:00:00
abstract::Temporary threshold shifts (TTS), of the cochlear action potential in the guinea pig, caused by a high frequency exposure tone could be reduced by a prior exposure at the same frequency but lower intensity. The TTS caused by the initial, low intensity exposure tone was allowed to recover to levels where the thresholds...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90105-3
更新日期:1983-11-01 00:00:00
abstract::The pupil dilation response is sensitive both to listening effort and the emotional significance of a task. We aimed to assess the influence of evaluative feedback on the pupil dilation response using a speech reception threshold (SRT) task. Besides the pupil dilation response, we acquired subjective ratings and two p...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.07.005
更新日期:2019-09-15 00:00:00
abstract::Transtympanic administration of gentamicin is a widely accepted and effective approach for treating patients with intractable vertigo. Previous studies have demonstrated the uptake, distribution and effects of gentamicin in peripheral vestibular and cochlear structures after transtympanic injection. However, little is...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.10.003
更新日期:2012-01-01 00:00:00
abstract::Electrical stimulation of the cochlea with a multiple-electrode array is best accomplished using pulsatile instead of continuous stimulation. The optimum shapes of electrical pulses for this purpose are still uncertain due to a lack of knowledge about their stimulation efficiency and requirements of the encoding strat...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90045-2
更新日期:1989-06-01 00:00:00
abstract::Syndromic hearing loss accounts for approximately 30% of all cases of hearing loss due to genetic causes. Mutation screening in known genes is important because it potentially sheds light on the genetic etiology of hearing loss and helps in genetic counseling of families. In this study, we describe a customized Ion Am...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.10.008
更新日期:2018-12-01 00:00:00
abstract::The rather shallow growth of click-evoked otoacoustic emissions (CEOAE) with click intensity, namely <1 dB/dB, distinguishes genuine CEOAEs from stimulus artifacts, thereby providing the rationale for the popular 'derived nonlinear recording' method. However, other CEOAE nonlinearities regarding phase or envelope depe...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00745-1
更新日期:2003-01-01 00:00:00
abstract::The endocochlear potential (EP) provides part of the electrochemical drive for sound-driven currents through cochlear hair cells. Intense noise exposure (110 dB SPL, 2 h) differentially affects the EP in three inbred mouse strains (C57BL/6 [B6], CBA/J [CBA], BALB/cJ [BALB]) (Ohlemiller and Gagnon, 2007, Hearing Resear...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::The current distribution of bipolar electrodes implanted into the scala tympani of the cat cochlea was investigated using a two-electrode masking technique. Two electrode masking is a non-invasive technique which requires two electrically independent electrodes and relies upon the forward masking of the electrically e...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90044-9
更新日期:1985-06-01 00:00:00
abstract::The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00232-4
更新日期:1996-05-01 00:00:00
abstract::Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90049-7
更新日期:1993-10-01 00:00:00
abstract::Normal-hearing listeners can perceptually segregate concurrent sound sources, but listeners with significant hearing loss or who wear a cochlear implant (CI) lag behind in this ability. Perceptual grouping mechanisms are essential to segregate concurrent sound sources and affect comodulation masking release (CMR). Thu...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.11.023
更新日期:2013-02-01 00:00:00
abstract::In this series of behavioural experiments we investigated the effect of distraction on the maintenance of acoustic scene information in short-term memory. Stimuli are artificial acoustic 'scenes' composed of several (up to twelve) concurrent tone-pip streams ('sources'). A gap (1000 ms) is inserted partway through the...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.08.015
更新日期:2016-11-01 00:00:00
abstract::The protective efficacy of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) at 1 or 10 microg/ml was assessed in guinea pigs exposed to 4 kHz octave band noise at 115 dB SPL for 5 h. BDNF, NT-3 or artificial perilymph was delivered to the scala tympani via a mini-osmotic pump, beginning 4 days prior ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00106-4
更新日期:2000-08-01 00:00:00
abstract::We examined the frequency specificity of amplitude envelope patterns in 4 frequency bands, which universally appeared through factor analyses applied to power fluctuations of critical-band filtered speech sounds in 8 different languages/dialects [Ueda and Nakajima (2017). Sci. Rep., 7 (42468)]. A series of 3 perceptua...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.06.005
更新日期:2018-09-01 00:00:00
abstract::This paper reviews the contributions of von Békésy to psychoacoustics, comparing his findings and interpretations to those that have emerged since his work. The areas covered include the perception of pitch for pure tones and complex tones, the effect of frequency on the apparent location of pure tones, estimation of ...
journal_title:Hearing research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.heares.2012.04.009
更新日期:2012-11-01 00:00:00
abstract::Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00063-5
更新日期:1999-07-01 00:00:00
abstract::The relation between hearing loss and loss of hair cells after prolonged exposure to a simulated industrial noise environment was determined in normotensive albino rats. Hearing loss was assessed behaviorally by a conditioned suppression technique and electrophysiologically by auditory brainstem response to pulses of ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(87)90129-8
更新日期:1987-01-01 00:00:00
abstract::The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90289-5
更新日期:1994-02-01 00:00:00