Atypical Ductal Lesions of the Breast: Criteria, Significance, and Laboratory Updates.

Abstract:

CONTEXT.—:Atypical ductal hyperplasia (ADH) is a challenging diagnosis defined by cytologic and architectural features that carries an increased risk of subsequent carcinoma when diagnosed in isolation. In addition, ADH may secondarily involve benign breast lesions, wherein it carries variable clinical significance. OBJECTIVES.—:To review the diagnostic criteria and clinical significance of ADH in isolation and as it involves benign breast lesions, and to review the evolving literature on its molecular signature. DATA SOURCES.—:Recently published studies that collectively examine ADH were reviewed. CONCLUSIONS.—:Atypical ductal hyperplasia carries an increased risk of subsequent carcinoma in isolation and when it involves most benign breast lesions. Identifying which cases of ADH will be upgraded to carcinoma has been challenging, and new laboratory developments, such as EZH2 overexpression, may have a future role.

journal_name

Arch Pathol Lab Med

authors

East EG,Carter CS,Kleer CG

doi

10.5858/arpa.2018-0221-RA

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1182-1185

issue

10

eissn

0003-9985

issn

1543-2165

journal_volume

142

pub_type

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