当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > The changing scenario of hepatitis D.

The changing scenario of hepatitis D.

Abstract：

:The global scenario of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent the end stage of the natural history of HDV, and of a younger generation of immigrants from endemic countries who account for the majority of new infections. Similar to the features in Europe in the 1980s, in endemic countries the distinctive clinical characteristic of chronic hepatitis D is the accelerated progression to cirrhosis and hepatocellular carcinoma. Despite some recent progress, the therapeutic management of HDV remains unsatisfactory, as most patients are not cured of HDV with currently available medicines. This review article describes the current epidemiology and clinical features of chronic hepatitis D, based on the international literature of the last ten years.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Rizzetto M,Hamid S,Negro F

doi

10.1016/j.jhep.2021.01.014

subject

Has Abstract

pub_date

2021-01-20 00:00:00

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(21)00023-4

pub_type

杂志文章,评审

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?

    abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney dise...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2010.11.007

    authors： Targher G,Chonchol M,Zoppini G,Abaterusso C,Bonora E

    更新日期：2011-05-01 00:00:00

  • Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are perisinusoidal pericytes which have receptors for vasoactive factors, such as endothelin-1, which can regulate cell contractility in an autocrine manner. It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedulli...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00016-7

    authors： Görbig MN,Ginès P,Bataller R,Nicolás JM,Garcia-Ramallo E,Cejudo P,Sancho-Bru P,Jiménez W,Arroyo V,Rodés J

    更新日期：2001-02-01 00:00:00

  • A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure.

    abstract：BACKGROUND & AIMS:Animal models and human case series of acute liver failure (ALF) suggest moderate hypothermia (MH) to have protective effects against cerebral oedema (CO) development and intracranial hypertension (ICH). However, the optimum temperature for patient management is unknown. In a prospective randomized co...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jhep.2016.03.003

    authors： Bernal W,Murphy N,Brown S,Whitehouse T,Bjerring PN,Hauerberg J,Frederiksen HJ,Auzinger G,Wendon J,Larsen FS

    更新日期：2016-08-01 00:00:00

  • Applicability of adult-to-adult living donor liver transplantation.

    abstract：BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.02.016

    authors： Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

    更新日期：2005-07-01 00:00:00

  • Treatment with peg-interferon alfa-2b and ribavirin of hepatitis C virus-associated mixed cryoglobulinemia: a pilot study.

    abstract：BACKGROUND/AIMS:The aim of this study is to verify the efficacy and safety of peg-interferon alfa-2b in combination with ribavirin for initial treatment of HCV-associated mixed cryoglobulinemia. METHODS:Eighteen patients (7 women and 11 men) affected by mixed cryoglobulinemia were included in the study and treated wit...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jhep.2004.10.031

    authors： Mazzaro C,Zorat F,Caizzi M,Donada C,Di Gennaro G,Maso LD,Carniello G,Virgolini L,Tirelli U,Pozzato G

    更新日期：2005-05-01 00:00:00

  • Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice.

    abstract：BACKGROUND & AIMS:ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP. IL-1α is localized to the nucleus in apoptotic cells, but is released when these cells become necrotic and...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.05.012

    authors： Kandel-Kfir M,Almog T,Shaish A,Shlomai G,Anafi L,Avivi C,Barshack I,Grosskopf I,Harats D,Kamari Y

    更新日期：2015-10-01 00:00:00

  • Effects of ursodeoxycholate, its glucuronide and disulfate and beta-muricholate on biliary bicarbonate concentration and biliary lipid excretion.

    abstract：:We previously reported that high-dose ursodeoxycholate (UDC) infusion in rats resulted in extensive glucuronidation of UDC, and speculated that the glucuronidation causes bicarbonate-rich hypercholeresis induced by UDC (Takikawa, H., Sano, N., Narita, T. and Yamanaka, M. Hepatology 1990; 11: 743-749). To test this hyp...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90015-h

    authors： Takikawa H,Sano N,Minagawa K,Yamanaka M

    更新日期：1992-05-01 00:00:00

  • HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production.

    abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) has developed strategies to evade immune responses. However, the mechanisms involved remain unclear. The NLRP3 inflammasome plays crucial roles in antiviral host defense and its downstream factor IL-1β has been shown to inhibit HBV infection in vivo. This study aims to assess w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.12.018

    authors： Yu X,Lan P,Hou X,Han Q,Lu N,Li T,Jiao C,Zhang J,Zhang C,Tian Z

    更新日期：2017-04-01 00:00:00

  • Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis.

    abstract：BACKGROUND & AIMS:Primary biliary cirrhosis (PBC) is believed to result from the interaction of genetic and environmental factors. The controlled studies aiming to assess risk factors for PBC are still limited. Our aim was to identify risk factors and co-morbidities associated with PBC in a large monocentric cohort. M...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.02.019

    authors： Corpechot C,Chrétien Y,Chazouillères O,Poupon R

    更新日期：2010-07-01 00:00:00

  • Interleukins in chronic active hepatitis B. Relationship with viral markers.

    abstract：:Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80059-4

    authors： Civeira M,Prieto J,Morte S,Riñon M,Serrano M

    更新日期：1987-08-01 00:00:00

  • Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients.

    abstract：BACKGROUND & AIMS:Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. It is unknown how physicians' experience has impacted on the management of these AEs and consequently on clinical outcomes. We aimed to assess whether AE management changed over time and if thes...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.08.015

    authors： Tovoli F,Ielasi L,Casadei-Gardini A,Granito A,Foschi FG,Rovesti G,Negrini G,Orsi G,Renzulli M,Piscaglia F

    更新日期：2019-12-01 00:00:00

  • Differential effect of ARA-AMP on serum DNA polymerase activity and serum HBV-DNA in chronic hepatitis B virus infection. A possible reason for lack of efficacy.

    abstract：:An uncontrolled pilot study of adenine arabinoside monophosphate intramuscularly (ARA-AMP) for 5 days at 10 mg/kg/day and 23 days at 5 mg/kg/day in divided doses, was conducted in 15 consecutive patients known to be HBeAg-positive for a minimum of 12 months. Two patients were lost to follow-up (1 having developed an h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80104-0

    authors： Alexander GJ,Fagan EA,Rolando N,Guarner P,Callender ME,Eddleston AL,Williams R

    更新日期：1986-01-01 00:00:00

  • Gallbladder disease is associated with insulin resistance in a high risk Hispanic population.

    abstract：BACKGROUND/AIMS:We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population. METHODS:This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Ins...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.01.026

    authors： Nervi F,Miquel JF,Alvarez M,Ferreccio C,García-Zattera MJ,González R,Pérez-Ayuso RM,Rigotti A,Villarroel L

    更新日期：2006-08-01 00:00:00

  • Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.

    abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.09.014

    authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

    更新日期：2020-01-01 00:00:00

  • Effects of propranolol and sucralfate on ethanol-induced gastric mucosal damage in chronic portal hypertensive rats.

    abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80568-8

    authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

    更新日期：1987-10-01 00:00:00

  • Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: a prospective randomized study.

    abstract：BACKGROUND/AIMS:Although ursodeoxycholic acid is effective for the treatment of primary biliary cirrhosis, some patients do not respond to this treatment. The objective of the present study was to investigate the effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary bi...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(96)80191-7

    authors： Ikeda T,Tozuka S,Noguchi O,Kobayashi F,Sakamoto S,Marumo F,Sato C

    更新日期：1996-01-01 00:00:00

  • Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

    abstract：BACKGROUND/AIMS:Based on the observation of biphasic induction of SGK1 expression in the regenerating liver, we investigated the role of SGK1 in the regulation of MEK/ERK signaling pathway which plays a crucial role in regulating growth and survival signaling. METHODS:To determine the role of SGK1 in the activation of...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.02.027

    authors： Won M,Park KA,Byun HS,Kim YR,Choi BL,Hong JH,Park J,Seok JH,Lee YH,Cho CH,Song IS,Kim YK,Shen HM,Hur GM

    更新日期：2009-07-01 00:00:00

  • A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

    abstract：:The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90069-n

    authors： Cammà C,Garofalo G,Almasio P,Tinè F,Craxì A,Palazzo U,Pinzello G,Fiorello F,Angelo PM,Pagliaro L

    更新日期：1991-11-01 00:00:00

  • Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons.

    abstract：BACKGROUND/AIMS:Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis. METHODS:We used a baboon model that mimics human alcoholic liver disease. Cytokeratin 7 and 19 expre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00144-2

    authors： Ren C,Paronetto F,Mak KM,Leo MA,Lieber CS

    更新日期：2003-06-01 00:00:00

  • S-adenosylmethionine protects post-ischemic mitochondrial injury in rat liver.

    abstract：BACKGROUND/AIMS:S-adenosylmethionine (SAM) is a thiol-containing compound with known therapeutic affects on cholestasis and hepatotoxicity. The aim of this study was to investigate the effect of SAM on the prevention of mitochondrial injury induced by hepatic ischemia and reperfusion. METHODS/RESULTS:Rats were subject...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00045-3

    authors： Jeon BR,Lee SM

    更新日期：2001-03-01 00:00:00

  • Management of hepatitis C: current and future perspectives.

    abstract：:Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In March 1997, the National Institutes of Health sponsored a Consensus Development Conference entitled "Management of Hepatitis C". The final statement from the Consensus Panel set forth clear, evidence-based gui...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80414-0

    authors： Hoofnagle JH

    更新日期：1999-01-01 00:00:00

  • Long-term outcome of asymptomatic liver hydatidosis.

    abstract：BACKGROUND/AIMS:The aim of this study was to determine the outcome of asymptomatic liver hydatid cysts in a cohort of 33 out of 59 carriers by evaluating clinical and ultrasonographic (US) changes 10-12 years after initial diagnosis. METHODS:We compared US features and cyst size with the original descriptions from 198...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80066-x

    authors： Frider B,Larrieu E,Odriozola M

    更新日期：1999-02-01 00:00:00

  • Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim of this study was to generate a human antibody fragment to hepatic stellate cells. METHODS:Phage display was used to genera...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.01.028

    authors： Elrick LJ,Leel V,Blaylock MG,Duncan L,Drever MR,Strachan G,Charlton KA,Koruth M,Porter AJ,Wright MC

    更新日期：2005-06-01 00:00:00

  • Prevalence of hepatitis B or C virus infection in patients with fulminant viral hepatitis. An analysis using polymerase chain reaction.

    abstract：BACKGROUND/METHODS:The cause of fulminant hepatitis is still not fully understood. We studied 23 patients with fulminant hepatitis, using polymerase chain reaction to detect hepatitis virus genomes. Tests for HBsAg and IgM anti-HAV and IgM anti-HBc were performed in all patients. Serum samples were stored at -70 degree...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80002-x

    authors： Inokuchi K,Nakata K,Hamasaki K,Daikoku M,Nakao K,Kato Y,Yatsuhashi H,Koga M,Yano M,Nagataki S

    更新日期：1996-03-01 00:00:00

  • Impairment of metabolic hepatic nerve action by chronic but not acute ethanol intoxication studied in isolated perfused rat liver.

    abstract：BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80025-6

    authors： Kucera T,Stümpel F,Jungermann K

    更新日期：1997-01-01 00:00:00

  • Long-term follow-up of chronic hepatitis C in patients diagnosed at a tertiary-care center.

    abstract：BACKGROUND/AIMS:The natural history of chronic hepatitis C (HCV) is not completely understood. This study was aimed to evaluate the long-term outcome of the disease over a prolonged period of time and to identify factors associated with progression. METHODS:One hundred and sixteen patients with non-cirrhotic chronic n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00088-5

    authors： Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

    更新日期：2001-08-01 00:00:00

  • Is resectable hepatocellular carcinoma a contraindication to liver transplantation? A novel decision model based on "number of patients needed to transplant" as measure of transplant benefit.

    abstract：BACKGROUND & AIMS:Number-needed-to-treat is used in assessing the effectiveness of a health-care intervention, and reports the number of patients who need to be treated to prevent one additional bad outcome. Although largely used in medical literature, there are no studies measuring the benefit of liver transplantation...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.01.022

    authors： Vitale A,Cucchetti A,Qiao GL,Cescon M,Li J,Ramirez Morales R,Frigo AC,Xia Y,Tuci F,Shen F,Cillo U,Pinna AD

    更新日期：2014-06-01 00:00:00

  • Expression of liver functions following sub-lethal and non-lethal doses of allyl alcohol and acetaminophen in the rat.

    abstract：BACKGROUND/AIMS:To relate severity of intoxication with allyl alcohol and acetaminophen to modulated hepatic gene expression of liver functions and regeneration. METHODS:Rats fasted for 12 h received acetaminophen 3.5 or 5.6 g per kg body weight, or allyl alcohol 100 or 125 microl by gastric tube, doses producing no a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80296-6

    authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

    更新日期：1997-07-01 00:00:00

  • Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient.

    abstract：:An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80252-1

    authors： Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

    更新日期：1993-06-01 00:00:00

  • Birth cohort-specific disparities in hepatocellular carcinoma stage at diagnosis, treatment, and long-term survival.

    abstract：BACKGROUND & AIMS:Individuals born between 1945 and 1965 account for nearly 75% of hepatitis C virus (HCV) infections in the United States. As this cohort ages, progressive HCV-related liver disease leading to cirrhosis and hepatocellular carcinoma (HCC) will place a significant burden on the healthcare system. We aim ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.09.006

    authors： Yan M,Ha J,Aguilar M,Bhuket T,Liu B,Gish RG,Cheung R,Wong RJ

    更新日期：2016-02-01 00:00:00