Epidemiology and surveillance for hepatocellular carcinoma: New trends.

Abstract:

:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a disease predominated by viral hepatitis - an increasing proportion of cases are now attributable to non-alcoholic steatohepatitis. Surveillance using ultrasound, with or without alpha-fetoprotein, every 6 months has been associated with improved early detection and improved overall survival; however, limitations in implementation lead to a high proportion of HCC being detected at late stages in clinical practice. Herein, we review the current state of HCC surveillance and highlight areas for future research, including improved risk stratification of at-risk patients, surveillance tools with higher sensitivity and specificity for early HCC, and interventions to increase surveillance utilisation.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Singal AG,Lampertico P,Nahon P

doi

10.1016/j.jhep.2019.08.025

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

250-261

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(19)30519-7

journal_volume

72

pub_type

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