Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers.

Abstract:

OBJECTIVE:Ibuprofen is a commonly used non-steroidal anti-inflammatory drug administered to treat injuries, joint pain, and recurrent muscular skeletal pain. The aim of this study was to determine the cutaneous irritancy of a medicated ibuprofen plaster compared with a placebo plaster in healthy volunteers. METHODS:Healthy volunteers (N = 31) were treated at the same time with one ibuprofen and one placebo plaster. The ibuprofen and placebo plaster were applied in a randomized fashion to sites on the left or right side of subjects' lower backs. At each scheduled visit, the plasters and applications sites were assessed for degree of adhesion and skin irritancy, respectively. The plasters were applied on study Days 1, 2, 3, 5, 8, 10, 12, 15, 17, and 19, with final plaster removal on Day 22. RESULTS:The ibuprofen medicated plaster compared with placebo had a lower percentage of Grade 1 (23.3% vs. 46.7%, respectively), Grade 2 (10% vs. 20%), and ≥Grade 3 (3% vs. 16.1%) irritancy scores after 21 days of application. The mean irritation score across the study was 0.40 for the ibuprofen medicated plaster and 1.18 for the placebo plaster. The irritation score on Day 22 of the study was 0.53 for the ibuprofen medicated plaster and 1.50 for placebo. The placebo plaster was associated with a higher number of stopped applications due to Grade 3 or above skin reactions compared with the ibuprofen medicated plaster (5 vs. 1, respectively). CONCLUSION:The ibuprofen medicated plaster was well tolerated and was associated with lower irritancy than the placebo plaster.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Maganji M,Connolly MP,Bhatt A

doi

10.1080/00325481.2018.1398047

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

19-23

issue

1

eissn

0032-5481

issn

1941-9260

journal_volume

130

pub_type

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