Role of primary care physicians in intrathecal pain management: a narrative review of the literature.

Abstract:

OBJECTIVES:The majority of patients seeking medical care for chronic pain consult a primary care physician (PCP). Because systemic opioids are commonly prescribed to patients with chronic pain, PCPs are attempting to balance the competing priorities of providing adequate pain relief while reducing risks for opioid misuse and overdose. It is important for PCPs to be aware of pain management strategies other than systemic opioid dose escalation when patients with chronic pain fail to respond to conservative therapies and to initiate a multimodal treatment plan. METHODS:The Medline database and evidence-based treatment guidelines were searched to identify publications on intrathecal (IT) therapy for the management of chronic pain. Selection of publications relevant to PCPs was based on the authors' clinical and research expertise. RESULTS:IT administration delivers analgesic medication directly into the cerebrospinal fluid, avoiding first-pass effect and bypassing the blood-brain barrier, thereby requiring lower medication doses. Morphine, a µ-opioid receptor agonist, and ziconotide, a non-opioid, selective N-type calcium channel blocker, are the only analgesics approved by the US Food and Drug Administration to treat chronic refractory pain by the IT route. Patients who are potential candidates for IT therapy may benefit from evaluation by an interventional pain physician. PCPs can play an important role in patient selection and referral for IT therapy and provide ongoing collaborative care for patients receiving IT therapy, including monitoring for efficacy and adverse events and facilitating communication with the treating specialist. CONCLUSIONS:Collaboration between PCPs and pain specialists may improve outcomes of and patient satisfaction with IT therapy and other interventional treatments.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

McDowell GC 2nd,Winchell J

doi

10.1080/00325481.2018.1448207

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

411-419

issue

4

eissn

0032-5481

issn

1941-9260

journal_volume

130

pub_type

杂志文章,评审
  • 'Essential' hypertension with hypokalemia. Caused by aldosterone-secreting adrenal adenoma.

    abstract::Primary aldosteronism is a potentially curable cause of hypertension; it occurs in about 1% of hypertensive patients. In the case reported here, persistent hypokalemia developed in a 72-year-old man who had been treated for 13 years for essential hypertension. Investigation revealed elevated aldosterone level and redu...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:

    authors: Burke M,Papo J,Stavorovsky M,Almog C

    更新日期:1984-08-01 00:00:00

  • Chemotherapy for lung cancer.

    abstract::Oat cell carcinoma is the one variety of primary lung cancer which is sufficiently responsive to a variety of drugs and drug combinations that a very high rate of response and significant prolongation of survival can be consistently achieved. The question of whether anyone has been "cured" by drug treatment awaits mor...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1978.11714758

    authors: Golbey RB

    更新日期:1978-02-01 00:00:00

  • Gastric volvulus. More common than previously thought?

    abstract::Gastric volvulus is torsion of the stomach, which can compromise the gastric orifices and result in either acute or chronic and intermittent symptoms. We believe that gastric volvulus, especially when partial or intermittent, may be more common than has been previously thought. The condition should be suspected in any...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699576

    authors: Llaneza PP,Salt WB 2nd

    更新日期:1986-10-01 00:00:00

  • Acute urinary retention: causes and treatment.

    abstract::Acute urinary retention often is secondary to obstruction of the bladder or distal genitourinary system, which may be induced by any of a number of medical or surgical conditions. Treatment varies according to the cause. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11715998

    authors: Ochsner MG

    更新日期:1982-02-01 00:00:00

  • Managing community-acquired pneumonia. Factors to consider in outpatient care.

    abstract::Most patients with community-acquired pneumonia are treated as outpatients, and choice of therapy is usually empirical because the etiologic agent is unknown. Therapy should include coverage for both typical and atypical organisms. In geographic areas with highly resistant S pneumoniae, one of the newer fluoroquinolon...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1999.04.668

    authors: Farber MO

    更新日期:1999-04-01 00:00:00

  • Early detection and management of COPD. What you can do to reduce the impact of this disabling disease.

    abstract::Primary care physicians play a pivotal role in the early identification of patients with COPD. Early diagnosis, along with aggressive intervention, is the only way that the increasing morbidity and mortality of COPD can be reversed. Any patient with a history of smoking should undergo evaluation for the possibility of...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2002.06.1225

    authors: Doherty DE

    更新日期:2002-06-01 00:00:00

  • Recent advances in management of gastroesophageal reflux.

    abstract::Gastroesophageal reflux is not synonymous with sliding hiatus hernia. It should be approached as a condition dependent on the intrinsic strength of the lower esophageal sphincter rather than on the presence of a hiatus hernia. The patient's account of symptoms is probably the most important means of diagnosis, but in ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1975.11713946

    authors: Cohen S

    更新日期:1975-01-01 00:00:00

  • Functional assessment in older patients.

    abstract::Preview Practical assessment of the functional and support factors affecting quality of life in older patients should be an integral part of medical management. This approach allows physicians to focus on remediable problems that compromise patients' daily functioning and may hinder them from living independently. In ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1996.11946120

    authors: Paist SS 3rd,Jafri A

    更新日期:1996-05-01 00:00:00

  • End-of-life care in advanced dementia.

    abstract::In the next 30 years, the average age of the population will continue to increase, as will the prevalence of dementia. The management of advanced dementia requires the careful orchestration of communication, prognostication, patient care, and caregiver education. Understanding the specific tools available to establish...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2014.10.2826

    authors: Heron CR,Simmons BB

    更新日期:2014-10-01 00:00:00

  • Evaluation of the bleeding patient.

    abstract::The evaluation of the bleeding patient starts with the integration of data from the history and physical examination. From this results either one probable explanation that can easily be substatniated by laboratory studies or, as more commonly occurs in practice, several possibilities that are reasonable and must be i...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11712257

    authors: Marengo-Rowe AJ,Leveson JE

    更新日期:1977-07-01 00:00:00

  • Pulmonary embolism. Guide to diagnosis, treatment, and prevention.

    abstract::While more remains to be learned about the natural history of deep vein thrombosis and pulmonary embolism, better information is now available on which to base decisions about diagnosis and treatment. Several retrospective and prospective studies have placed the value of lung scanning, venography, and pulmonary angiog...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699336

    authors: Broaddus C,Matthay MA

    更新日期:1986-03-01 00:00:00

  • Helicobacter pylori and peptic ulcer disease. Bridging the gap between knowledge and treatment.

    abstract::Eradication of H pylori and cure of peptic ulcer disease are possible if effective regimens are used correctly. Treatment markedly improves clinical outcomes and significantly decreases cost of care. As primary care physicians take a larger role in management of these infections, they need to understand the importance...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.03.423

    authors: Laine L,Fendrick AM

    更新日期:1998-03-01 00:00:00

  • Tailoring therapy to a stroke patient's potential.

    abstract::Stroke survivors can be plagued by numerous medical complications, including aspiration pneumonia, heart disease, depression, and venous thromboembolism. Given the impairment already caused by stroke itself, these patients require careful management by a comprehensive rehabilitation team. Dr Harvey discusses common st...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.08.552

    authors: Harvey RL

    更新日期:1998-08-01 00:00:00

  • Sexual aspects of headache. How sexual function relates to headaches and their causes and treatment.

    abstract::Since the sexual revolution of the 1960s, medical complications of sexual activity and sexual side effects related to use of medications have become a significant part of healthcare practice. Specifically, there has been an expanding interest in the treatment of headaches and their relationship to sexual function. Mos...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2001.01.824

    authors: Goldstein J

    更新日期:2001-01-01 00:00:00

  • Gastrointestinal foreign bodies. When to remove them, when to watch and wait.

    abstract::By being aware of which patients are at high risk for ingestion or insertion of foreign bodies, physicians can be on the lookout for objects in the gastrointestinal tract and ready to institute initial care. Esophageal foreign bodies and other objects that increase the chance of perforation or obstruction may require ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1992.11701481

    authors: Clarkston WK

    更新日期:1992-10-01 00:00:00

  • Essential echocardiographic evaluation in patients with suspected pulmonary hypertension: an overview for the practicing physician.

    abstract::Prompt and accurate diagnosis of patients presenting with symptoms suggestive of pulmonary arterial hypertension (PAH) is of outmost importance as delays in identifying this clinical entity have detrimental effects on both morbidity and mortality. Initial noninvasive assessment of these patients has traditionally incl...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2016.1115715

    authors: Vargas PE,Lopez-Candales A

    更新日期:2016-01-01 00:00:00

  • Management of portal hypertension.

    abstract::Primary prophylaxis is advisable for all patients with moderate-sized or large esophageal varices. After the first episode of bleeding, secondary prophylaxis should be initiated to prevent rebleeding. Multiple treatment modalities are available for each circumstance. Optimal regimens have not yet been established but ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.2006.11446045

    authors: Shah VH,Kamath P

    更新日期:2006-09-01 00:00:00

  • Occlusive peripheral arterial disease. Guidelines for office management.

    abstract::Occlusive peripheral arterial disease is rather easy to diagnose because of its characteristic symptoms and the ease with which the extremities and their circulation can be examined. Elevation and dependency tests give a rough but reliable estimate of the degree of ischemia, and if more objective data are desired, the...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11715993

    authors: Spittell JA Jr

    更新日期:1982-02-01 00:00:00

  • The effects of a commercially available weight loss program among obese patients with type 2 diabetes: a randomized study.

    abstract::The purpose of this study was to assess the effects of a commercially available weight loss program on weight and glycemic control among obese patients with type 2 diabetes. Participants included 69 patients (49 females, 20 males) with type 2 diabetes who had a mean +/- SD age of 52.2 +/- 9.5 years, a body mass index ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2009.09.2046

    authors: Foster GD,Borradaile KE,Vander Veur SS,Leh Shantz K,Dilks RJ,Goldbacher EM,Oliver TL,Lagrotte CA,Homko C,Satz W

    更新日期:2009-09-01 00:00:00

  • Bleeding esophagogastric varices. Ways to treat active episodes and prevent recurrence.

    abstract::Bleeding from esophagogastric varices carries a high mortality rate. Active variceal bleeding can usually be temporarily controlled medically with a combination of intravenous vasopressin and nitroglycerin, with balloon tamponade, or with endoscopic sclerotherapy. Because of the high likelihood of recurrence, long-ter...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1991.11700924

    authors: Marshall JB

    更新日期:1991-05-01 00:00:00

  • Investigation of microcytic anemia.

    abstract::This article on microcytic anemia is the first of several on laboratory investigation of anemia. Microcytic anemia, characterized by a mean corpuscular volume of less than 80 cu mu, is usually due to iron deficiency or chronic disease but may signify thalassemia minor. Exact identification of the cause is important, s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715037

    authors: Ward PC

    更新日期:1979-01-01 00:00:00

  • Nonmastectomy treatment of breast cancer. Current status of excision plus radiation.

    abstract::Treatment of primary breast cancer with excision of the tumor plus radiation is now an accepted alternative to mastectomy in women who desire breast preservation and have a suitable clinical presentation. Tumor size and location should be carefully considered before applying treatment with this method, the primary con...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1986.11699425

    authors: Lichter AS

    更新日期:1986-06-01 00:00:00

  • Effect of early weight loss on type 2 diabetes mellitus after 2 years of gastric banding.

    abstract:OBJECTIVE:Laparoscopic adjustable gastric banding (LAGB) is an established bariatric surgical procedure that produces meaningful weight loss and improvements in patients with type 2 diabetes mellitus (T2DM) and a body mass index (BMI) ≥ 30 kg/m2. This study examined the effect of LAGB on T2DM status in severely obese p...

    journal_title:Postgraduate medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3810/pgm.2012.11.2590

    authors: Edelman S,Bhoyrul S,Billy H,Cornell C,Okerson T

    更新日期:2012-11-01 00:00:00

  • Physical frailty and cognitive impairment is associated with diabetes and adversely impact functional status and mortality.

    abstract:OBJECTIVES:We investigated whether there was a higher prevalence of cognitive impairment (CI) and/or physical frailty (PF) in persons with diabetes compared to their non-diabetic counterparts, and the individual and combined impact of CI and PF on functional and mortality outcomes among diabetic older persons. METHOD:...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2018.1491779

    authors: Thein FS,Li Y,Nyunt MSZ,Gao Q,Wee SL,Ng TP

    更新日期:2018-08-01 00:00:00

  • Evaluating peripheral arterial occlusive disease.

    abstract::The clinical history and physical examination remain the most important factors in determining the presence, anatomic location, and physiologic extent of arterial occlusive disease and the need for operation. The physician should refrain from ordering arteriography to confirm the diagnosis of arterial disease unless o...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1976.11714271

    authors: Barnes RW

    更新日期:1976-02-01 00:00:00

  • Raising the curtain on cancer. Is the puzzle finally becoming clear?

    abstract::Looking back at the long history of cancer, we can still relate to that POSTGRADUATE MEDICINE editorial written 50 years ago: "None of the basic problems of cancer has been solved. The death rate is constantly mounting. Small wonder that many doctors face cancer with a pessimism bordering on resignation." The temptati...

    journal_title:Postgraduate medicine

    pub_type: 历史文章,杂志文章

    doi:10.3810/pgm.1997.09.307

    authors: Harpham WS,Hoel D

    更新日期:1997-09-01 00:00:00

  • Cost-effective laboratory testing.

    abstract::The increased utilization of diagnostic procedures has prompted interest in cost-effective laboratory testing. Clinically useful tests-useful in the sense that the patient benefits-are cost effective. The choice of test(s) is determined by the risks and benefits of proposed management. In practice, the first step in c...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1981.11715687

    authors: Burke MD

    更新日期:1981-02-01 00:00:00

  • Antiretroviral therapy for HIV infection. Heartening successes mixed with continuing challenges.

    abstract::Probably nothing in the field of medicine has changed as rapidly over the last decade as antiretroviral (ARV) therapy for HIV infection. New insights into pathogenesis, new tests for measuring virus levels in plasma, and availability of powerful new drugs have combined to transform the care of persons with HIV infecti...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1997.10.331

    authors: Henry K,Stiffman M,Feldman J

    更新日期:1997-10-01 00:00:00

  • Arthritis and the gut.

    abstract::The term "enteropathic arthritis" describes joint manifestations that occur in conjunction with gastrointestinal disease. Underlying causes include inflammatory bowel disease, reactive arthritis, iatrogenic disease. Whipple's disease, and other gastrointestinal diseases. A possible association between Reiter's syndrom...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1989.11704368

    authors: Finch W

    更新日期:1989-08-01 00:00:00

  • Resource use and costs in high-risk symptomatic peripheral artery disease patients with diabetes and prior acute coronary syndrome: a retrospective analysis.

    abstract:OBJECTIVES:As the prevalence of peripheral artery disease (PAD) increases there is growing concern about the associated healthcare burden. This burden has not been well-characterized in high-risk patients with concurrent diabetes and/or acute coronary syndrome (ACS). The objective of this analysis was to assess comorbi...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2016.1144447

    authors: Reed Chase M,Friedman HS,Navaratnam P,Heithoff K,Simpson RJ Jr

    更新日期:2016-01-01 00:00:00