Advances in the diagnostic options for prostate cancer.

Abstract:

:Over the past decade, despite the controversies surrounding prostate cancer screening, significant refinements have improved its application. PSA screening, although it has been questioned, appears to confer a mortality benefit and remains the most effective way to identify the possible presence of prostate cancer. Methods to improve the specificity of PSA screening and limit overdiagnosis of indolent cancers, including risk-stratified screening regimens, are currently being utilized. Certain imaging modalities, such as multiparametric MRI, have proven to be excellent adjuncts providing improved risk stratification and the ability for targeted biopsies; however, concerns over variability in interpretation and generalizability persist. A number of novel biomarkers have become available with nearly all demonstrating the ability to improve upon the specificity of PSA screening; however, optimal timing, direct comparisons, and usefulness in conjunction with imaging modalities remain to be elucidated. With the improvement in testing options and recognition of the risk/benefit ratio for men undergoing screening for prostate cancer, the increasing role of shared decision making in the process is emphasized.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

French WW,Wallen EM

doi

10.1080/00325481.2020.1822067

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

52-62

issue

sup4

eissn

0032-5481

issn

1941-9260

journal_volume

132

pub_type

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