Osteoblast as a target of anti-osteoporotic treatment.

Abstract:

:Osteoblasts are mesenchymal cells that play a key role in maintaining bone homeostasis; they are responsible for the production of extracellular matrix proteins, regulation of matrix mineralization, control of bone remodeling and regulate osteoclast differentiation. Osteoblasts have an essential role in the pathogenesis of many bone diseases, particularly osteoporosis. For many decades, the main current available treatments for osteoporosis have been represented by anti-resorptive drugs, such as bisphosphonates, which act mainly by inhibiting osteoclasts maturation, proliferation and activity; nevertheless, in recent years much attention has been paid on anabolic aspects of osteoporosis treatment. Many experimental evidences support the hypothesis of direct effects of the classical anti-resorptive drugs also on osteoblasts, and recent progress in understanding bone physiology have led to the development of new pharmacological agents such as anti-sclerostin antibodies and teriparatide which directly target osteoblasts, inducing anabolic effects and promoting bone formation.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Corrado A,Sanpaolo ER,Di Bello S,Cantatore FP

doi

10.1080/00325481.2017.1362312

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

858-865

issue

8

eissn

0032-5481

issn

1941-9260

journal_volume

129

pub_type

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